Abstract：
:Since there is evidence that fat distribution is a better predictor of cardiovascular disease than the degree of obesity, some risk factors for atherosclerosis have been evaluated in middle age Type II male diabetics and in obese subjects with and without glucose intolerance. In non-insulin-dependent diabetics (NIDD), abdominal obesity reflected by the waist/hip-circumference ratio (WHR) is related to parameters of metabolic control, lipid parameters, insulin status and response, hypertension, and vascular complications. High WHR is associated with: (a) significantly (p less than 0.01) higher HbA1 values than in the group without abdominal fat distribution; (b) a highly significant (p less than 0.001) negative correlation with high-density-lipoprotein cholesterol (HDL-C) and a positive correlation with the total/HDL-C ratio, which remains after correction for the body mass index; (c) higher apolipoprotein B concentrations; and (d) an elevated atherogenic index. Both fasting and postprandial insulin and C-peptide values may be a link between abdominal fat deposits and metabolic disturbances. Obese patients with upper body fat accumulation have significantly lower HDL-C levels, and a higher prevalence of glucose intolerance and diabetes than do patients with lower body fat obesity. Fasting glycemia, insulin, and the insulin area under the curve during an oral glucose load are significantly (p less than 0.005) increased in those with the greatest WHR, which is similar to that in NIDD and central obesity. An excess of abdominally located fat, even without manifest obesity, is associated with metabolic disturbances that indicate increased risk of atherogenesis and of higher morbidity and mortality, which may be due to characteristics of abdominally located adipocytes.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Van Gaal LF,Vansant GA,De Leeuw IHdoi
10.1080/07315724.1989.10720320subject
Has Abstractpub_date
1989-12-01 00:00:00pages
504-14issue
6eissn
0731-5724issn
1541-1087journal_volume
8pub_type
杂志文章,评审abstract：OBJECTIVE:Overfeeding with a high-fat and/or high-carbohydrate (CHO) diet is known to increase plasma concentrations of endotoxin (lipopolysaccharide [LPS]) that may lead to metabolic disturbances like insulin resistance. The impact of CHO quality (i.e., the glycemic index [GI]) independent of fat intake on metabolic e...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2016.1156036
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE AND METHODOLOGY:We determined the kinds and amounts of vitamin A compounds (retinol and various retinyl esters) circulating in serum and stored in liver and other selected tissues of ferrets, using high-performance liquid chromatography. RESULTS:The concentration of total retinyl esters in serum (43 +/- 1 mu...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.1994.10718376
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Postprandial hyperglycemia has been associated with increased oxidative stress and the development of diabetes, heart disease and all-cause mortality. OBJECTIVE:To assess the effect of novel maize-based dietary fibers on postprandial glycemia and to assess the correlation between a rapid in vitro digestibil...
journal_title：Journal of the American College of Nutrition
pub_type： 临床试验,杂志文章
doi：10.1080/07315724.2008.10719748
更新日期：2008-12-01 00:00:00
abstract：:The age at which children suffering from classical phenylketonuria can safely discontinue their dietary therapy has been constantly disputed over the past decades. Recently, most phenylketonuria centers have begun to recommend a life-long diet, especially for female patients. Male patients are also advised to continue...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.1994.10718402
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:Adequate dietary potassium intake is associated with a reduced risk of cardiovascular and other chronic diseases. The Dietary Guidelines for Americans 2005 identifies milk and milk products as a major contributor of dietary potassium and lists dairy products, along with fruits and vegetables, as food groups t...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2008.10719673
更新日期：2008-02-01 00:00:00
abstract：:Massive obesity results in serious diseases, which are a major public health problem. Surgery is frequently the only means to achieve and sustain significant weight loss. This historical overview is aimed at providing knowledge and appreciation of this surgery to scientists in other complex areas of nutrition. The dev...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.2013.797854
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:The sensitivity of one plasma and two urinary methods to assess zinc absorption after oral dosing were compared over the dose range of 10 to 100 mg. METHODS:Eleven healthy subjects participated in this four-way crossover design study. After an overnight fast, the subjects received a single oral dose of zinc...
journal_title：Journal of the American College of Nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/07315724.1996.10718568
更新日期：1996-02-01 00:00:00
abstract：:The lack of prevention of noncommunicable diseases (NCDs) has caused an increase in the mortality rate including conditions such as chronic kidney disease (CKD) and liver disease (LD). The high complexity of CKD and LD results in alterations in the metabolism of carbohydrates, proteins, and lipids. One of the changes ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2020.1810171
更新日期：2020-12-10 00:00:00
abstract：OBJECTIVE:Iron deficiency is the most common nutrient deficiency in the world. While deficiency can often be resolved through dietary supplementation with iron, adverse events are common and frequently preclude compliance. The objective of this study was to determine whether a food-derived dietary supplement containing...
journal_title：Journal of the American College of Nutrition
pub_type： 临床试验,杂志文章
doi：10.1080/07315724.2018.1427158
更新日期：2018-05-01 00:00:00
abstract：:Vitamin A deficiency is one of the most widespread nutritional deficiencies worldwide. Hundreds of millions of children and tens of millions of women living in Sub-Saharan Africa and Southeast Asia are at particularly high risk of the adverse health consequences associated with this largely preventable condition. Red ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.2010.10719845
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:Evidence from observational studies has suggested that carbohydrate quality rather than absolute intake is associated with greater risk of chronic diseases. The aim of this study was to examine the relationship between carbohydrate intake and dietary glycemic index and several cardiovascular disease risk fact...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2009.10719766
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2017.1302366
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Osteoporosis remains a major health problem in all developed countries and is a condition in which several dietary factors have been implicated. OBJECTIVE:To assess the nutritional status and levels of adiposity of postmenopausal women in relation to bone mineral density. DESIGN:A cross-sectional study in ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2013.866528
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The consequences of chronic, low grade lead (Pb) burden from earlier exposure on development of hypertension (HT) and cardiovascular disease is, at best, controversial, even though many epidemiological studies suggest the possibility. Accordingly, we examined ability of a short-term Pb challenge to cause late...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.1994.10718451
更新日期：1994-12-01 00:00:00
abstract：:To determine if the lower plasma ascorbic acid concentrations observed in males compared to females, and in the elderly in general, might be due to differences in renal clearances of ascorbic acid, tubular maximum reabsorptions (TmAA) and renal thresholds for ascorbic acid were determined on older (10 male, 10 female,...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.1993.10718349
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular fr...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2004.10719398
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVES:In adults, adaptation to changes in magnesium intake is largely due to changes in fractional magnesium absorption and urinary magnesium excretion. We sought to examine whether these homeostatic mechanism also occurred in young children. METHODS:Children, 12-48 m old were studied (n=30). They were adapted to...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2008.10719711
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:The following review of the literature on the importance of Selenium (Se) in myocardial homeostasis and of the pharmacology of this trace metal, represents an attempt to search, without prejudice to other possible explanations, for a rationale of a beneficial effect of Se substitution as an adjuvant to antiar...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.1994.10718441
更新日期：1994-10-01 00:00:00
abstract：:An inhibitor of folate metabolism, amethopterin (methotrexate) has been successfully used in the treatment of psoriasis and neoplastic disease. This drug produces several dangerous side effects of both an acute and chronic nature which have widely curtailed its use. A serious chronic side effect of the drug is its hep...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.1984.10720041
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVES:Indices of copper status, specifically serum copper and ceruloplasmin concentrations and erythrocyte superoxide dismutase activity, and iron status, including serum ferritin, transferrin receptors, hemoglobin and hematocrit, were studied in 27 college-aged females with adequate iron versus low iron stores. ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2002.10719253
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Baseline characteristics of subjects might be related to the effect of plant stanols on the serum lipoprotein profile. The aim of the study was to examine effects of subjects' baseline characteristics (baseline serum concentrations of lipids and lipoproteins at the start of the study, lathosterol, campesterol...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2008.10719683
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:This study was conducted to determine whether individuals attending an urban outpatient clinic met the National Health Promotion and Disease Prevention nutritional objectives and to assess factors associated with poor dietary habits. METHODS:Individuals who attended the general medicine outpatient clinic at ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.1995.10718488
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that plasma and urinary free choline concentrations decrease significantly during a marathon, and that these decreases may be associated with decreased performance. OBJECTIVE:In a pilot study, we sought to determine whether lecithin supplementation prior to a marathon would maint...
journal_title：Journal of the American College of Nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/07315724.2000.10718076
更新日期：2000-11-01 00:00:00
abstract：:Histidemia, first described by Ghadimi in 1961, is caused by a defect in histidase. The defect results in elevated urinary excretion of histidine and its transamination products, and in high blood histidine. Blood histidine levels in histidinemic patients range from 290 to 1420 microM (normal 70-120 microM). The clini...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.1993.10718291
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVE:Ingesting a mix of glucose and fructose during exercise increases exogenous carbohydrate oxidation while minimizing gastrointestinal (GI) distress. Several studies have suggested that a glucose-to-fructose ratio of 1.2:1 to 1:1 is optimal. No studies have quantified saccharides consumed during a nonsimulated ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2014.996830
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Diets containing beans have been associated with a lower risk of obesity and overweight in several dietary surveys. These results suggest a benefit might be derived from beans and other pulses, possibly due to improved satiety or satiation and therefore lowering energy intake. Such a hypothesis has not been ...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1080/07315724.2009.10719786
更新日期：2009-10-01 00:00:00
abstract：:Two-thirds of U.S. adults are overweight. There is an urgent need for effective methods for weight management. A potentially modifiable component of energy expenditure is the thermic effect of food (TEF), the increase in the metabolic rate that occurs after a meal. Evidence suggests that TEF is increased by larger mea...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章,评审
doi：10.1080/07315724.2018.1552544
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The aim of this work was to determine if dysprosium chloride (DyCl(3)) is a suitable nonabsorbable marker for studies of labeled-triglyceride excretion in cystic fibrosis patients allowing excretion to be determined accurately after analysis of one or two stools. METHODS:A series of 66 absorption studies wer...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2003.10719321
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment ce...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2008.10719731
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxic...
journal_title：Journal of the American College of Nutrition
pub_type： 杂志文章
doi：10.1080/07315724.2017.1409139
更新日期：2018-07-01 00:00:00
