Abstract:
:In contradistinction to the increased fraction of HeLa S 3 cells in S phase after irradiation by a single dose in a range of 25--200 R, cultures irradiated by a second dose at time of morphologic restitution of mitotic activity exhibited decreased fraction of cells in S phase. The interpretation is that passage from G1 to S was reduced due to disturbances in subsystems which have not been fully repaired.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Siracká Esubject
Has Abstractpub_date
1976-01-01 00:00:00pages
629-34issue
6eissn
0028-2685issn
1338-4317journal_volume
23pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::The direct effect of selected cytostatic drugs on natural killer (NK) cell activity was evaluated. Peripheral blood mononuclear cells from healthy donors were tested for their cytolytic activity in vitro in the presence of adriamycin, methotrexate, leucovorin, vincristin, cytosine arabinoside and teniposide. Most of t...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The incidence of malignant tumors in children is not as high as that in adults, though in Cuba and other countries they are the most frequent causes of death in this age group. Data of the fourth triennial of the Registro Nacional del Cáncer (Cuban Cancer Registry) in the period 1973-1975 are presented. In the age gro...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::By the use of the dextran-coated charcoal method the presence of a high-affinity binding site for benzo(a)pyrene in the cytosol from rat liver (R strain) has been demonstrated. This binder was saturable by ligand concentration and by time. Sucrose density gradient analysis after charcoal treatment revealed one major p...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:UNLABELLED:BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; T...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_02_89
更新日期:2009-01-01 00:00:00
abstract::Projections for the incidence of all and selected major sites of cancer in the cities of Cracow and Bratislava were constructed for each year of the period 1978-1982 on the basis of data observed in the years 1968-1977. More or less increasing of unchanging trends were predicted for the malignant neoplasms of bladder,...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::In contrast to the B77 virus, its B77(RBI) rat variant continuously produced by the rat RBI sarcoma cells in vivo and in vitro, efficiently induced progressively growing tumors in hamsters and transformed hamster embryo cells in vitro. Both, induced tumors and transformed cell cultures showed production of infectious ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::It has been shown by a number of authors that the antibiotic chloramphenicol (CP), produced in the USSE under the name of levomycetin, had considerably inhibited the growth of liver tumors, induced by various carcinogenic compounds [3,7,8,21]. Moreover, it has been found by ourselves and other authors that CP greatly ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::A modified form of the leukocyte adherence inhibition (LAI) test has been used to follow cell-mediated immunity (CMI) in rats of the Lewis inbred strain (LW), F1 hybrids inbred strains LW x AVN with transplanted syngeneic tumors B77, MC-1, and the random-bred Sprague Dawley strain with spontaneous REF tumor. Periphera...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The effects of 9-beta-D-arabinofuranosyladenine (araA) on radiosensitivity, postirradiation changes in the cell cycle distribution and DNA synthesis in mouse L5178Y-S lymphoma cells are described. Increase in the araA concentration (from 25 to 200 mumol/l) was is correlated with reduction in clonogenic survival except...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The plasminogen activator (PA) production and the capacity to inhibit embryonic neural retina (NR) cell aggregation by human normal and neoplastic cell lines have been studied. The PA production was detected by both iodinated fibrin and casein lysis assays, and by changes in cell morphology at the presence of activate...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Activity of chromatin-bound protease of rat liver and Morris hepatoma 7777 was studied. Proteolytic enzyme was copurified with histones during extraction of chromatin with 0.25 M HCl. Total histone was fractionated by Oliver's et al. method. Histone fractions were incubated in 0.01 M Tris-HCl buffer (pH 7.6) at 37 deg...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer. We intended to demonstrate and further explain the relationship between LGR5 and colon ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2014_016
更新日期:2014-01-01 00:00:00
abstract::The work is aimed at the occurrence of secondary malignancies after therapy for primary testicular tumors. The target of the work was determination of the number and type of secondary tumors, their effect on the survival and comparison of relative risk of the origination of secondary tumors depending on particular tre...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_513
更新日期:2016-01-01 00:00:00
abstract::GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180621N409
更新日期:2019-02-06 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To exa...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_05_393
更新日期:2009-01-01 00:00:00
abstract::The present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two Finnish hospitals. Special emphasis was placed on the detection of the newly descr...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_01_13
更新日期:2009-01-01 00:00:00
abstract::CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studi...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190826N822
更新日期:2020-07-01 00:00:00
abstract::Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::To understand the nature of copper distribution during malignancy, 27 strains A/RB mice with fibrosarcoma were used. Tracer methodology with radioactive isotope of copper (64Cu) was applied. In the study made at different time intervals after isotope administration whole blood plasma and different tissues like liver, ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::During the decade 1968-1977 a total of 1488 cases of neoplasms were registered in Slovakia in children aged 0-14 years giving an average annual age-specific rate of 120.7 per million. Tumors prevailed in boys with 131.2 in comparison with girls showing 109.7 incidence rate/10(6). The most common malignancies were leuk...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and ev...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2011_05_449
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known abo...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_020
更新日期:2015-01-01 00:00:00
abstract::Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00