Tumoricidal effects of Mycobacterium ulcerans toxin on murine adenocarcinoma (C3HBA).

Abstract:

:Fresh homogenized mammary gland adenocarcinoma (C3HBA) material was subcutaneously inoculated in the anterior right thigh of transplant host mice (C3H/HeJ). When tumors were palpable, the mice were separated into three groups. The test group received biweekly intratumoral injections of Mycobacterium ulcerans filtrate containing 40 mg of protein per ml. One control group received intratumoral injections of normal physiological saline, and the remaining group received no treatment at all. The survival rate of toxin-treated animals was 13.5% at 15 weeks when compared with the control groups. Additionally, tumor metastasis was apparently abrogated in test animals when compared to the control animals. Marked necrosis of the tumors in the test animals was noted by histological examination. Controls showed slight to moderate degrees of tumor necrosis. In this model Mycobacterium ulcerans toxin appears to have therapeutic value as an antitumor agent.

journal_name

J Surg Oncol

authors

Heggers JP,Robson MC,Yetter JF,Kreig RE Jr,Jennings PB

doi

10.1002/jso.2930110210

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

161-9

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

11

pub_type

杂志文章
  • The role and value of surgery in metastatic renal adenocarcinoma: a retrospective clinical study of 106 nephrectomized cases.

    abstract::The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260213

    authors: Appelqvist P

    更新日期:1984-06-01 00:00:00

  • Expression of desmoglein I in squamous cell carcinoma of the esophagus.

    abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570207

    authors: Natsugoe S,Aikou T,Shimada M,Kumanohoso T,Tezuka Y,Sagara M,Yoshinaka H,Baba M,Fukumoto T

    更新日期:1994-10-01 00:00:00

  • Radiofrequency ablation using a 10-mm target margin for small hepatocellular carcinoma in patients with liver cirrhosis: A prospective randomized trial.

    abstract:BACKGROUND AND OBJECTIVES:To compare 3-year clinical outcomes of radiofrequency ablation (RFA) targeting 5- or 10-mm margins for small hepatocellular carcinomas (HCCs) in cirrhotic patients. METHODS:In total, 96 cirrhotic patients with a small solitary HCC (diameter ≤3 cm) were included in this prospective trial (ChiC...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jso.24607

    authors: Liao M,Zhong X,Zhang J,Liu Y,Zhu Z,Wu H,Zeng Y,Huang J

    更新日期:2017-06-01 00:00:00

  • Leveraging the increased rates of pathologic complete response after neoadjuvant treatment in breast cancer to de-escalate surgical treatments.

    abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26236

    authors: Esgueva A,Siso C,Espinosa-Bravo M,Sobrido C,Miranda I,Salazar JP,Rubio IT

    更新日期:2021-01-01 00:00:00

  • A computerized tumor-registry system for persons who do not love computers.

    abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070508

    authors: Johnson IC,Blumenson LE,Bross ID

    更新日期:1975-01-01 00:00:00

  • Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. METHODS:We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom an...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199806)68:2<107::aid-jso7>

    authors: Iskaros BF,Hu X,Sparano JA,Fineberg SA

    更新日期:1998-06-01 00:00:00

  • Intravenous electrocardiography helps inexperienced operators to place totally implantable venous access device more accurately.

    abstract:BACKGROUND:Proper tip position is a major determinant of totally implantable venous access device (TIVAD) outcome. The aim of this study is to analyze the potential utilization of intravenous electrocardiography (IV-ECG) to help inexperienced operators for TIVAD placement. PATIENTS AND METHODS:This is a retrospective,...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.23000

    authors: Wang YC,Huang CH,Lin FS,Lin WY,Fan SZ,Lin CP,Sun WZ

    更新日期:2012-06-15 00:00:00

  • The role of preoperative positron emission tomography/computed tomography (PET/CT) in patients with high-risk melanoma.

    abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23549

    authors: Barsky M,Cherkassky L,Vezeridis M,Miner TJ

    更新日期:2014-06-01 00:00:00

  • Carcinoembryogenic antigen and lysosomal enzymes in gastric juice as an aid in the diagnosis of gastric cancer.

    abstract::Malignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and ca...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930240320

    authors: Graffner H,Hultberg B

    更新日期:1983-11-01 00:00:00

  • Limitation of immunohistochemical localization of estrogen receptor.

    abstract::Although the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. T...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930330206

    authors: Chaudhuri PK,Chaudhuri B,Beattie CW,Bigham BZ,Das Gupta TK

    更新日期:1986-10-01 00:00:00

  • Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases.

    abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25588

    authors: Tang H,Moro A,Feng W,Lai Y,Xiao Z,Liu Y,Wang K

    更新日期:2019-09-01 00:00:00

  • Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis.

    abstract:BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21722

    authors: Arigami T,Uenosono Y,Hirata M,Hagihara T,Yanagita S,Ishigami S,Natsugoe S

    更新日期:2010-12-01 00:00:00

  • Early gastric cancer: an analysis of 44 cases with emphasis on the prognostic significance of the macroscopic and microscopic growth patterns.

    abstract::Forty-four consecutive cases of "early gastric cancer" were studied according to the macroscopic classification proposed by the Japanese Gastroenterological and Endoscopy Society and further analyzed in terms of growth patterns. The tumours were then classified into the small mucosal type, the superficially spreading ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930510211

    authors: Olivera P,Nobre-Leitão C,Chaves P

    更新日期:1992-10-01 00:00:00

  • MC-38 adenocarcinoma tumor infiltrating lymphocytes: correlation of cytotoxicity with time of tumor harvest after tumor inoculation.

    abstract::Tumor infiltrating lymphocytes (TILs) are capable of mediating significant tumor regressions in vitro and in vivo in animal systems. In humans, however, many TIL cell lines are not cytotoxic in vitro, and clinical trials thus far have been less than encouraging. We attempted to correlate TIL cytotoxicity with time of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930430104

    authors: Lafreniere R,Borkenhagen K,Bryant LD

    更新日期:1990-01-01 00:00:00

  • Hepatocellular carcinoma with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia in macroscopic appearance.

    abstract:BACKGROUND:We sometimes encounter hepatocellular carcinoma (HCC) with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia (FNH) in macroscopic appearance. The fibrolamellar variant sometimes shows this appearance; however, this type of HCC can be clearly differentiated from fibrolamellar va...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20615

    authors: Yamamoto M,Ariizumi S,Yoshitoshi K,Saito A,Nakano M,Takasaki K

    更新日期:2006-12-01 00:00:00

  • Gallbladder adenocarcinoma: the prognostic significance of histologic grade.

    abstract::Gallbladder adenocarcinoma (GBA) postresection 5-year survival rates are less than 5%, but when histologically confined to the mucosa or submucosa, survival rates of 64% (5 years) and 44% (10 years) have been reported. Whether any other histologic features of GBA have prognostic significance is unknown. This investiga...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930340105

    authors: Johnson LA,Lavin PT,Dayal YY,Geller SA,Doos WG,Cooper HS,Gerber JE,Masse SR,Weiland LH,Moertel CG

    更新日期:1987-01-01 00:00:00

  • Lymph node regression after neoadjuvant chemotherapy: A predictor of survival in gastric cancer.

    abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25785

    authors: Pereira MA,Ramos MFKP,Dias AR,Cardili L,Ribeiro RRE,Charruf AZ,de Castria TB,Zilberstein B,Ceconello I,Avancini Ferreira Alves V,Ribeiro U Jr,de Mello ES

    更新日期:2020-04-01 00:00:00

  • Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.

    abstract:BACKGROUND:The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). METHODS:Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international mul...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.25486

    authors: Tsilimigras DI,Hyer JM,Moris D,Sahara K,Bagante F,Guglielmi A,Aldrighetti L,Alexandrescu S,Marques HP,Shen F,Koerkamp BG,Endo I,Pawlik TM,other members of the International Intrahepatic Cholangiocarcinoma Study Group.

    更新日期:2019-08-01 00:00:00

  • Surgical treatment of carcinoma of the breast. I. Pathological finding and pattern of relapse.

    abstract::This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930230105

    authors: Lee YT,Terry R

    更新日期:1983-05-01 00:00:00

  • Adjuvant, specific, active immunotherapy for resectable squamous cell lung carcinoma: a 5-year survival analysis.

    abstract::In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma-associated antigen (TAA) and complet...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.2930460104

    authors: Takita H,Hollinshead AC,Adler RH,Bhayana J,Ramundo M,Moskowitz R,Rao UN,Raman S

    更新日期:1991-01-01 00:00:00

  • Radical cystectomy in patients over 80 years old in Quebec: A population-based study of outcomes.

    abstract:OBJECTIVES:To document radical cystectomy (RC) outcomes in patients over 80 years old across Quebec during the years 2000-2009 and to examine potentially related factors. METHODS:Within Quebec health insurance medical services database, we identified patients over 80 years who underwent RC. The outcomes analyzed were ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23887

    authors: Zakaria AS,Santos F,Tanguay S,Kassouf W,Aprikian AG

    更新日期:2015-06-01 00:00:00

  • Impact of lymph-node metastasis site in patients with thoracic esophageal cancer.

    abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21425

    authors: Kunisaki C,Makino H,Kimura J,Oshima T,Fujii S,Takagawa R,Kosaka T,Ono HA,Akiyama H

    更新日期:2010-01-01 00:00:00

  • Historical perspectives and future directions in the surgical management of retroperitoneal sarcoma.

    abstract::Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-...

    journal_title:Journal of surgical oncology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1002/jso.24888

    authors: Tseng WW,Seo HJ,Pollock RE,Gronchi A

    更新日期:2018-01-01 00:00:00

  • Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer.

    abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22001

    authors: Shao W,Wang W,Xiong XG,Cao C,Yan TD,Chen G,Chen H,Yin W,Liu J,Gu Y,Mo M,He J

    更新日期:2011-12-01 00:00:00

  • Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma.

    abstract:INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.23590

    authors: Coventry BJ,Kroon HM,Giles MH,Henderson M,Speakman D,Wall M,Barbour A,Serpell J,Paddle P,Coventry AG,Sullivan T,Smithers BM

    更新日期:2014-06-01 00:00:00

  • The promoting effect of adiponectin in hepatocellular carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Adipokines may explain the newly established association of obesity with hepatocellular carcinoma (HCC). This study investigated if adiponectin levels in HCC patients differed from healthy controls and their potential effect in the development of HCC. METHODS:Radioimmunoassay was used to dete...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23059

    authors: Chen MJ,Yeh YT,Lee KT,Tsai CJ,Lee HH,Wang SN

    更新日期:2012-08-01 00:00:00

  • Cost analysis of postmastectomy reconstruction: A comparison of two staged implant reconstruction using tissue expander and acellular dermal matrix with abdominal-based perforator free flaps.

    abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24692

    authors: Tran BNN,Fadayomi A,Lin SJ,Singhal D,Lee BT

    更新日期:2017-09-01 00:00:00

  • Long-term survival following minimally invasive extended cholecystectomy for gallbladder cancer: A 7-year experience from the National Cancer Database.

    abstract:BACKGROUND:Open extended cholecystectomy (O-EC) has long been the recommended treatment for resectable gallbladder cancer (GBC), while the minimally-invasive approach for EC (MIS-EC) remains controversial. Our aim was to analyze overall survival of GBC patients treated with MIS-EC vs O-EC at the national level. METHOD...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26062

    authors: AlMasri S,Nassour I,Tohme S,Adam MA,Hoehn RS,Bartlett DL,Lee KK,Zureikat AH,Paniccia A

    更新日期:2020-06-12 00:00:00

  • Cisplatin plus VP-16 combination chemotherapy in advanced refractory breast cancer.

    abstract::Twenty-nine patients with advanced refractory breast cancer were treated with cisplatin 20 mg/m2/d and VP-16 100 mg/d for 5 days every 3-4 weeks. Ten patients received mitomycin C 10 mg/m2 every 6 weeks additionally. Partial response was obtained in 10 of 26 evaluable patients (38%). The response rates for the group t...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.2930500411

    authors: Içli F,Günel N,Dinçol D,Karaoğuz H,Demirkazik A

    更新日期:1992-08-01 00:00:00

  • Ex vivo detection of tumoral lymph nodes of colorectal origin with fluorescence imaging after intraoperative intravenous injection of indocyanine green.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24318

    authors: Liberale G,Galdon MG,Moreau M,Vankerckhove S,El Nakadi I,Larsimont D,Donckier V,Bourgeois P

    更新日期:2016-09-01 00:00:00