Abstract:
OBJECTIVES:Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxicity. METHODS:Twenty-five male Wistar rats were divided into 5 groups of 5 rats each. Group 1, normal control. Group 2, positive control, received cisplatin (10 mg/kg/day intraperitoneally [i.p.]) for 3 days. Groups 3, 4, and 5 received cisplatin for 3 days and thereafter l-carnitine (50 mg/kg/day), vitamin C (100 mg/kg/day), or their combination, respectively, for 28 days. At the end of the study, a biochemical study was carried out in which nephrotoxicity markers, electrolytes, hematological indices, oxidative stress biomarkers, and renal histopathological alterations were evaluated. RESULTS:CIS-treated rats developed significant polyuria, increase in the plasma levels of creatinine, urea, and inorganic phosphate (Pi), alteration in hematological parameters, and decrease in plasma levels of Na+, Cl-, K+, Ca2+, and Mg2+. Measurements of 24-hour urine output demonstrated markedly decreased creatinine and urea and increased Na+, Cl-, K+, Ca2+, and Mg2+ levels in the CIS-treated group, whereas Pi levels were not changed. It also caused significantly decreased catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH) levels in the rats' kidneys. Histopathological scores revealed renal tubular damage in CIS-treated rats. However, l-carnitine, vitamin C, or their combination significantly attenuated the alterations caused by CIS in the plasma and kidneys of the rats. CONCLUSION:l-Carnitine and vitamin C administration ameliorated CIS-induced nephrotoxicity due to their antioxidant and anti-inflammatory effects.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Alabi QK,Akomolafe RO,Olukiran OS,Nafiu AO,Adefisayo MA,Owotomo OI,Omole JG,Olamilosoye KPdoi
10.1080/07315724.2017.1409139subject
Has Abstractpub_date
2018-07-01 00:00:00pages
387-398issue
5eissn
0731-5724issn
1541-1087journal_volume
37pub_type
杂志文章abstract:OBJECTIVE:Evidence from observational studies has suggested that carbohydrate quality rather than absolute intake is associated with greater risk of chronic diseases. The aim of this study was to examine the relationship between carbohydrate intake and dietary glycemic index and several cardiovascular disease risk fact...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2009.10719766
更新日期:2009-04-01 00:00:00
abstract::Two-thirds of U.S. adults are overweight. There is an urgent need for effective methods for weight management. A potentially modifiable component of energy expenditure is the thermic effect of food (TEF), the increase in the metabolic rate that occurs after a meal. Evidence suggests that TEF is increased by larger mea...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2018.1552544
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:It is unclear whether other ginseng sources can replicate the glycemic-lowering efficacy observed previously with American ginseng and whether ginsenosides are mediators. We assessed the effect of eight popular ginseng types on postprandial plasma glucose (PG) and insulin (PI) indices, linking effects to gin...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.2004.10719368
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To compare the food, energy, macronutrient and micronutrient intake of patients with gallstones to those of a control group of similar demographic characteristics. DESIGN:Patient-control study. SUBJECTS:54 gallstone patients and 46 control subjects. METHODS:Two 24-hour dietary recalls and a "food frequency...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1997.10718655
更新日期:1997-02-01 00:00:00
abstract::No single study or avenue of investigation can resolve the scientific controversies that entangle efforts to determine the effects of specific nutrients on medical conditions. To reach consensus in this area requires a substantial body of plausible, reproducible and consistent data from various investigative approache...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1999.10718904
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Malnutrition is common in many chronic diseases, but physicians may rely on a low albumin value before deciding that malnutrition is present. OBJECTIVE:To determine the relationship between serum albumin and malnutrition in systemic sclerosis (SSc) as a paradigm for other chronic diseases. DESIGN:Cross-sec...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,多中心研究
doi:10.1080/07315724.2010.10719828
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the effects of 3-day Islamic intermittent fasting (3d-IF) on cognitive performance and serum levels of neurotrophic factors (brain-derived neurotrophic factor [BDNF] and vascular endothelial growth factor [VEGF]) before and after repeated sprints. METHODS:Twenty-one physic...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2016.1256795
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Previous interventions have reported desirable effects of diets rich in whole grains or rich in fruits and vegetables on cardiovascular disease (CVD) risk factors and weight management. However, data are lacking regarding the effect of these fiber sources separately. The aim of this randomized clinical feedin...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2018.1444520
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular fr...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719398
更新日期:2004-10-01 00:00:00
abstract::Histidemia, first described by Ghadimi in 1961, is caused by a defect in histidase. The defect results in elevated urinary excretion of histidine and its transamination products, and in high blood histidine. Blood histidine levels in histidinemic patients range from 290 to 1420 microM (normal 70-120 microM). The clini...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1993.10718291
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:The kinetics of magnesium (Mg) absorption, after drinking Magnesia mineral water (204 mg Mg/L), was investigated in healthy humans aged (23-60 yrs). METHODS:Serum Mg, calcium (Ca), potassium (K) and sodium (Na) content, blood hemoglobin, erythrocyte and white blood cell counts as well as urinary volume and u...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719424
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Ingesting a mix of glucose and fructose during exercise increases exogenous carbohydrate oxidation while minimizing gastrointestinal (GI) distress. Several studies have suggested that a glucose-to-fructose ratio of 1.2:1 to 1:1 is optimal. No studies have quantified saccharides consumed during a nonsimulated ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.996830
更新日期:2015-01-01 00:00:00
abstract::Anorexia nervosa (AN) can result in extreme malnutrition, and these patients frequently require inordinately large amounts of calories to gain weight during refeeding therapy. Insulin-like growth factor-I (IGF-I) is a polypeptide that mediates many of the anabolic effects of growth hormone. Low levels of IGF-I have be...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1993.10718338
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:Nutritional status-related biological indexes were measured in fit, health-conscious elderly subjects in order to establish reference values for people over 70 years. SUBJECTS:103 men and 90 women aged 70-89 years living freely in the Paris area volunteered to participate. METHODS:Nutritional status was ass...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1994.10718461
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to determine 1) whether the extent of weight loss is predictive of the degree of changes in hormone and lipid levels; 2) the interactions between energy regulating hormones after weight loss through an energy deficit/exercise protocol diet and exercise; 3) whether initial met...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2007.10719608
更新日期:2007-06-01 00:00:00
abstract::A simple procedure has been developed for preparation of animal tissues and diet mixtures for Mg and Ca analysis by atomic absorption spectroscopy. This procedure involves wet ashing in warm 30% hydrogen peroxide and extraction of metals, from the dried ash, into cold, dilute nitric acid. Less than 200 mg of tissue or...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1983.10719920
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Among the various classes of processed starchy foods, wheat-based cereal products exhibit a wide range in glycemic and insulinemic responses. Understanding starch behavior during cooking and processing may help identify strategies that lower postprandial glycemia and insulinemia. OBJECTIVE:To determine the ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2005.10719489
更新日期:2005-12-01 00:00:00
abstract:STUDY AIM:To determine the content of the main groups of fatty acids in pastries, confectionery, and potato products, paying special attention to trans fatty acids and the products of fat oxidation and hydrolysis, as factors affecting the safety of consumption. METHODS:A total of 157 products were collected in Poland ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.942472
更新日期:2015-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2015.1032442
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Changes in plasma lipid and lipoprotein distributions that occur after menopause increase the risk of cardiovascular disease in women, especially in those who are overweight. OBJECTIVE:The purpose of this study was to evaluate the impact of a nine-month weight reduction program on plasma lipids, dietary int...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.2000.10718927
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Sitosterolemia is a genetic disorder characterized by an increased plasma plant sterol concentration due to enhanced sterol absorption coupled with reduced steroid excretion. The purpose of the present investigation was two-fold; first to assess the effects of a "basal" low sitosterol metabolic diet on plasma...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE AND METHODS:We reviewed records of 41 children with treated phenylketonuria (PKU) in order to evaluate hematopoiesis and the effect of iron and protein sufficiency. RESULTS:Six children (15%) were found to have anemia. Combined depletion of iron and protein stores was most likely to result in anemia, and two...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2001.10719016
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Carotenoids are mainly carried by lipoproteins in blood, however little is known about the influence of polymorphisms of apolipoproteins (apo), cholesterol ester transfer protein (CETP) and lipoprotein lipase (LPL) involved in serum lipid metabolism. OBJECTIVE:We aimed to analyze whether serum concentration...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2007.10719644
更新日期:2007-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719379
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:While most studies have shown an inverse relation between tea consumption and cardiovascular risk, other studies have shown opposite results. Aortic stiffness and wave reflections are markers of cardiovascular disease and prognosticators of cardiovascular risk. METHODS:The acute effect of black and green tea...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2006.10719535
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:The role of dietary glycemic index (GI) and glycemic load (GL) in the development of obesity has been debated globally. The relationship with body shape and fat distribution was examined in this cross-sectional association study among apparently healthy Iranian adults. METHODS AND MATERIALS:A study populatio...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1416312
更新日期:2018-07-01 00:00:00
abstract::Associations among serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and levels of serum zinc (S-Zn), serum copper (S-Cu), and their ratio were analyzed in 3373 3-, 6-, 9-, 12-, 15-, and 18-year-old Finnish girls and boys. S-Zn was positively related to total cholesterol, HDL-choles...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1989.10720314
更新日期:1989-10-01 00:00:00
abstract::Patients who appear to respond best to high branched-chain amino acid (BCAA) solutions have been previously described by objective measurements such as total urinary nitrogen (TUN) excretion, oxygen consumption index (O2Cl), plasma lactate, plasma pyruvate, plasma glucose (PG) and urinary 3-methylhistidine. Use of the...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1992.10718192
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:The goal of the current study has been to examine systematically the respective roles of nutrition, exercise, menopausal weight gain, moderate drinking and smoking as determinants of body mass index (BMI) and waist hip ratio (WHR) in a setting in which the role of race or ethnic group could be simultaneously ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2003.10719303
更新日期:2003-08-01 00:00:00
abstract::Carbohydrate intolerance is positively correlated with saturated fat consumption. In contrast, individuals consuming diets comprised of polyunsaturated fatty acids (PUFA) have a lower incidence of diabetes mellitus (DM). To test the hypothesis that dietary fats may influence insulin sensitivity, insulin-stimulated glu...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1991.10718161
更新日期:1991-08-01 00:00:00