Abstract:
OBJECTIVE:This study evaluated nutrition status to determine the impact of a novel approach using elemental nutrition compared to pancrelipase administration in patients with pancreatitis. METHODS:This retrospective study included adult patients with pancreatitis who were nil per os (NPO) and received elemental nutrition from August 2008 to 2010 (n = 24) or pancrelipase enzyme supplementation (PES) plus nonelemental enteral nutrition from August 2011 to 2013 (n = 41) at a large academic medical center. The primary outcome is the percentage of diarrhea-free days. Secondary outcomes include time-to-goal enteral nutrition from the enteral nutrition initiation and pre-albumin and albumin changes pre- and postenteral nutrition. RESULTS:There were no statistically significant differences between the 2 groups in percentage of diarrhea-free days (46.80% ± 29.03% vs 53.45% ± 36.76%, p = 0.45). Additionally, there were no differences in secondary outcomes of time-to-goal enteral nutrition and pre-albumin and albumin changes pre- and postenteral nutrition. CONCLUSION:Utilizing elemental nutrition compared to PES plus nonelemental enteral nutrition in patients with pancreatitis was not associated with a significant reduction in percentage of diarrhea-free days, time-to-goal enteral nutrition, and nutrition status. A multicenter, prospective, randomized, controlled trial is warranted to further evaluate the efficacy of elemental nutrition in patients with pancreatitis.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Antigua AD,Tran J,Lemon SJ,Zhang Ydoi
10.1080/07315724.2015.1052592subject
Has Abstractpub_date
2016-05-01 00:00:00pages
334-8issue
4eissn
0731-5724issn
1541-1087journal_volume
35pub_type
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journal_title:Journal of the American College of Nutrition
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1984.10720038
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更新日期:2007-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2001.10719176
更新日期:2001-10-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2002.10719215
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2000.10718954
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2011.10720001
更新日期:2011-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718595
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1999.10718886
更新日期:1999-10-01 00:00:00
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doi:10.1080/07315724.2013.875417
更新日期:2014-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2001.10719161
更新日期:2001-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2000.10718942
更新日期:2000-08-01 00:00:00
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doi:10.1080/07315724.1997.10718645
更新日期:1997-02-01 00:00:00
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更新日期:2019-08-01 00:00:00
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doi:10.1080/07315724.2006.10719578
更新日期:2006-06-01 00:00:00
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doi:10.1080/07315724.2008.10719691
更新日期:2008-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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journal_title:Journal of the American College of Nutrition
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pub_type: 杂志文章,评审
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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更新日期:1996-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2015.1032442
更新日期:2016-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1989.10720317
更新日期:1989-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1992.10718202
更新日期:1992-02-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2006.10719524
更新日期:2006-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1990.10720411
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVES:Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxic...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1409139
更新日期:2018-07-01 00:00:00