Early lead challenge and subsequent hypertension in Sprague-Dawley rats.

Abstract:

OBJECTIVE:The consequences of chronic, low grade lead (Pb) burden from earlier exposure on development of hypertension (HT) and cardiovascular disease is, at best, controversial, even though many epidemiological studies suggest the possibility. Accordingly, we examined ability of a short-term Pb challenge to cause later developing HT in rats. METHODS:We gave 12 newly weaned Sprague-Dawley rats (SD) a 1% Pb acetate solution to drink for 6 weeks, while 12 control rats drank water. The rats were further subdivided into groups consuming high and low amounts of sugar. All rats were followed for 4 months after cessation of the Pb challenge. RESULTS:Early Pb challenge caused no significant changes in body weight (BW) from controls; however, systolic blood pressures (SBP) of rats initially receiving Pb continued to rise significantly above their respective dietary controls for months after cessation of challenge. While a high sugar diet alone was associated with elevated SBP, high sugar consumers also challenged with Pb had the highest SBP. Protein excretion did not increase, suggesting, along with other evidence, a lack of significant renal damage. CONCLUSIONS:Previous exposure to Pb can cause subsequent chronic elevations in SBP.

journal_name

J Am Coll Nutr

authors

Preuss HG,Jiang G,Jones JW,Macarthy PO,Andrews PM,Gondal JA

doi

10.1080/07315724.1994.10718451

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

578-83

issue

6

eissn

0731-5724

issn

1541-1087

journal_volume

13

pub_type

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