Abstract:
BACKGROUND:Surgical resection provides the only potentially curative treatment of pancreatic cancer. Neoadjuvant chemotherapy and/or radiation (NAT) is used to downstage patients with borderline resectable tumors. The objective of this study was to examine the postoperative morbidity and mortality of NAT after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDA). METHODS:Using the American College of Surgeons-National Surgical Quality Improvement Project Targeted Pancreatectomy data, we identified patients who underwent a PD for PDA from 2014 to 2015. Patients were grouped by receipt of NAT 90 days before PD. Bivariable and multivariable analyses was used to compare postoperative outcomes. RESULTS:A total of 3748 patients with PDA underwent PD; 926 (24.7%) received NAT. Those in the NAT group had more major vein resections, and longer operating times (all P < 0.001). On pathologic staging, those in the NAT group had smaller tumors (T1, 10.9% vs 5.1%; P < 0.001) and fewer nodes positive (N0, 49% vs 28%; P < 0.001). There were no differences in 30-day postoperative mortality or overall complications. On multivariable analysis, patients who received NAT had a lower likelihood of pancreatic fistula (OR, 0.67; P < 0.001). CONCLUSION:NAT does not increase the overall postoperative morbidity or mortality of PD for PDA. There is a decreased likelihood of pancreatic fistulas in patients that receive neoadjuvant therapy.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Cools KS,Sanoff HK,Kim HJ,Yeh JJ,Stitzenberg KBdoi
10.1002/jso.25183subject
Has Abstractpub_date
2018-09-01 00:00:00pages
455-462issue
3eissn
0022-4790issn
1096-9098journal_volume
118pub_type
杂志文章abstract:BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. A...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.23945
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The median survival for patients with stage IV metastatic melanoma is usually limited to approximately 1 year. In the case of liver metastasis, resection and ablation can achieve long-term survival. This study aimed to describe the outcomes after liver resection or ablation for metastatic melanoma to the liv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23929
更新日期:2015-06-01 00:00:00
abstract::Ten children with locally advanced or recurrent tumors were treated on a Phase I/II study to assess the feasibility and toxicity of intraoperative radiotherapy (IORT) for primary and recurrent pediatric solid malignancies at high risk for local recurrence. Eligible patients include all primary and recurrent pediatric ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1096-9098(199608)62:4<267::AID-JSO8>
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Prolonged air leaks (PAL) are the most frequent complication after lobectomy for non-small cell lung cancer, even in case of minimally invasive approaches. We developed a novel score to identify high-risk patients for PAL during minimally invasive lobectomy. METHODS:A dedicated database was c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25289
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 pati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25895
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Few studies have focused on distribution of lymph node metastasis. The aim of this study is to evaluate the prognostic significance of the location of involved lymph nodes in patients with advanced mid or low rectal cancer. METHODS:We defined proximal lymph node involvement (PLNp) as superior rectal and inf...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21966
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To investigate the significance of palliative gastrectomy for different types of metastatic gastric cancer patients displaying peritoneal dissemination, hepatic metastasis, distant lymph node metastasis occurring locally during late-stage disease, and multi-organ metastases. METHODS:We performed a retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23158
更新日期:2012-12-01 00:00:00
abstract::This is a review of a rare case of acute appendicitis secondary to metastatic nasopharyngeal carcinoma (NPC) that had never before been reported in the literature. The clinical presentation did not differ from usual cases of acute appendicitis, but the pathology caused us to re-evaluate the NPC stage of the patient. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600213
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23934
更新日期:2015-06-01 00:00:00
abstract::Intrapancreatic extension of pancreatic duct cell carcinoma in 19 resectable cases was evaluated by both hematoxylin and eosin (H&E) staining and quick immunostaining using antibodies against cancer-associated antigens--e.g., CA19-9, DUPAN 2, and CEA--on the intraoperative frozen-section biopsy during the course of la...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400105
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the fi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24708
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We performed a retrospective analysis to assess the influence of different prognostic factors, including the International Prognostic Index (IPI), that can predict the outcome in patients with primary large bowel lymphoma (Stage IE) treated with combined therapy (surgery followed by chemothera...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10103
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Leiomyosarcoma of the inferior vena cava (IVC) is a rare tumor which presents a unique surgical challenge. We present a series of six cases of leiomyosarcoma resection performed with IVC reconstruction. METHODS:Retrospective chart review was performed for patients undergoing initial operative resection of p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23798
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the efficacy of preoperative ultrasound (US) scanning in identifying lymph node metastasis before sentinel node biopsy (SNB), we conducted a prospective study on 125 patients with primary cutaneous melanoma (CM). METHODS:We prospectively enrolled 125 patients with >1 mm thick CM a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10248
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma. MATERIALS AND METHODS:From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21136
更新日期:2008-11-01 00:00:00
abstract::A patient with simultaneous metachronous carcinoma and polyps of the large bowel is presented. The importance of carcinoma as a predisposing cause to perforation during barium enema is stressed. In view of the considerable incidence of recurrent large bowel tumors, careful routine follow-up studies should be undertake...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080409
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Limb salvage is viable in the majority of patients with malignant bone tumors, but especially in case of extensive tumors and bad soft tissue conditions, it is challenging in upper extremity. OBJECTIVES/METHOD:The clinical and radiological results of 21 patients, who had free vascularized fibular grafts (VF...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20326
更新日期:2006-08-01 00:00:00
abstract::Advances in the surgical treatment of primary malignancies and the recent chemotherapy have led to an expansion of the surgical treatment of metastatic lung tumors. However, multiple pulmonary metastases are often found and may affect both lungs. It is difficult to reach tumors in the posterior parts of the lung when ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500210
更新日期:1992-06-01 00:00:00
abstract::A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion oc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310113
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has recently become an important non-invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biolo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21386
更新日期:2009-12-15 00:00:00
abstract::There are a number of retroperitoneal pathologies that may be confused with adrenal tumors. It is important to suspect and recognize these conditions as their management and work up might be different than adrenal tumors. This review will go in to the differential diagnosis and unique features of these conditions. A m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23133
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25234
更新日期:2018-11-01 00:00:00
abstract::This is a retrospective study of 462 patients who had masectomy and axillary dissection for carcinoma of the breast during 1971-1980. Actuarial analysis of relapse rates up to 5 years showed that the extent of involvement of axillary lymph nodes was the most important prognostic factor. Among patients without any axil...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270109
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the potential role of indocyanine green (ICG) fluorescence imaging after intraoperative intravenous (IV) injection for the "ex vivo" detection of metastatic lymph nodes (mLNs) of colorectal cancer origin. METHODS:Fresh-fixed LNs in cassettes and/or par...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24318
更新日期:2016-09-01 00:00:00
abstract::Malignant bowel obstruction (MBO) is a common problem for patients with advanced malignancy, especially colorectal and ovarian cancers. Symptoms include pain, bloating, nausea and vomiting, and inability to eat. Treatment options consist of a wide range of surgical and nonsurgical interventions (medications, endoscopi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25451
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Certain tumor-related factors like thickness increases the risk of nodal metastasis and may affect survival in patients with oral tongue cancers. The objective of this study is to identify those tumor-related prognostic predictors that can potentially influence decision for adjuvant radiothera...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23583
更新日期:2014-06-01 00:00:00
abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200105
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Preoperative prognostic information to select a treatment strategy is important especially in patients who need highly aggressive surgery, such as those with biliary cancer. We evaluated various prognostic factors and non-curative surgical factors using multidetector computed tomography (MDCT). METHODS:We r...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21501
更新日期:2010-04-01 00:00:00
abstract::Three patients with unresectable malignant retroperitoneal tumors that invaded and perforated the distal duodenum presented with sepsis unresponsive to antibiotics. A technique of proximal side-to-side duodenojejunostomy with stapled occlusion of the distal duodenum resulted in successful diversion and immediate resol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260410
更新日期:1984-08-01 00:00:00
abstract::A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradiol, and total estrogens. Eleven years after the onset of his disease he remains clinically well. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270203
更新日期:1984-10-01 00:00:00