Abstract:
:The effect of zinc deficiency on calmodulin function was investigated by assessing the in vivo activity of two calmodulin regulated enzymes, adenosine 3',5'-monophosphate (c-AMP) and guanosine 3',5'-monophosphate (c-GMP) phosphodiesterase (PDE) in several rat tissues. Enzymatic activities in brain, heart, and testis of rats fed a zinc deficient diet were compared with activities in these tissues from pair fed, zinc supplemented rats. In testis, a tissue in which zinc concentration decreased with zinc deficient diet, enzyme activities were significantly decreased over those in rats who were pair fed zinc supplemented diets. In brain and heart, tissues in which zinc concentrations did not change with either diet, enzymatic activities between the groups were not different. These results indicate that zinc deficiency influences the activity of calmodulin-regulated phosphodiesterases in vivo supporting the hypothesis that zinc plays a role in calmodulin function in vivo in zinc sensitive tissues.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Law JS,McBride SA,Graham S,Nelson NR,Slotnick BM,Henkin RIdoi
10.1007/BF02797137subject
Has Abstractpub_date
1988-08-01 00:00:00pages
221-6issue
3eissn
0163-4984issn
1559-0720journal_volume
16pub_type
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