Effects of flavonoid-containing beverages and EGCG on endothelial function.

Abstract:

:Abnormalities of the vascular endothelium contribute to all stages of atherosclerosis from lesion development to clinical cardiovascular disease events. Recognized risk factors, including diabetes mellitus, hypertension, dyslipidemia, cigarette smoking, and sedentary lifestyle are associated with endothelial dysfunction. A variety of pharmacological and behavioral interventions have been shown to reverse endothelial dysfunction in patients with cardiovascular disease. A large number of epidemiological studies suggest that dietary factors, including increased intake of flavonoid-containing foods and beverages, reduce cardiovascular risk, and recent studies have shown that such beverages have favorable effects on endothelial function. These studies have engendered interest in the development of dietary supplements or drugs that would allow for more convenient and higher dose administration of flavonoids and might prove useful for prevention or treatment of cardiovascular disease. In this paper, we will review the contribution of endothelial dysfunction to the pathogenesis and clinical expression of atherosclerosis and recent data linking flavonoid and EGCG consumption to improved endothelial function and reduced cardiovascular risk.

journal_name

J Am Coll Nutr

authors

Shenouda SM,Vita JA

doi

10.1080/07315724.2007.10719625

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

366S-372S

issue

4

eissn

0731-5724

issn

1541-1087

pii

26/4/366S

journal_volume

26

pub_type

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