Radiosensitizer AK-2123 as modulating agent in the chemotherapy of experimental metastases.

Abstract:

:Therapeutic effect of Cyclophosphamide (CPA) and radiosensitizer AK-2123 (AK) combination versus CPA alone in the same doses was investigated on transplanted LL carcinoma and B 16 melanoma. Antimetastatic efficacy of different doses of CPA and combined therapy was evaluated. Our data demonstrate that the effect of combined treatment by CPA at low uneffective doses (60 mg/kg, 40 mg/kg, 20 mg/kg at the 3rd and the 7th day after transplantation) and AK at low daily doses (1 mg/kg and 0.1 mg/kg for 3-9 days after transplantation) is equal or superior to the effect of CPA alone at the therapeutic dose (120 mg/kg).

journal_name

Neoplasma

journal_title

Neoplasma

authors

Konovalova NP,Diatchkovskaya RF,Volkova LM,Kagiya TV

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

119-22

issue

3

eissn

0028-2685

issn

1338-4317

journal_volume

42

pub_type

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