Cisplatin plus VP-16 combination chemotherapy in advanced refractory breast cancer.

Abstract:

:Twenty-nine patients with advanced refractory breast cancer were treated with cisplatin 20 mg/m2/d and VP-16 100 mg/d for 5 days every 3-4 weeks. Ten patients received mitomycin C 10 mg/m2 every 6 weeks additionally. Partial response was obtained in 10 of 26 evaluable patients (38%). The response rates for the group treated with and without mitomycin C were 40% and 37.5%, respectively. Median response duration was 5.5 months in partial responders. Median survival was 9.5 months for partial responders and 2 months for the rest of the patients. Cisplatin and VP-16 combination can be considered as a salvage treatment in heavily pretreated patients with advanced breast cancer.

journal_name

J Surg Oncol

authors

Içli F,Günel N,Dinçol D,Karaoğuz H,Demirkazik A

doi

10.1002/jso.2930500411

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

251-3

issue

4

eissn

0022-4790

issn

1096-9098

journal_volume

50

pub_type

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