Abstract:
:Fresh homogenized mammary gland adenocarcinoma (C3HBA) material was subcutaneously inoculated in the anterior right thigh of transplant host mice (C3H/HeJ). When tumors were palpable, the mice were separated into three groups. The test group received biweekly intratumoral injections of Mycobacterium ulcerans filtrate containing 40 mg of protein per ml. One control group received intratumoral injections of normal physiological saline, and the remaining group received no treatment at all. The survival rate of toxin-treated animals was 13.5% at 15 weeks when compared with the control groups. Additionally, tumor metastasis was apparently abrogated in test animals when compared to the control animals. Marked necrosis of the tumors in the test animals was noted by histological examination. Controls showed slight to moderate degrees of tumor necrosis. In this model Mycobacterium ulcerans toxin appears to have therapeutic value as an antitumor agent.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Heggers JP,Robson MC,Yetter JF,Kreig RE Jr,Jennings PBdoi
10.1002/jso.2930110210subject
Has Abstractpub_date
1979-01-01 00:00:00pages
161-9issue
2eissn
0022-4790issn
1096-9098journal_volume
11pub_type
杂志文章abstract::The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260213
更新日期:1984-06-01 00:00:00
abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570207
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To compare 3-year clinical outcomes of radiofrequency ablation (RFA) targeting 5- or 10-mm margins for small hepatocellular carcinomas (HCCs) in cirrhotic patients. METHODS:In total, 96 cirrhotic patients with a small solitary HCC (diameter ≤3 cm) were included in this prospective trial (ChiC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.24607
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070508
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. METHODS:We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199806)68:2<107::aid-jso7>
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Proper tip position is a major determinant of totally implantable venous access device (TIVAD) outcome. The aim of this study is to analyze the potential utilization of intravenous electrocardiography (IV-ECG) to help inexperienced operators for TIVAD placement. PATIENTS AND METHODS:This is a retrospective,...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.23000
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23549
更新日期:2014-06-01 00:00:00
abstract::Malignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and ca...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240320
更新日期:1983-11-01 00:00:00
abstract::Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. T...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330206
更新日期:1986-10-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21722
更新日期:2010-12-01 00:00:00
abstract::Forty-four consecutive cases of "early gastric cancer" were studied according to the macroscopic classification proposed by the Japanese Gastroenterological and Endoscopy Society and further analyzed in terms of growth patterns. The tumours were then classified into the small mucosal type, the superficially spreading ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510211
更新日期:1992-10-01 00:00:00
abstract::Tumor infiltrating lymphocytes (TILs) are capable of mediating significant tumor regressions in vitro and in vivo in animal systems. In humans, however, many TIL cell lines are not cytotoxic in vitro, and clinical trials thus far have been less than encouraging. We attempted to correlate TIL cytotoxicity with time of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430104
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:We sometimes encounter hepatocellular carcinoma (HCC) with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia (FNH) in macroscopic appearance. The fibrolamellar variant sometimes shows this appearance; however, this type of HCC can be clearly differentiated from fibrolamellar va...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20615
更新日期:2006-12-01 00:00:00
abstract::Gallbladder adenocarcinoma (GBA) postresection 5-year survival rates are less than 5%, but when histologically confined to the mucosa or submucosa, survival rates of 64% (5 years) and 44% (10 years) have been reported. Whether any other histologic features of GBA have prognostic significance is unknown. This investiga...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930340105
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25785
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). METHODS:Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25486
更新日期:2019-08-01 00:00:00
abstract::This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230105
更新日期:1983-05-01 00:00:00
abstract::In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma-associated antigen (TAA) and complet...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930460104
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:To document radical cystectomy (RC) outcomes in patients over 80 years old across Quebec during the years 2000-2009 and to examine potentially related factors. METHODS:Within Quebec health insurance medical services database, we identified patients over 80 years who underwent RC. The outcomes analyzed were ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23887
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21425
更新日期:2010-01-01 00:00:00
abstract::Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-...
journal_title:Journal of surgical oncology
pub_type: 历史文章,杂志文章,评审
doi:10.1002/jso.24888
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22001
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23590
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Adipokines may explain the newly established association of obesity with hepatocellular carcinoma (HCC). This study investigated if adiponectin levels in HCC patients differed from healthy controls and their potential effect in the development of HCC. METHODS:Radioimmunoassay was used to dete...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23059
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24692
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Open extended cholecystectomy (O-EC) has long been the recommended treatment for resectable gallbladder cancer (GBC), while the minimally-invasive approach for EC (MIS-EC) remains controversial. Our aim was to analyze overall survival of GBC patients treated with MIS-EC vs O-EC at the national level. METHOD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26062
更新日期:2020-06-12 00:00:00
abstract::Twenty-nine patients with advanced refractory breast cancer were treated with cisplatin 20 mg/m2/d and VP-16 100 mg/d for 5 days every 3-4 weeks. Ten patients received mitomycin C 10 mg/m2 every 6 weeks additionally. Partial response was obtained in 10 of 26 evaluable patients (38%). The response rates for the group t...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.2930500411
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24318
更新日期:2016-09-01 00:00:00