Expression of intercellular adhesion molecule-1 in hepatocellular carcinoma.

Abstract:

:The expression of intercellular adhesion molecule-1 (ICAM-1) was investigated in frozen sections obtained from 40 resected liver specimens of patients with hepatocellular carcinoma using immunoperoxidase techniques and immunoelectron microscopy. ICAM-1 was expressed in 80% of the HCC specimens on the membrane of cancer cells. In noncancerous regions characterized by cirrhosis in 28 cases and chronic hepatitis in 12 cases, ICAM-1 was rarely expressed on hepatocytes but was expressed mainly on the endothelium of portal vessels and sinusoidal lining cells. These results suggest that expression of ICAM-1 in hepatocellular carcinoma may be induced by malignant transformation of hepatocytes.

journal_name

J Surg Oncol

authors

Torii A,Harada A,Nakao A,Nonami T,Ito M,Takagi H

doi

10.1002/jso.2930530410

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

239-42

issue

4

eissn

0022-4790

issn

1096-9098

journal_volume

53

pub_type

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