Combined Administration of l-Carnitine and Ascorbic Acid Ameliorates Cisplatin-Induced Nephrotoxicity in Rats.

Abstract:

OBJECTIVES:Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxicity. METHODS:Twenty-five male Wistar rats were divided into 5 groups of 5 rats each. Group 1, normal control. Group 2, positive control, received cisplatin (10 mg/kg/day intraperitoneally [i.p.]) for 3 days. Groups 3, 4, and 5 received cisplatin for 3 days and thereafter l-carnitine (50 mg/kg/day), vitamin C (100 mg/kg/day), or their combination, respectively, for 28 days. At the end of the study, a biochemical study was carried out in which nephrotoxicity markers, electrolytes, hematological indices, oxidative stress biomarkers, and renal histopathological alterations were evaluated. RESULTS:CIS-treated rats developed significant polyuria, increase in the plasma levels of creatinine, urea, and inorganic phosphate (Pi), alteration in hematological parameters, and decrease in plasma levels of Na+, Cl-, K+, Ca2+, and Mg2+. Measurements of 24-hour urine output demonstrated markedly decreased creatinine and urea and increased Na+, Cl-, K+, Ca2+, and Mg2+ levels in the CIS-treated group, whereas Pi levels were not changed. It also caused significantly decreased catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH) levels in the rats' kidneys. Histopathological scores revealed renal tubular damage in CIS-treated rats. However, l-carnitine, vitamin C, or their combination significantly attenuated the alterations caused by CIS in the plasma and kidneys of the rats. CONCLUSION:l-Carnitine and vitamin C administration ameliorated CIS-induced nephrotoxicity due to their antioxidant and anti-inflammatory effects.

journal_name

J Am Coll Nutr

authors

Alabi QK,Akomolafe RO,Olukiran OS,Nafiu AO,Adefisayo MA,Owotomo OI,Omole JG,Olamilosoye KP

doi

10.1080/07315724.2017.1409139

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

387-398

issue

5

eissn

0731-5724

issn

1541-1087

journal_volume

37

pub_type

杂志文章
  • Dietary carbohydrates and cardiovascular disease risk factors in the Framingham offspring cohort.

    abstract:OBJECTIVE:Evidence from observational studies has suggested that carbohydrate quality rather than absolute intake is associated with greater risk of chronic diseases. The aim of this study was to examine the relationship between carbohydrate intake and dietary glycemic index and several cardiovascular disease risk fact...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2009.10719766

    authors: McKeown NM,Meigs JB,Liu S,Rogers G,Yoshida M,Saltzman E,Jacques PF

    更新日期:2009-04-01 00:00:00

  • The Thermic Effect of Food: A Review.

    abstract::Two-thirds of U.S. adults are overweight. There is an urgent need for effective methods for weight management. A potentially modifiable component of energy expenditure is the thermic effect of food (TEF), the increase in the metabolic rate that occurs after a meal. Evidence suggests that TEF is increased by larger mea...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2018.1552544

    authors: Calcagno M,Kahleova H,Alwarith J,Burgess NN,Flores RA,Busta ML,Barnard ND

    更新日期:2019-08-01 00:00:00

  • Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides.

    abstract:BACKGROUND:It is unclear whether other ginseng sources can replicate the glycemic-lowering efficacy observed previously with American ginseng and whether ginsenosides are mediators. We assessed the effect of eight popular ginseng types on postprandial plasma glucose (PG) and insulin (PI) indices, linking effects to gin...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.2004.10719368

    authors: Sievenpiper JL,Arnason JT,Leiter LA,Vuksan V

    更新日期:2004-06-01 00:00:00

  • Differences in diet and food habits between patients with gallstones and controls.

    abstract:OBJECTIVE:To compare the food, energy, macronutrient and micronutrient intake of patients with gallstones to those of a control group of similar demographic characteristics. DESIGN:Patient-control study. SUBJECTS:54 gallstone patients and 46 control subjects. METHODS:Two 24-hour dietary recalls and a "food frequency...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1997.10718655

    authors: Ortega RM,Fernández-Azuela M,Encinas-Sotillos A,Andrés P,López-Sobaler AM

    更新日期:1997-02-01 00:00:00

  • Finding consensus in the dietary calcium-blood pressure debate.

    abstract::No single study or avenue of investigation can resolve the scientific controversies that entangle efforts to determine the effects of specific nutrients on medical conditions. To reach consensus in this area requires a substantial body of plausible, reproducible and consistent data from various investigative approache...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1999.10718904

    authors: McCarron DA,Reusser ME

    更新日期:1999-10-01 00:00:00

  • Is serum albumin a marker of malnutrition in chronic disease? The scleroderma paradigm.

    abstract:BACKGROUND:Malnutrition is common in many chronic diseases, but physicians may rely on a low albumin value before deciding that malnutrition is present. OBJECTIVE:To determine the relationship between serum albumin and malnutrition in systemic sclerosis (SSc) as a paradigm for other chronic diseases. DESIGN:Cross-sec...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1080/07315724.2010.10719828

    authors: Baron M,Hudson M,Steele R,Canadian Scleroderma Research Group (CSRG).

    更新日期:2010-04-01 00:00:00

  • Repeated Sprints in Fasted State Impair Reaction Time Performance.

    abstract:OBJECTIVE:The aim of this study was to assess the effects of 3-day Islamic intermittent fasting (3d-IF) on cognitive performance and serum levels of neurotrophic factors (brain-derived neurotrophic factor [BDNF] and vascular endothelial growth factor [VEGF]) before and after repeated sprints. METHODS:Twenty-one physic...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2016.1256795

    authors: Cherif A,Meeusen R,Farooq A,Briki W,Fenneni MA,Chamari K,Roelands B

    更新日期:2017-03-01 00:00:00

  • Impact of Diets Rich in Whole Grains and Fruits and Vegetables on Cardiovascular Risk Factors in Overweight and Obese Women: A Randomized Clinical Feeding Trial.

    abstract:OBJECTIVE:Previous interventions have reported desirable effects of diets rich in whole grains or rich in fruits and vegetables on cardiovascular disease (CVD) risk factors and weight management. However, data are lacking regarding the effect of these fiber sources separately. The aim of this randomized clinical feedin...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2018.1444520

    authors: Fatahi S,Daneshzad E,Kord-Varkaneh H,Bellissimo N,Brett NR,Azadbakht L

    更新日期:2018-09-01 00:00:00

  • A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats.

    abstract:OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular fr...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719398

    authors: Vink R,Donkin JJ,Cruz MI,Nimmo AJ,Cernak I

    更新日期:2004-10-01 00:00:00

  • Histidinemia: a biochemical variant or a disease?

    abstract::Histidemia, first described by Ghadimi in 1961, is caused by a defect in histidase. The defect results in elevated urinary excretion of histidine and its transamination products, and in high blood histidine. Blood histidine levels in histidinemic patients range from 290 to 1420 microM (normal 70-120 microM). The clini...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1993.10718291

    authors: Virmani K,Widhalm K

    更新日期:1993-04-01 00:00:00

  • Absorption and effect of the magnesium content of a mineral water in the human body.

    abstract:OBJECTIVE:The kinetics of magnesium (Mg) absorption, after drinking Magnesia mineral water (204 mg Mg/L), was investigated in healthy humans aged (23-60 yrs). METHODS:Serum Mg, calcium (Ca), potassium (K) and sodium (Na) content, blood hemoglobin, erythrocyte and white blood cell counts as well as urinary volume and u...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719424

    authors: Kiss SA,Forster T,Dongó A

    更新日期:2004-12-01 00:00:00

  • Saccharide Composition of Carbohydrates Consumed during an Ultra-endurance Triathlon.

    abstract:OBJECTIVE:Ingesting a mix of glucose and fructose during exercise increases exogenous carbohydrate oxidation while minimizing gastrointestinal (GI) distress. Several studies have suggested that a glucose-to-fructose ratio of 1.2:1 to 1:1 is optimal. No studies have quantified saccharides consumed during a nonsimulated ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2014.996830

    authors: Wilson PB,Rhodes GS,Ingraham SJ

    更新日期:2015-01-01 00:00:00

  • Serum insulin-like growth factor-I concentrations in the recovery of patients with anorexia nervosa.

    abstract::Anorexia nervosa (AN) can result in extreme malnutrition, and these patients frequently require inordinately large amounts of calories to gain weight during refeeding therapy. Insulin-like growth factor-I (IGF-I) is a polypeptide that mediates many of the anabolic effects of growth hormone. Low levels of IGF-I have be...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1993.10718338

    authors: Hill KK,Hill DB,McClain MP,Humphries LL,McClain CJ

    更新日期:1993-08-01 00:00:00

  • Extensive laboratory assessment of nutritional status in fit, health-conscious, elderly people living in the Paris area. Research Group on Aging.

    abstract:OBJECTIVE:Nutritional status-related biological indexes were measured in fit, health-conscious elderly subjects in order to establish reference values for people over 70 years. SUBJECTS:103 men and 90 women aged 70-89 years living freely in the Paris area volunteered to participate. METHODS:Nutritional status was ass...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1994.10718461

    authors: Cals MJ,Bories PN,Devanlay M,Desveaux N,Luciani L,Succari M,Duche JC,de Jaeger C,Blonde-Cynober F,Coudray-Lucas C

    更新日期:1994-12-01 00:00:00

  • An investigation of hormone and lipid associations after weight loss in women.

    abstract:OBJECTIVE:The objectives of this study were to determine 1) whether the extent of weight loss is predictive of the degree of changes in hormone and lipid levels; 2) the interactions between energy regulating hormones after weight loss through an energy deficit/exercise protocol diet and exercise; 3) whether initial met...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2007.10719608

    authors: Santosa S,Demonty I,Lichtenstein AH,Cianflone K,Jones PJ

    更新日期:2007-06-01 00:00:00

  • A simple ashing method for determination of Mg and Ca in laboratory animal feed and tissues.

    abstract::A simple procedure has been developed for preparation of animal tissues and diet mixtures for Mg and Ca analysis by atomic absorption spectroscopy. This procedure involves wet ashing in warm 30% hydrogen peroxide and extraction of metals, from the dried ash, into cold, dilute nitric acid. Less than 200 mg of tissue or...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1983.10719920

    authors: Chang C,Bloom S

    更新日期:1983-01-01 00:00:00

  • The glycemic and insulinemic index of plain sweet biscuits: relationships to in vitro starch digestibility.

    abstract:BACKGROUND:Among the various classes of processed starchy foods, wheat-based cereal products exhibit a wide range in glycemic and insulinemic responses. Understanding starch behavior during cooking and processing may help identify strategies that lower postprandial glycemia and insulinemia. OBJECTIVE:To determine the ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2005.10719489

    authors: Garsetti M,Vinoy S,Lang V,Holt S,Loyer S,Brand-Miller JC

    更新日期:2005-12-01 00:00:00

  • Consumption Safety of Pastries, Confectioneries, and Potato Products as Related to Fat Content.

    abstract:STUDY AIM:To determine the content of the main groups of fatty acids in pastries, confectionery, and potato products, paying special attention to trans fatty acids and the products of fat oxidation and hydrolysis, as factors affecting the safety of consumption. METHODS:A total of 157 products were collected in Poland ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2014.942472

    authors: Żbikowska A,Rutkowska J,Kowalska M

    更新日期:2015-01-01 00:00:00

  • Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial.

    abstract:BACKGROUND:Foods that enhance satiety can help consumers to resist environmental cues to eat and help adherence to calorie restriction. The objective of this study was to compare the effect of 2 oat-based breakfast cereals on appetite, satiety, and food intake. METHODS:Forty-eight healthy individuals, 18 years of age ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2015.1032442

    authors: Rebello CJ,Johnson WD,Martin CK,Han H,Chu YF,Bordenave N,van Klinken BJ,O'Shea M,Greenway FL

    更新日期:2016-01-01 00:00:00

  • Weight loss is correlated with an improved lipoprotein profile in obese postmenopausal women.

    abstract:BACKGROUND:Changes in plasma lipid and lipoprotein distributions that occur after menopause increase the risk of cardiovascular disease in women, especially in those who are overweight. OBJECTIVE:The purpose of this study was to evaluate the impact of a nine-month weight reduction program on plasma lipids, dietary int...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.2000.10718927

    authors: Cordero-MacIntyre ZR,Lohman TG,Rosen J,Peters W,España RC,Dickinson B,Reid PM,Howell WH,Fernandez ML

    更新日期:2000-04-01 00:00:00

  • Comparative effect of dietary sitosterol on plasma sterols and cholesterol and bile acid synthesis in a sitosterolemic homozygote and heterozygote subject.

    abstract:OBJECTIVE:Sitosterolemia is a genetic disorder characterized by an increased plasma plant sterol concentration due to enhanced sterol absorption coupled with reduced steroid excretion. The purpose of the present investigation was two-fold; first to assess the effects of a "basal" low sitosterol metabolic diet on plasma...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cobb MM,Salen G,Tint GS

    更新日期:1997-12-01 00:00:00

  • Iron and protein sufficiency and red cell indices in phenylketonuria.

    abstract:OBJECTIVE AND METHODS:We reviewed records of 41 children with treated phenylketonuria (PKU) in order to evaluate hematopoiesis and the effect of iron and protein sufficiency. RESULTS:Six children (15%) were found to have anemia. Combined depletion of iron and protein stores was most likely to result in anemia, and two...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2001.10719016

    authors: Arnold GL,Kirby R,Preston C,Blakely E

    更新日期:2001-02-01 00:00:00

  • The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study.

    abstract:BACKGROUND:Carotenoids are mainly carried by lipoproteins in blood, however little is known about the influence of polymorphisms of apolipoproteins (apo), cholesterol ester transfer protein (CETP) and lipoprotein lipase (LPL) involved in serum lipid metabolism. OBJECTIVE:We aimed to analyze whether serum concentration...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2007.10719644

    authors: Herbeth B,Gueguen S,Leroy P,Siest G,Visvikis-Siest S

    更新日期:2007-12-01 00:00:00

  • Extreme running competition decreases blood antioxidant defense capacity.

    abstract:OBJECTIVE:We tested whether an extreme running competition ("Marathon of Sands") might alter the blood's enzymatic and non-enzymatic antioxidant status in 6 well-trained athletes. METHODS:The Marathon of Sands is a competition consisting of six long duration races in the desert in which the athletes carry their own fo...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719379

    authors: Machefer G,Groussard C,Rannou-Bekono F,Zouhal H,Faure H,Vincent S,Cillard J,Gratas-Delamarche A

    更新日期:2004-08-01 00:00:00

  • Acute effect of black and green tea on aortic stiffness and wave reflections.

    abstract:OBJECTIVE:While most studies have shown an inverse relation between tea consumption and cardiovascular risk, other studies have shown opposite results. Aortic stiffness and wave reflections are markers of cardiovascular disease and prognosticators of cardiovascular risk. METHODS:The acute effect of black and green tea...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2006.10719535

    authors: Vlachopoulos C,Alexopoulos N,Dima I,Aznaouridis K,Andreadou I,Stefanadis C

    更新日期:2006-06-01 00:00:00

  • The Association Between Dietary Glycemic Index and Glycemic Load and a Body Shape and Fat Distribution Among Apparently Healthy Iranian Adults.

    abstract:OBJECTIVE:The role of dietary glycemic index (GI) and glycemic load (GL) in the development of obesity has been debated globally. The relationship with body shape and fat distribution was examined in this cross-sectional association study among apparently healthy Iranian adults. METHODS AND MATERIALS:A study populatio...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2017.1416312

    authors: Fuseini AM,Rahimi MH,Mollahosseini M,Yekaninejad MS,Maghbooli Z,Mirzaei K

    更新日期:2018-07-01 00:00:00

  • Serum zinc and copper: associations with cholesterol and triglyceride levels in children and adolescents. Cardiovascular risk in young Finns.

    abstract::Associations among serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and levels of serum zinc (S-Zn), serum copper (S-Cu), and their ratio were analyzed in 3373 3-, 6-, 9-, 12-, 15-, and 18-year-old Finnish girls and boys. S-Zn was positively related to total cholesterol, HDL-choles...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1989.10720314

    authors: Laitinen R,Vuori E,Viikari J

    更新日期:1989-10-01 00:00:00

  • Brief communication: clinical experience with high branched-chain parenteral nutrition.

    abstract::Patients who appear to respond best to high branched-chain amino acid (BCAA) solutions have been previously described by objective measurements such as total urinary nitrogen (TUN) excretion, oxygen consumption index (O2Cl), plasma lactate, plasma pyruvate, plasma glucose (PG) and urinary 3-methylhistidine. Use of the...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1992.10718192

    authors: Mattox TW,Teasley-Strausburg KM

    更新日期:1992-02-01 00:00:00

  • Predictors of postmenopausal body mass index and waist hip ratio in the oklahoma postmenopausal health disparities study.

    abstract:OBJECTIVE:The goal of the current study has been to examine systematically the respective roles of nutrition, exercise, menopausal weight gain, moderate drinking and smoking as determinants of body mass index (BMI) and waist hip ratio (WHR) in a setting in which the role of race or ethnic group could be simultaneously ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2003.10719303

    authors: Gavaler JS,Rosenblum E

    更新日期:2003-08-01 00:00:00

  • Polyunsaturated fats enhance peripheral glucose utilization in rats.

    abstract::Carbohydrate intolerance is positively correlated with saturated fat consumption. In contrast, individuals consuming diets comprised of polyunsaturated fatty acids (PUFA) have a lower incidence of diabetes mellitus (DM). To test the hypothesis that dietary fats may influence insulin sensitivity, insulin-stimulated glu...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1991.10718161

    authors: Lardinois CK,Starich GH

    更新日期:1991-08-01 00:00:00