Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection.

Abstract:

:Following massive small bowel resection, the remaining small bowel increases in mucosal weight, protein, deoxyribonucleic acid (DNA) content and absorptive function. Enteral nutrients are known to be important in stimulating this response. Recently, glutamine has been described as an essential fuel for the small intestinal mucosa and is thought to be trophic to the small bowel. We investigated if glutamine, when added to the diet in large quantities, might stimulate mucosal adaptation beyond that which normally occurs following physiologic feedings. Male Sprague-Dawley rats were placed on powdered rat chow supplemented with either 5% glutamine, 5% glycine or 5% glucose. After 4 days rats underwent 70% jejunoileal resection. Fourteen days after resection, protein, DNA and sucrase activity in the duodenum of the glutaminefed animals were all significantly lower than results from both the glycine and glucose groups. Duodenal mucosal weight was lower in the glutamine group than in the glycine group. In the ileum, DNA content was significantly lower for the glutamine group than the glycine group. These results suggest that high concentrations of glutamine in the diet can have negative effects on intestinal adaptation.

journal_name

J Am Coll Nutr

authors

Vanderhoof JA,Blackwood DJ,Mohammadpour H,Park JH

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

223-7

issue

2

eissn

0731-5724

issn

1541-1087

journal_volume

11

pub_type

杂志文章
  • Zinc metabolism in malabsorption syndromes.

    abstract::Zinc deficiency may complicate many gastrointestinal malabsorptive states. Zinc deficiency may manifest itself in a myriad of ways, ranging from skin lesions to immune dysfunction. This paper reports many of the ways in which zinc deficiency may appear in malabsorption syndromes and possible mechanisms for the develop...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1985.10720066

    authors: McClain CJ

    更新日期:1985-01-01 00:00:00

  • Sucrose Intakes and Incident Colorectal Cancer Risk among Women.

    abstract:BACKGROUND:High sucrose intakes are hypothesized to increase colorectal cancer (CRC) risk by several mechanisms, and sucrose intakes have been consistently positively associated with CRC risk in case-control studies. However, all but one prospective study reported a null sucrose-CRC association. The only prospective st...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2020.1848661

    authors: Kiran N,Prizment AE,Lazovich D,Mao Z,Bostick RM

    更新日期:2020-12-14 00:00:00

  • Impact of a resistant dextrin with a prolonged oxidation pattern on day-long ghrelin profile.

    abstract:OBJECTIVES:The effects of a new resistant dextrin ingested at breakfast on day-long metabolic parameters and ghrelin profile at subsequent lunch were investigated. METHODS:In this randomized, single-blinded, crossover study, 12 healthy men ingested a standardized breakfast with 50 g of NUTRIOSE 10, a resistant dextrin...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2011.10719945

    authors: Nazare JA,Sauvinet V,Normand S,Guérin-Deremaux L,Gabert L,Désage M,Wils D,Laville M

    更新日期:2011-02-01 00:00:00

  • Magnesium-manganese interactions caused by magnesium deficiency in rats.

    abstract:OBJECTIVE:We investigated the effect of dietary magnesium (Mg) deficiency on the nutritive utilization and tissue distribution of manganese (Mn). METHODS:Wistar rats were fed a Mg-deficient diet (56 mg/kg) for 70 day. Absorbed Mn, Mn balance and Mn content in plasma, whole blood, skeletal muscle, heart, kidney, liver,...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1999.10718886

    authors: Sanchez-Morito N,Planells E,Aranda P,Llopis J

    更新日期:1999-10-01 00:00:00

  • Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review.

    abstract::Vitamin E consists of a group of eight isomers, four tocopherols (alpha-, beta-, gamma-, delta-tocopherol) and four tocotrienols (alpha-, beta-, gamma-, delta-tocotrienol). While extensive literature has been published on the potential health benefits of alpha-tocopherol, little is known about gamma-tocopherol, the ma...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2006.10719538

    authors: Dietrich M,Traber MG,Jacques PF,Cross CE,Hu Y,Block G

    更新日期:2006-08-01 00:00:00

  • The functional food trend: what's next and what Americans think about eggs.

    abstract:OBJECTIVE:The Health Focus National Study of Public Attitudes and Actions Toward Healthy Foods is conducted every two years to identify current issues in consumer health and nutrition behavior and attitudes, to assess the trends in consumer priorities and to develop an understanding of where consumers are headed in the...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2000.10718973

    authors: Gilbert LC

    更新日期:2000-10-01 00:00:00

  • Plasma matrix metalloproteinase (MMP)-9 levels are reduced following low-calorie cranberry juice supplementation in men.

    abstract:OBJECTIVE:Matrix metalloproteinase (MMP)-9, also known as gelatinase B, is implicated in the development of hypertension and atherosclerotic plaque vulnerability to rupture, an important step in the etiology of cardiovascular diseases. Studies have suggested that flavonoid consumption may be cardioprotective, and its f...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1080/07315724.2009.10719803

    authors: Ruel G,Pomerleau S,Couture P,Lemieux S,Lamarche B,Couillard C

    更新日期:2009-12-01 00:00:00

  • Differences in diet and food habits between patients with gallstones and controls.

    abstract:OBJECTIVE:To compare the food, energy, macronutrient and micronutrient intake of patients with gallstones to those of a control group of similar demographic characteristics. DESIGN:Patient-control study. SUBJECTS:54 gallstone patients and 46 control subjects. METHODS:Two 24-hour dietary recalls and a "food frequency...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1997.10718655

    authors: Ortega RM,Fernández-Azuela M,Encinas-Sotillos A,Andrés P,López-Sobaler AM

    更新日期:1997-02-01 00:00:00

  • Doubling calcium and phosphate concentrations in neonatal parenteral nutrition solutions using monobasic potassium phosphate.

    abstract:BACKGROUND:Premature infants require high intakes of Ca and P to mimic fetal accretion rates. With the current phosphate salt used, adequate amounts cannot be provided due to the precipitation of Ca and P in TPN solutions. OBJECTIVE:To compare monobasic potassium phosphate (monobasic regimen) and monobasic plus dibasi...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2006.10719517

    authors: Wong JC,McDougal AR,Tofan M,Aulakh J,Pineault M,Chessex P

    更新日期:2006-02-01 00:00:00

  • Plasma glucose and insulin profiles in normal subjects ingesting diets of varying carbohydrate, fat, and protein content.

    abstract::The 12-hr profiles of plasma glucose and insulin concentrations in 26 normal subjects ingesting a diet high in carbohydrate, protein, or fat have been determined. The diets were isocaloric and were given as three identical meals 4 hrs apart. In males the high carbohydrate diet resulted in glucose profiles similar to t...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1985.10720086

    authors: Nuttall FQ,Gannon MC,Wald JL,Ahmed M

    更新日期:1985-01-01 00:00:00

  • Effect of beef and soy proteins on the absorption of non-heme iron and inorganic zinc in children.

    abstract:BACKGROUND:Iron and zinc deficiency remain substantial problems in small children in both developed and developing nations. Optimizing mineral absorption is an important strategy in minimizing this problem. OBJECTIVES:To assess the effects of beef and soy proteins on the bioavailability of non-heme iron and zinc in ch...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2006.10719512

    authors: Etcheverry P,Hawthorne KM,Liang LK,Abrams SA,Griffin IJ

    更新日期:2006-02-01 00:00:00

  • Weighing the evidence to formulate dietary guidelines.

    abstract::Dietary guidelines have broad implications for the health of individuals and populations. Increasingly, government agencies and medical organization that issue guidelines have pursued evidence-based approaches. These approaches emphasize a comprehensive, critical, and explicit examination of the scientific evidence th...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2006.10719578

    authors: Woolf SH

    更新日期:2006-06-01 00:00:00

  • Serum and Erythrocyte Biomarkers of Nutrient Status Correlate with Short-Term Α-Carotene, Β-Carotene, Folate, and Vegetable Intakes Estimated by Food Frequency Questionnaire in Military Recruits.

    abstract:OBJECTIVE:Food frequency questionnaires (FFQs) estimate habitual dietary intake and require evaluation in populations of interest in order to determine accuracy. Thus, the purpose of this study was to determine agreement between circulating biomarkers and FFQ estimated dietary intake in a military population consuming ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2018.1490215

    authors: Lutz LJ,Nakayama AT,Karl JP,McClung JP,Gaffney-Stomberg E

    更新日期:2019-02-01 00:00:00

  • Effects of pharmacological therapy on anthropometric and biochemical status of male and female institutionalized psychiatric patients.

    abstract:OBJECTIVE:The pathophysiological condition and potential drug interactions may influence nutritional status. Therefore, the aim of this study was to determine, separately in male and female schizophrenic subjects, the influence of neuroleptic treatment on different indices of nutritional status. DESIGN:The survey was ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1994.10718394

    authors: Martínez JA,Velasco JJ,Urbistondo MD

    更新日期:1994-04-01 00:00:00

  • Histidinemia: a biochemical variant or a disease?

    abstract::Histidemia, first described by Ghadimi in 1961, is caused by a defect in histidase. The defect results in elevated urinary excretion of histidine and its transamination products, and in high blood histidine. Blood histidine levels in histidinemic patients range from 290 to 1420 microM (normal 70-120 microM). The clini...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1993.10718291

    authors: Virmani K,Widhalm K

    更新日期:1993-04-01 00:00:00

  • Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic homozygote and heterozygote subject.

    abstract:OBJECTIVE:Sitosterolemia is a genetic disorder characterized by an increased plasma plant sterol concentration due to enhanced sterol absorption coupled with reduced steroid excretion. The purpose of the present investigation was two-fold; first to assess the effects of a "basal" low sitosterol metabolic diet on plasma...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cobb MM,Salen G,Tint GS

    更新日期:1997-12-01 00:00:00

  • Control of polyunsaturated acids in tissue lipids.

    abstract::Since the discovery in 1929 that certain polyunsaturated fatty acids (PUFA) are essential for life and health, intense investigation has revealed the multiplicity of members in each of several families of PUFA, no two of which are equivalent. The quantified nutrient requirements for the essential dietary precursors of...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1986.10720125

    authors: Holman RT

    更新日期:1986-01-01 00:00:00

  • Associations of adequate intake of calcium with diet, beverage consumption, and demographic characteristics among children and adolescents.

    abstract:OBJECTIVE:The objective of this study is to examine various factors associated with total calcium intake and percent adequate intake (% AI) of calcium by children and adolescents, with respect to age, gender, race/ethnicity, and diet and beverage choices. DESIGN:Data from the U.S. Department of Agriculture's Continuin...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719339

    authors: Storey ML,Forshee RA,Anderson PA

    更新日期:2004-02-01 00:00:00

  • Acute nutritional and intestinal changes after pelvic radiation.

    abstract:OBJECTIVE:Pelvic radiotherapy induces acute small bowel injury but its effects on nutritional status are unknown. The objective of this study was to prospectively evaluate nutritional, functional and morphologic intestinal changes, after radiotherapy. METHODS:Fifteen patients were studied before and after pelvic irrad...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2001.10719161

    authors: Pía de la Maza M,Gotteland M,Ramírez C,Araya M,Yudin T,Bunout D,Hirsch S

    更新日期:2001-12-01 00:00:00

  • The efficacy of glucomannan supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials.

    abstract:OBJECTIVE:The increased prevalence of obesity has resulted in the current high popularity of dietary supplements marketed as weight reducing agents. The efficacy of most of these supplements is not established. The soluble fiber, glucomannan, is often recommended for weight loss. The aim of this systematic review is to...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/07315724.2014.870013

    authors: Onakpoya I,Posadzki P,Ernst E

    更新日期:2014-01-01 00:00:00

  • Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial.

    abstract:OBJECTIVE:Previous interventions have reported desirable effects of diets rich in whole grains or rich in fruits and vegetables on cardiovascular disease (CVD) risk factors and weight management. However, data are lacking regarding the effect of these fiber sources separately. The aim of this randomized clinical feedin...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2018.1444520

    authors: Fatahi S,Daneshzad E,Kord-Varkaneh H,Bellissimo N,Brett NR,Azadbakht L

    更新日期:2018-09-01 00:00:00

  • Stressor states and the cation crossroads.

    abstract::Neurohormonal activation involving the hypothalamic-pituitary-adrenal axis and adrenergic nervous and renin-angiotensin-aldosterone systems is integral to stressor state-mediated homeostatic responses. The levels of effector hormones, depending upon the degree of stress, orchestrate the concordant appearance of hypoka...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2010.10719895

    authors: Weber KT,Bhattacharya SK,Newman KP,Soberman JE,Ramanathan KB,McGee JE,Malik KU,Hickerson WL

    更新日期:2010-12-01 00:00:00

  • Food intake and satiety following a serving of pulses in young men: effect of processing, recipe, and pulse variety.

    abstract:BACKGROUND:Diets containing beans have been associated with a lower risk of obesity and overweight in several dietary surveys. These results suggest a benefit might be derived from beans and other pulses, possibly due to improved satiety or satiation and therefore lowering energy intake. Such a hypothesis has not been ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2009.10719786

    authors: Wong CL,Mollard RC,Zafar TA,Luhovyy BL,Anderson GH

    更新日期:2009-10-01 00:00:00

  • The glycemic and insulinemic index of plain sweet biscuits: relationships to in vitro starch digestibility.

    abstract:BACKGROUND:Among the various classes of processed starchy foods, wheat-based cereal products exhibit a wide range in glycemic and insulinemic responses. Understanding starch behavior during cooking and processing may help identify strategies that lower postprandial glycemia and insulinemia. OBJECTIVE:To determine the ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2005.10719489

    authors: Garsetti M,Vinoy S,Lang V,Holt S,Loyer S,Brand-Miller JC

    更新日期:2005-12-01 00:00:00

  • Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico.

    abstract:BACKGROUND:Psyllium and oat bran have been shown to lower plasma LDL cholesterol levels in different populations. Hypercholesterolemia is prevalent in the Northern part of Mexico and might be associated to dietary habits and sedentary lifestyle. METHODS:Sedentary normal (cholesterol<200 mg/dL) (n=36) and hypercholeste...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.1998.10718809

    authors: Romero AL,Romero JE,Galaviz S,Fernandez ML

    更新日期:1998-12-01 00:00:00

  • Biochemical antioxidant levels respond to supplementation with an enriched drink in frail elderly people.

    abstract:OBJECTIVE:To investigate whether a drink enriched with essential vitamins and minerals can improve biochemical status of enzymatic and non-enzymatic antioxidants in frail elderly people. METHODS:A six-month randomized, double blind, placebo controlled intervention study. Frail elderly people 65 years of age or older, ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.2003.10719298

    authors: Wouters-Wesseling W,Wagenaar LW,de Groot LC,Bindels JG,van Staveren WA

    更新日期:2003-06-01 00:00:00

  • Nutritional implications in vascular endothelial cell metabolism.

    abstract::Endothelial cells interact with blood components and the abluminal tissues, thus playing an active role in many aspects of vascular function. Numerous physiologic and pathophysiologic stimuli are often mediated by nutrients that can contribute to the overall functions of endothelial cells in the regulation of vascular...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1996.10718609

    authors: Hennig B,Toborek M,McClain CJ,Diana JN

    更新日期:1996-08-01 00:00:00

  • Desire for Sweet Taste Unchanged After Eating: Evidence of a Dessert Mentality?

    abstract:BACKGROUND/OBJECTIVES:Added sugars provide calories and desirability to foods and beverages. Our aim was to test whether desire for a sweet taste would be better maintained than a desire for other tastes for 3 hours after a test meal. METHODS:Eighty-three young adults ate 2 slices of bread on 2 separate occasions afte...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2015.1117956

    authors: Harington K,Smeele R,Van Loon F,Yuan J,Haszard JJ,Drewer A,Venn BJ

    更新日期:2016-08-01 00:00:00

  • The effect of particle size of whole-grain flour on plasma glucose, insulin, glucagon and thyroid-stimulating hormone in humans.

    abstract:OBJECTIVE:Although it is well known that consumption of whole-grain foods with higher fiber content results in beneficial health effects, most Americans usually prefer bread made with white flour. Changes in bread texture and undesirable intestinal responses have been reported as reasons for avoiding consumption of who...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.1999.10718893

    authors: Behall KM,Scholfield DJ,Hallfrisch J

    更新日期:1999-12-01 00:00:00

  • Reproducibility of relative dose response (RDR) test and serum retinol and retinyl ester concentrations in children after a 2-week interval.

    abstract:OBJECTIVE:Reproducibility of the relative dose response test (RDR), a test designed to measure vitamin A status, was tested in 23 Belizean children, 5-8 years after 2-week interval during which no treatment was given. METHODS:As required for the RDR test, serum retinol concentrations were determined before and 5 hours...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1996.10718623

    authors: Apgar J,Makdani D,Sowell AL,Gunter EW,Hegar A,Rao D,Smith JC

    更新日期:1996-10-01 00:00:00