Challenges of Administering Pancrelipase in Pancreatitis Patients.

Abstract:

OBJECTIVE:This study evaluated nutrition status to determine the impact of a novel approach using elemental nutrition compared to pancrelipase administration in patients with pancreatitis. METHODS:This retrospective study included adult patients with pancreatitis who were nil per os (NPO) and received elemental nutrition from August 2008 to 2010 (n = 24) or pancrelipase enzyme supplementation (PES) plus nonelemental enteral nutrition from August 2011 to 2013 (n = 41) at a large academic medical center. The primary outcome is the percentage of diarrhea-free days. Secondary outcomes include time-to-goal enteral nutrition from the enteral nutrition initiation and pre-albumin and albumin changes pre- and postenteral nutrition. RESULTS:There were no statistically significant differences between the 2 groups in percentage of diarrhea-free days (46.80% ± 29.03% vs 53.45% ± 36.76%, p = 0.45). Additionally, there were no differences in secondary outcomes of time-to-goal enteral nutrition and pre-albumin and albumin changes pre- and postenteral nutrition. CONCLUSION:Utilizing elemental nutrition compared to PES plus nonelemental enteral nutrition in patients with pancreatitis was not associated with a significant reduction in percentage of diarrhea-free days, time-to-goal enteral nutrition, and nutrition status. A multicenter, prospective, randomized, controlled trial is warranted to further evaluate the efficacy of elemental nutrition in patients with pancreatitis.

journal_name

J Am Coll Nutr

authors

Antigua AD,Tran J,Lemon SJ,Zhang Y

doi

10.1080/07315724.2015.1052592

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

334-8

issue

4

eissn

0731-5724

issn

1541-1087

journal_volume

35

pub_type

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