Abstract:
OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular free magnesium (Mg(f)) decline is known to occur and has been correlated with functional outcome. We therefore examined whether a substance P antagonist restores brain intracellular free magnesium concentration following TBI. METHODS:Male, adult Sprague-Dawley rats were injured using the Cernak impact acceleration model of diffuse TBI. At 30 min after injury, animals were administered either 0.25 mg/kg i.v. n-acetyl tryptophan or equal volume saline. Prior to and 4 h after induction of injury, phosphorus magnetic resonance spectra were acquired using a 7-tesla magnet interfaced with a Bruker console. Mg(f) was calculated from the chemical shift of the beta ATP. Before injury, Mg(f) was 0.51 +/- 0.05 mM (SEM). RESULTS:By 4 hr after injury, Mg(f) had significantly declined to 0.27 +/- 0.02 mM in saline treated rats. In contrast, rats treated with n-acetyl tryptophan had a Mg(f) of 0.47 +/- 0.06 mM at 4 h after injury, which was not significantly different from preinjury values. There were no significant differences in pH between the treatment groups. CONCLUSION:It seems that any beneficial effect of a substance P antagonist on functional outcome following TBI may be related to improvement in brain Mg homeostasis induced by the compound.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Vink R,Donkin JJ,Cruz MI,Nimmo AJ,Cernak Idoi
10.1080/07315724.2004.10719398subject
Has Abstractpub_date
2004-10-01 00:00:00pages
538S-540Sissue
5eissn
0731-5724issn
1541-1087pii
23/5/538Sjournal_volume
23pub_type
杂志文章abstract:OBJECTIVE:To determine measured resting energy expenditure (REE) of nonambulatory tube-fed patients with severe neurological neurodevelopmental disabilities. METHODS:Twenty patients were prospectively studied. Only steady state indirect calorimetry measurements were taken. All measurements were conducted using a canop...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1999.10718828
更新日期:1999-02-01 00:00:00
abstract::Vitamin A deficiency is one of the most widespread nutritional deficiencies worldwide. Hundreds of millions of children and tens of millions of women living in Sub-Saharan Africa and Southeast Asia are at particularly high risk of the adverse health consequences associated with this largely preventable condition. Red ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2010.10719845
更新日期:2010-06-01 00:00:00
abstract::Objective: Vitamin D (vitD) mediates numerous health conditions other than bone health and mineralization. Its role in cardiometabolic condition is still inconclusive. Methods: We conducted a cross-sectional study in 87 apparently healthy Serbian adults. We assessed their dietary intake, anthropometric and biochemical...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2018.1538828
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:NutriBee was the first clinical nutrition intervention designed to bring the Institute of Medicine recommendations for 20 hours of experiential nutrition-themed learning to grades 4-7 into club and camp settings. We piloted NutriBee to assess acceptability and impact among early adolescents in diverse and dis...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2015.1110507
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Intakes of ready-to-eat cereal (RTEC) have been inversely associated with risk factors of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes, and certain cancers; however, their relations with total and cause-specific mortality remain unclear. OBJECTIVE:To prospectively assess the associ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.971193
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To compare the effect of an experimental viscous fiber (VF) crispy bar on the postprandial glucose, insulin, and C-peptide response in adult subjects with type 2 diabetes to two commercially available control crispy bars. DESIGN:The study was a randomized, double-blinded, three period, crossover study. SETT...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/07315724.2006.10719553
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients. However, patient compliance is poor because bad-tasting fish oils are used as an n-3 PUFA source. Therefore, we explored whether the beneficial...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章
doi:10.1080/07315724.2013.826482
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to determine 1) whether the extent of weight loss is predictive of the degree of changes in hormone and lipid levels; 2) the interactions between energy regulating hormones after weight loss through an energy deficit/exercise protocol diet and exercise; 3) whether initial met...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2007.10719608
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Food frequency questionnaires (FFQs) estimate habitual dietary intake and require evaluation in populations of interest in order to determine accuracy. Thus, the purpose of this study was to determine agreement between circulating biomarkers and FFQ estimated dietary intake in a military population consuming ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2018.1490215
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The link between stress-related increases in inflammatory markers, hepcidin, and iron status are poorly understood, especially in developing countries like India. The aim of the study was to examine the relationship between adolescent life-event stress (ALES), inflammatory markers, and its association with he...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2013.875417
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The study tested the hypothesis that inclusion of palm olein (45% of fat) in the fat blend of a milk-based infant formula decreases the absorption of fat and calcium. METHODS:Formula PO contained palm olein (45%) in addition to soy, coconut and high-oleic sunflower oils (20%, 20%, and 15%, respectively); For...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1998.10718770
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that plasma and urinary free choline concentrations decrease significantly during a marathon, and that these decreases may be associated with decreased performance. OBJECTIVE:In a pilot study, we sought to determine whether lecithin supplementation prior to a marathon would maint...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.2000.10718076
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:Our objective was to evaluate the effect of regular use of nutritional supplements on serum vitamin C levels in a multivariable regression model, taking into account other dietary and demographic variables which may affect nutritional status. METHODS:We analyzed NHANES II data for subjects age 3 to 74. Analy...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1994.10718367
更新日期:1994-02-01 00:00:00
abstract::Osteoporosis is a multifactorial disease with dimensions of genetics, endocrine function, exercise and nutritional considerations. Of particular considerations are calcium (Ca) status, Vitamin D, fluoride, magnesium and other trace elements. Several trace elements, particularly copper (Cu), manganese (Mn) and zinc (Zn...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1993.10718327
更新日期:1993-08-01 00:00:00
abstract::The tenth anniversary for the determination of magnesium in MBC shows progress, but fundamental questions are still unanswered. Uniformity of the methodology for the assay and the units for reporting the result is a key factor for the validity and comparability of results. There is relatively good agreement among inve...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1987.10720166
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:While not life threatening, muscle cramps severely affect the quality of life of patients with cirrhosis. AIM:To determine whether oral zinc sulfate therapy decreases the frequency and severity of muscle cramps in cirrhotic patients. METHODS:12 patients with cirrhosis (5 Child's A, 3 Child's B, and 4 Child...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章
doi:10.1080/07315724.2000.10718908
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:There is limited information on the nutritional health of Canadian children, particularly those living in poverty. Our purpose was to assess the dietary and anthropometric status of economically disadvantaged children as part of the longitudinal, multidisciplinary prevention project, Better Beginnings, Better...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1995.10718548
更新日期:1995-12-01 00:00:00
abstract::The weight loss of 16 obese patients (greater than 130% ideal body weight) who participated for three months in a comprehensive, multidisciplinary weight reduction program was studied. Patients were divided into two groups based on the reported time of onset of their obesity. Childhood-onset obesity was defined in thi...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1982.10718986
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Postprandial hyperglycemia has been associated with increased oxidative stress and the development of diabetes, heart disease and all-cause mortality. OBJECTIVE:To assess the effect of novel maize-based dietary fibers on postprandial glycemia and to assess the correlation between a rapid in vitro digestibil...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章
doi:10.1080/07315724.2008.10719748
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Among the various classes of processed starchy foods, wheat-based cereal products exhibit a wide range in glycemic and insulinemic responses. Understanding starch behavior during cooking and processing may help identify strategies that lower postprandial glycemia and insulinemia. OBJECTIVE:To determine the ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2005.10719489
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:β-alanine (BA) is a nonproteogenic amino acid that combines with histidine to form carnosine. The amount taken orally in individual doses, however, is limited due to symptoms of paresthesia that are associated with higher doses. The use of a sustained-release formulation has been reported to reduce the sympto...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2017.1335250
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:In Sprague-Dawley rats (SD), we compared two categories of natural dietary supplements that influence carbohydrate (CHO) metabolism via different basic mechanisms to ameliorate insulin resistance (IR) and elevated blood pressure (BP) associated with heavy sugar/starch consumption. Two dietary supplements (bea...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2013.770335
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that glucose ingestion leads to a decrease in plasma ionized calcium (iCa) and ionized magnesium (iMg) during the third trimester of pregnancy. METHODS:We studied 54 women who underwent a 50 g glucose challenge test (GCT) and 27 women who underwent a 3-hour 100 g glucose tolerance test...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1998.10718780
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to determine if dysprosium chloride (DyCl(3)) is a suitable nonabsorbable marker for studies of labeled-triglyceride excretion in cystic fibrosis patients allowing excretion to be determined accurately after analysis of one or two stools. METHODS:A series of 66 absorption studies wer...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2003.10719321
更新日期:2003-10-01 00:00:00
abstract::The misperception that dietary cholesterol determines blood cholesterol is held by many consumers in spite of evidence to the contrary. Many studies reported over the past 2 years have shown that dietary cholesterol is not a significant factor in an individual's plasma cholesterol level or cardiovascular disease (CVD)...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that causes great pain and disability and increasing oxidative stress in patients. The objective of the present study was to evaluate the effects of probiotics-live microorganisms with many health benefits, including antioxidant properties-on oxi...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2014.959208
更新日期:2016-05-01 00:00:00
abstract::Carbohydrate intolerance is positively correlated with saturated fat consumption. In contrast, individuals consuming diets comprised of polyunsaturated fatty acids (PUFA) have a lower incidence of diabetes mellitus (DM). To test the hypothesis that dietary fats may influence insulin sensitivity, insulin-stimulated glu...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1991.10718161
更新日期:1991-08-01 00:00:00
abstract::Abnormalities of the vascular endothelium contribute to all stages of atherosclerosis from lesion development to clinical cardiovascular disease events. Recognized risk factors, including diabetes mellitus, hypertension, dyslipidemia, cigarette smoking, and sedentary lifestyle are associated with endothelial dysfuncti...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2007.10719625
更新日期:2007-08-01 00:00:00
abstract::The impact of feeding a hypercaloric parenteral solution on N balance, energy metabolism, and muscle strength has been investigated in cachectic patients with gastrointestinal cancer and in malnourished patients without evidence of cancer (controls). Patients were examined during 5% dextrose administration (D5W) for 2...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1989.10720323
更新日期:1989-12-01 00:00:00
abstract::The 12-hr profiles of plasma glucose and insulin concentrations in 26 normal subjects ingesting a diet high in carbohydrate, protein, or fat have been determined. The diets were isocaloric and were given as three identical meals 4 hrs apart. In males the high carbohydrate diet resulted in glucose profiles similar to t...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1985.10720086
更新日期:1985-01-01 00:00:00