The effect of repeated dose of x-irradiation on the progress of HeLa cells through the cell cycle.

Abstract:

:In contradistinction to the increased fraction of HeLa S 3 cells in S phase after irradiation by a single dose in a range of 25--200 R, cultures irradiated by a second dose at time of morphologic restitution of mitotic activity exhibited decreased fraction of cells in S phase. The interpretation is that passage from G1 to S was reduced due to disturbances in subsystems which have not been fully repaired.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Siracká E

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

629-34

issue

6

eissn

0028-2685

issn

1338-4317

journal_volume

23

pub_type

杂志文章
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    abstract::The direct effect of selected cytostatic drugs on natural killer (NK) cell activity was evaluated. Peripheral blood mononuclear cells from healthy donors were tested for their cytolytic activity in vitro in the presence of adriamycin, methotrexate, leucovorin, vincristin, cytosine arabinoside and teniposide. Most of t...

    journal_title:Neoplasma

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    doi:

    authors: Ujházy P,Babusíková O

    更新日期:1991-01-01 00:00:00

  • Malignant tumors in Cuban children. Fourth triennial 1973-1975 of the national cancer registry.

    abstract::The incidence of malignant tumors in children is not as high as that in adults, though in Cuba and other countries they are the most frequent causes of death in this age group. Data of the fourth triennial of the Registro Nacional del Cáncer (Cuban Cancer Registry) in the period 1973-1975 are presented. In the age gro...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Alert J,Jimenez J

    更新日期:1980-01-01 00:00:00

  • Inducible high-affinity binding site for benzo(a)pyrene in cytosol from rat liver.

    abstract::By the use of the dextran-coated charcoal method the presence of a high-affinity binding site for benzo(a)pyrene in the cytosol from rat liver (R strain) has been demonstrated. This binder was saturable by ligand concentration and by time. Sucrose density gradient analysis after charcoal treatment revealed one major p...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mureşan Z,Stoica A,Stafidov N,Voiculetz N

    更新日期:1987-01-01 00:00:00

  • BioBran-augmented maturation of human monocyte-derived dendritic cells.

    abstract:UNLABELLED:BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; T...

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    pub_type: 杂志文章

    doi:10.4149/neo_2009_02_89

    authors: Cholujova D,Jakubikova J,Sedlak J

    更新日期:2009-01-01 00:00:00

  • Prediction of cancer incidence in Cracow and Bratislava.

    abstract::Projections for the incidence of all and selected major sites of cancer in the cities of Cracow and Bratislava were constructed for each year of the period 1978-1982 on the basis of data observed in the years 1968-1977. More or less increasing of unchanging trends were predicted for the malignant neoplasms of bladder,...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Pawłega J,Plesko I,Dimitrova E

    更新日期:1982-01-01 00:00:00

  • Iron-tumor cell interaction and regulation of Ca2+ homeostasis: their implication in tumor growth.

    abstract::Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Anghileri LJ,Martinez AC,Maleki P

    更新日期:1992-01-01 00:00:00

  • Mammalian tropism of B77(RBI) virus. Expression of virus genome in the hamster sarcoma cell clones.

    abstract::In contrast to the B77 virus, its B77(RBI) rat variant continuously produced by the rat RBI sarcoma cells in vivo and in vitro, efficiently induced progressively growing tumors in hamsters and transformed hamster embryo cells in vitro. Both, induced tumors and transformed cell cultures showed production of infectious ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Svec J,Hilubinová K,Lizorová V,Thurzo V

    更新日期:1975-01-01 00:00:00

  • Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography. II. Nucleosides of 6-azauracil.

    abstract::The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Novotný L,Vachálková A,Pískala A

    更新日期:1999-01-01 00:00:00

  • On the influence of chloramphenicol on the induction of lung adenomas by urethane in mice.

    abstract::It has been shown by a number of authors that the antibiotic chloramphenicol (CP), produced in the USSE under the name of levomycetin, had considerably inhibited the growth of liver tumors, induced by various carcinogenic compounds [3,7,8,21]. Moreover, it has been found by ourselves and other authors that CP greatly ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Shabad LM,Bogush TA,Belitsky GA

    更新日期:1975-01-01 00:00:00

  • Evidence of cell-mediated antitumor immunity in rats bearing syngeneic tumors by the leukocyte adherence inhibition test.

    abstract::A modified form of the leukocyte adherence inhibition (LAI) test has been used to follow cell-mediated immunity (CMI) in rats of the Lewis inbred strain (LW), F1 hybrids inbred strains LW x AVN with transplanted syngeneic tumors B77, MC-1, and the random-bred Sprague Dawley strain with spontaneous REF tumor. Periphera...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kalafut F,Hung PM,Novotná L,Grófová M

    更新日期:1978-01-01 00:00:00

  • Effect of inhibition of DNA synthesis on recovery of X-irradiated L5178Y-S cells, II. 9-beta-D-arabinofuranosyladenine.

    abstract::The effects of 9-beta-D-arabinofuranosyladenine (araA) on radiosensitivity, postirradiation changes in the cell cycle distribution and DNA synthesis in mouse L5178Y-S lymphoma cells are described. Increase in the araA concentration (from 25 to 200 mumol/l) was is correlated with reduction in clonogenic survival except...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kapiszewska M,Lange CS

    更新日期:1989-01-01 00:00:00

  • Production of plasminogen activator and inhibition of embryonic cell aggregation by cultured human normal and neoplastic cells.

    abstract::The plasminogen activator (PA) production and the capacity to inhibit embryonic neural retina (NR) cell aggregation by human normal and neoplastic cell lines have been studied. The PA production was detected by both iodinated fibrin and casein lysis assays, and by changes in cell morphology at the presence of activate...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Phan Thu A,Popovic M

    更新日期:1979-01-01 00:00:00

  • Activity of chromatin-bound protease in histone fractions from rat liver and Morris hepatoma.

    abstract::Activity of chromatin-bound protease of rat liver and Morris hepatoma 7777 was studied. Proteolytic enzyme was copurified with histones during extraction of chromatin with 0.25 M HCl. Total histone was fractionated by Oliver's et al. method. Histone fractions were incubated in 0.01 M Tris-HCl buffer (pH 7.6) at 37 deg...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lipińska A,Krawczyk Z,Krajewska W,Kłyszejko-Stefanowicz L,Chorazy M

    更新日期:1980-01-01 00:00:00

  • Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients.

    abstract::Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer. We intended to demonstrate and further explain the relationship between LGR5 and colon ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_016

    authors: Liu Z,Dai W,Jiang L,Cheng Y

    更新日期:2014-01-01 00:00:00

  • Risk of secondary malignancies in testicular tumors.

    abstract::The work is aimed at the occurrence of secondary malignancies after therapy for primary testicular tumors. The target of the work was determination of the number and type of secondary tumors, their effect on the survival and comparison of relative risk of the origination of secondary tumors depending on particular tre...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siffnerova H,Kralova D

    更新日期:2007-01-01 00:00:00

  • Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer - single institution experience.

    abstract::Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_513

    authors: Ban M,Viculin J,Tomic S,Capkun V,Strikic A,Mise BP,Utrobicic I,Vrdoljak E

    更新日期:2016-01-01 00:00:00

  • GRK5 promotes tumor progression in renal cell carcinoma.

    abstract::GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_180621N409

    authors: Zhao TL,Gan XX,Bao Y,Wang WP,Liu B,Wang LH

    更新日期:2019-02-06 00:00:00

  • Tumor necrosis factor-alpha: molecular-biological aspects minireview.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Szatmáry Z

    更新日期:1999-01-01 00:00:00

  • WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance.

    abstract::The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To exa...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_05_393

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    更新日期:2009-01-01 00:00:00

  • Condylomatous lesions associated with precancerous changes and carcinomas of the uterine cervix.

    abstract::The present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two Finnish hospitals. Special emphasis was placed on the detection of the newly descr...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Syrjänen KJ

    更新日期:1981-01-01 00:00:00

  • The inhibitory effect of human embryonic germ cells on ovarian cancer.

    abstract::Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...

    journal_title:Neoplasma

    pub_type: 杂志文章

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  • The expression of CD73 on pathological B-cells is associated with shorter overall survival of patients with CLL.

    abstract::CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studi...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_190826N822

    authors: Kicova M,Michalova Z,Coma M,Gabzdilova J,Dedinska K,Guman T,Bernatova S,Hajikova M,Giertlova M,Veselinyova D,Sarissky M

    更新日期:2020-07-01 00:00:00

  • The impact of positron emission tomography in the radiotherapy treatment planning. Minireview.

    abstract::Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Dolezelová H,Slampa P

    更新日期:2007-01-01 00:00:00

  • Distribution of 64copper in the blood and different tissues of mice bearing induced fibrosarcoma.

    abstract::To understand the nature of copper distribution during malignancy, 27 strains A/RB mice with fibrosarcoma were used. Tracer methodology with radioactive isotope of copper (64Cu) was applied. In the study made at different time intervals after isotope administration whole blood plasma and different tissues like liver, ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Chakravarty PK,Ghosh A,Chowdhury JR

    更新日期:1985-01-01 00:00:00

  • Primary and transplantable hepatomas induced by aflatoxin B1 in hypothyroid rats.

    abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Bednarz W

    更新日期:1989-01-01 00:00:00

  • Incidence of childhood tumors in Slovakia.

    abstract::During the decade 1968-1977 a total of 1488 cases of neoplasms were registered in Slovakia in children aged 0-14 years giving an average annual age-specific rate of 120.7 per million. Tumors prevailed in boys with 131.2 in comparison with girls showing 109.7 incidence rate/10(6). The most common malignancies were leuk...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Plesko I,Somogyi J,Dimitrova E

    更新日期:1983-01-01 00:00:00

  • Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.

    abstract::CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and ev...

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    pub_type: 杂志文章

    doi:10.4149/neo_2011_05_449

    authors: Zeng HZ,Qu YQ,Liang AB,Deng AM,Zhang WJ,Xiu B,Wang H,Wang H

    更新日期:2011-01-01 00:00:00

  • GROα expression and its prognostic implications in laryngeal squamous cell carcinoma.

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    pub_type: 杂志文章

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  • Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.

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    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Wideł M,Watras J,Suwiński J,Salwińska E

    更新日期:1987-01-01 00:00:00

  • The regulation of human adrenomedullin (AM) and tumor necrosis factor alpha (TNF-alpha) receptors on human epithelial carcinoma (HeLa) cells. The role of AM secretion in tumor cell sensitivity.

    abstract::The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...

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    pub_type: 杂志文章

    doi:

    authors: Drimal D,Drimal J,Drimal J Jr

    更新日期:2006-01-01 00:00:00