Abstract:
OBJECTIVE:In Sprague-Dawley rats (SD), we compared two categories of natural dietary supplements that influence carbohydrate (CHO) metabolism via different basic mechanisms to ameliorate insulin resistance (IR) and elevated blood pressure (BP) associated with heavy sugar/starch consumption. Two dietary supplements (bean extract and l-arabinose) are often referred to as carb blockers (CBs), because they slow the gastrointestinal absorption of CHO. Trivalent chromium (CR) falls into a group of so-called insulin sensitizers, because its major effect is to enhance peripheral insulin sensitivity. METHOD:We divided 48 mature male SD into 4 groups of 12. The first group received powdered baseline diet alone (Con). The remaining 3 SD groups (groups 2-4) ingested regular rat chow containing 20% w/w sucrose and 20% w/w rice starch. The second group received only this CHO-enriched chow. To the high-CHO diets of the remaining two groups, either CB to slow CHO absorption (CHO + CB) (group 3) or an insulin sensitizer, trivalent CR (CHO + CR; group 4), was added. RESULTS:Compared to Con group 1, adding high CHO content to the diet of group 2 significantly increased circulating glucose levels and systolic BP (SBP). Addition of CB or CR to the feed of groups 3 and 4 overcame the perturbations that occurred with high CHO challenge in group 2; that is, they lowered circulating glucose concentrations to Con levels, enhanced response to exogenous insulin, and overcame the gradual elevation of SBP. Compared to group 2, the two treatment groups (3 and 4) also showed decreased renin-angiotensin system activity, decreased serum angiotensin-converting enzyme activity, and enhanced nitric oxide activity. CONCLUSIONS:Our data indicate that high doses of CB and CR, despite their different mechanisms of action, can completely overcome CHO-induced IR and BP elevations. The data further suggest that CB and CR affect only the changes brought on by heavy CHO ingestion, because IR and SBP in groups 3 and 4 mirrored Con values (group 1), never producing values lower than baseline. Earlier use of CB and CR in the life cycle appears more effective in overcoming CHO-induced perturbations than later use.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Preuss HG,Echard B,Bagchi D,Perricone NVdoi
10.1080/07315724.2013.770335subject
Has Abstractpub_date
2013-01-01 00:00:00pages
58-65issue
1eissn
0731-5724issn
1541-1087journal_volume
32pub_type
杂志文章abstract::Exogenous, microbial beta-D-galactosidases are capable of effecting hydrolysis of lactose in situ in the gastrointestinal tract of lactase-deficient subjects when given as replacement therapy at mealtime. As its digestion products-glucose and galactose-are known to inhibit lactose hydrolysis in vitro, the effect of ad...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1986.10720131
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journal_title:Journal of the American College of Nutrition
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journal_title:Journal of the American College of Nutrition
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.1983.10719906
更新日期:1983-01-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2005.10719489
更新日期:2005-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of the American College of Nutrition
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更新日期:2016-01-01 00:00:00
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doi:10.1080/07315724.2013.875363
更新日期:2014-01-01 00:00:00
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doi:10.1080/07315724.2007.10719644
更新日期:2007-12-01 00:00:00
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doi:10.1080/07315724.2017.1396266
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,meta分析
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更新日期:2000-06-01 00:00:00
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journal_title:Journal of the American College of Nutrition
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doi:10.1080/07315724.2016.1269622
更新日期:2017-05-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章
doi:10.1080/07315724.2008.10719748
更新日期:2008-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
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更新日期:1997-08-01 00:00:00
abstract::Lutein and zeaxanthin are xanthophyll carotenoids found particularly in dark-green leafy vegetables and in egg yolks. They are widely distributed in tissues and are the principal carotenoids in the eye lens and macular region of the retina. Epidemiologic studies indicating an inverse relationship between xanthophyll i...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2004.10719427
更新日期:2004-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718586
更新日期:1996-04-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1992.10718265
更新日期:1992-12-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1416312
更新日期:2018-07-01 00:00:00
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journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2011.10719951
更新日期:2011-04-01 00:00:00