Abstract：
UNLABELLED:Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were investigated. Tissue microarrays were prepared from 203 phyllodes tumors (PT) and stained with antibodies specific for glycine decarboxylase (GLDC), phosphoserine aminotransferase 1 (PSAT1), phosphoserine phosphatase (PSPH), phosphoglycerate dehydrogenase (PHGDH), and serine hydroxymethyltransferase 1 (SHMT1). These immunohistochemical results and clinicopathologic parameters were analyzed for correlation. Numbers of benign, borderline, and malignant tumors were 155, 32, and 16, respectively. Stromal expression of PHGDH, PSAT1, PSPH, SHMT1, and GLDC increased with increasing tumor grade, and epithelial expression of SHMT1 also increased with increasing tumor grade (p<0.001, and p=0.005, respectively). On univariate analysis, positive stainings for stromal PHGDH (p<0.001), stromal PSAT1 (p<0.001), stromal PSPH (p=0.003), epithelial SHMT1 (p=0.001), stromal SHMT1 (p=0.022), and stromal GLDC (p<0.001) were each associated with shorter disease-free survival. Stromal GLDC was associated with shorter overall survival (p<0.001). In conclusion, expression of proteins related to serine and glycine metabolism increased with increasing histologic grade in stromal components of phyllodes tumor. KEYWORDS:glycine, tumor grade, metabolism, phyllodes tumor, serine.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Kwon JE,Kim DH,Jung WH,Koo JSdoi
10.4149/neo_2014_069subject
Has Abstractpub_date
2014-01-01 00:00:00pages
566-78issue
5eissn
0028-2685issn
1338-4317journal_volume
61pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:Already a trace of oxygen mediates the one-electron transfer from 3,4-benzopyrene (benzo(a)pyrene, BP) to hydrogen peroxide or to tert. butyl hydroperoxide (ROOH), leading in this way to generation of highly reactive HO X, HO2 X or RO X and RO2 X radicals in nonpolar solvents at biological temperatures. At slightly hi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Overexpressed Wilms tumor gene 1 (WT1) has been found in a majority of patients with acute myeloid leukemia (AML). The aim of this study was to confirm the applicability of WT1 expression measurement as a marker of minimal residual disease (MRD). The expression of WT1 gene was measured by real-time polymerase chain re...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2013_011
更新日期：2013-01-01 00:00:00
abstract：:Multiple ultrasonographic (USG) evaluations of abdomen were performed in 97 patients: 30 with Hodgkin's disease (HD), 60 with non-Hodgkin lymphomas (NHL) and 7 with primary gastric lymphoma (PGL) before or during chemo- or X-ray therapy. In 33% of HD patients USG was normal, while in 63% splenomegaly, in 40% hepatomeg...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The associations of several clinical factors with general survival, percentage of relapse and survival in the group of patients who relapsed were analyzed in a series of 399 Stage II breast cancer patients operated and irradiated at the Institute of Oncology and Radiobiology in Havana. In another series of 187 patient...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Rearrangement and loss of genetic material in DNA of human ductal breast carcinoma was analyzed by restriction enzyme digestion, agarose gel electrophoresis and Southern blot hybridization using 32P labeled c-Ha-ras-1 and multilocus, minisatellite 15.1.11.4 as a probe. In several cases an allelic loss of c-Ha-ras-1 lo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A total of 93 lymph nodes from 24 patients with a primary malignant non-Hodgkin lymphoma of B-cell lineage was assessed histologically with special reference to the presence or absence of neoplastic B-cells in the lymph node cortex and medulla (B-cell areas) as well as in the paracortical (T-cell area) area, and in th...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:General anaesthesia is rarely applied during fractionated radiotherapy with the exception of unco-operative patients. We performed a retrospective study to inform our current practice in anaesthesia procedures for radiotherapy application in children, brachytherapy and intraoperative radiation. The records of anaesthe...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2010_02_155
更新日期：2010-01-01 00:00:00
abstract：:The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The humoral and cellular immune status of C57BL/6 male mice and "R" male rats bearing MC-induced sarcomas were investigated in vitro, using 51Cr-releasing and mixed hemadsorption assays. Analysis was performed on mice subjected to concomitant tumor immunity (CTI) model experiments or bearing primary tumors of differen...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The activities of alanyl aminopeptidase (AAP), arginyl aminopeptidase (RAP), alpha-glutamyl aminopeptidase (EAP) and angiotensin I-converting enzyme (ACE) were investigated in primary human lung tumors of different histological types and in matched lung parenchyma. In contrast to the studied aminopeptidases whose acti...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:In a series of 52 biopsy specimens (31 endometrial carcinomas, 10 atypical endometrial hyperplasias, and 11 cases of normal endometrium), DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded material. DNA aneuploidy was detected in 2 of the 10 atypical endometrial hyperplasias and 7 of the 31 endom...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190213N116
更新日期：2020-01-01 00:00:00
abstract：:Several parameters for an optimal treatment scheme of a soluble BCG fraction (F70) were investigated. Among lung cancer patients treated with F70 a restricted selection was made of patients treated with small doses (5--10 U) every second or third month (sparing scheme) and of patients treated every month with sharply ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in ...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：10.4149/neo_2017_301
更新日期：2017-01-01 00:00:00
abstract：:The aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. Thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in Greatpoland Cancer Cente...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still seve...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_170701N452
更新日期：2018-09-19 00:00:00
abstract：:In vivo immunogenicity and in vitro species-specific membrane antigens in tumor cells treated or untreated with glutaraldehyde (GA) were studied. Two different syngeneic Syrian hamster transplantable tumor cell lines (spontaneous liver cancer and SV40-induced sarcoma) not only lost immunogenicity after GA treatment bu...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_200106N17
更新日期：2021-01-01 00:00:00
abstract：:DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:The flavonol aglycone isorhamnetin shows anti-proliferative activity in a variety of cancer cells. Previous work, from our laboratory showed that isorhamnetin inhibits the proliferation of human esophageal squamous carcinoma Eca-109 cells in vitro, but only after 72 h of exposure. This led us to propose that isorhamne...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_047
更新日期：2012-01-01 00:00:00
abstract：:The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_171203N792
更新日期：2018-09-19 00:00:00
abstract：:Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferativ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The levels of carcinoembryonic antigen (CEA) and the activities of creatine kinase isoenzyme BB (CK-BB) were assessed in 84 patients with primary lung carcinoma and in 20 patients with nonmalignant lung diseases. The level of CEA was measured by the immunoenzymatic method using monoclonal antibodies (Abbott). The acti...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Antigen-induced inhibition of leukocyte adherence is a suitable method providing information on immunological response of the tumor bearers. Leukocytes from patients' blood were tested by an in vitro method to detect cell-mediated antitumor immunity. Positive reactions of leukocytes to the specific antigen were found ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:The aim of the presented study was to evaluate the long-term outcome of breast-conserving surgery and radiation for the treatment of ductal carcinoma in situ (DCIS) and the role of the radiation boost to the tumor bed. The files of 75 women with DCIS treated by breast-conserving surgery followed by definitive radiatio...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Using the model of Sarcoma I (SaI) (H-2a) tumor allograft transplanted to normal B10 (H-2b) mice and to B10 mice pretreated with ATS, we studied the effects of anti-Thy-1,2 monoclonal antibody (MTA) and compared them with those of rabbit polyvalent antiserum against mouse thymocytes (ATS). When administered shortly be...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Cervical cancer is a multifactorial disease involving a complex interplay between genetic and environmental factors. An important role of HIF-1α in cervical cancer carcinogenesis has been studied by multiple researches. We hypothesized that there is a possible association between HIF-1α gene polymorphisms and the risk...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Treatment with interferon-alpha (IFNalpha) prolongs survival in chronic myeloid leukemia (CML). Additionally, cytarabine (AraC) can reduce the number of Ph + metaphases. Fortythree previously untreated patients with CML in chronic phase were randomly assigned to receive either. IFNalpha 2b (5 MU sqm/daily) or IFNalpha...
journal_title：Neoplasma
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2000-01-01 00:00:00
abstract：:Effect of tumor growth on the survival of circulating erythrocytes was studied in mice bearing a wide spectrum of experimental tumors. RBC half-life (t1/2), measured by 51Cr-labeling technique, decreased significantly (p less than 0.05) in all the tumor types studied, particularly in transplantable Sarcoma-180 and ben...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
