Abstract:
:An inhibitor of folate metabolism, amethopterin (methotrexate) has been successfully used in the treatment of psoriasis and neoplastic disease. This drug produces several dangerous side effects of both an acute and chronic nature which have widely curtailed its use. A serious chronic side effect of the drug is its hepatotoxicity, which may culminate in hepatic cirrhosis and death. To date the underlying mechanism of methotrexate in producing liver damage is unknown. Results of three studies conducted in this laboratory on the nutritional effects of methotrexate offer some evidence that the hepatotoxicity may possibly be incurred through the effect of the drug on methionine biosynthesis and methylation processes. This thesis is discussed in the light of methylating agents vital to the synthesis of methionine.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Barak AJ,Tuma DJ,Beckenhauer HCdoi
10.1080/07315724.1984.10720041subject
Has Abstractpub_date
1984-01-01 00:00:00pages
93-6issue
1eissn
0731-5724issn
1541-1087journal_volume
3pub_type
杂志文章abstract:OBJECTIVE:The kinetics of magnesium (Mg) absorption, after drinking Magnesia mineral water (204 mg Mg/L), was investigated in healthy humans aged (23-60 yrs). METHODS:Serum Mg, calcium (Ca), potassium (K) and sodium (Na) content, blood hemoglobin, erythrocyte and white blood cell counts as well as urinary volume and u...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719424
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:The role of dietary glycemic index (GI) and glycemic load (GL) in the development of obesity has been debated globally. The relationship with body shape and fat distribution was examined in this cross-sectional association study among apparently healthy Iranian adults. METHODS AND MATERIALS:A study populatio...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1416312
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Osteoporosis remains a major health problem in all developed countries and is a condition in which several dietary factors have been implicated. OBJECTIVE:To assess the nutritional status and levels of adiposity of postmenopausal women in relation to bone mineral density. DESIGN:A cross-sectional study in ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2013.866528
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and i...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1347908
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:This study was designed to compare the metabolizable energy of two starch sources, standard cornstarch and high amylose cornstarch. METHODS:Diets containing 70% amylose (AM) or 70% amylopectin (AP) cornstarches were fed to 10 control and 14 hyperinsulinemic men for 14 weeks. During the last 4 weeks of each p...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718595
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:The consequences of chronic, low grade lead (Pb) burden from earlier exposure on development of hypertension (HT) and cardiovascular disease is, at best, controversial, even though many epidemiological studies suggest the possibility. Accordingly, we examined ability of a short-term Pb challenge to cause late...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1994.10718451
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:To estimate the association of anembryonic pregnancy with 55 elements, homocysteine, folate and S-adenosylhomocysteine in pregnant women. METHODS:Thirty cases of anembryonic pregnancy were diagnosed using ultrasound scanning that showed an empty gestation sac with no embryo pole in the uterus. Additionally, ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2009.10719761
更新日期:2009-02-01 00:00:00
abstract::Magnesium is unique among biological cations. Its volume change from hydrated cation to atomic ion is over an order of magnitude larger than that of any other biological cation. This volume change presents particular problems for a magnesium transport system and suggests that these systems may be significantly differe...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1994.10718431
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Micronutrients may influence the development and differentiation of sperm cells. The aim of this study was to assess the possible association of deficiencies in several vitamins and trace elements with sperm abnormalities in men with obesity. PARTICIPANTS AND METHODS:Thirty male patients with...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1387877
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:This study was designed to determine the composition of postprandial triglyceride-rich lipoproteins (TRL) after the intake of pomace olive oil (POO), which is a subproduct of the extraction of virgin olive oil (VOO) and presents a high concentration of minor components with biological activity. METHODS:Meals...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2007.10719582
更新日期:2007-02-01 00:00:00
abstract::Malnutrition has been often suggested as contributing to both the high incidence of hip fracture in elderly people and its complications. In a recent prospective controlled randomized study, the clinical outcome of elderly patients with osteoporotic fracture of the proximal femur (hip fracture) improved by giving a si...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1992.10718256
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:The objective of this study was to identify an association among dietary components, iron, and inflammatory status among adolescent girls. METHOD:Dietary information for 85 adolescent girls was collected through food frequency questionnaires. Biomarkers of iron and inflammatory status were analyzed. RESULT...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2018.1492470
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:This study was launched to determine comparative effects of corn oil (CO), safflower oil (SO), fish oil (FO) and palm oil (PO) on carnitine status and ethanol metabolism in rats. METHODS:Twenty-four male Sprague-Dawley rats (300 g bw) were randomly divided into four groups (n = 6) and fed a semisynthetic die...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2002.10719215
更新日期:2002-06-01 00:00:00
abstract::No single study or avenue of investigation can resolve the scientific controversies that entangle efforts to determine the effects of specific nutrients on medical conditions. To reach consensus in this area requires a substantial body of plausible, reproducible and consistent data from various investigative approache...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1999.10718904
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:Approximately 70% of all cancer patients have elevations in hepatic glucose production and/or reductions in glucose utilization. To identify an explanation for insulin resistance, we measured fasting hepatic glucose production (HGP), leucine appearance (Leu Ra), leucine oxidation (LO), glucose oxidation (GO) ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1995.10718519
更新日期:1995-08-01 00:00:00
abstract::Following massive small bowel resection, the remaining small bowel increases in mucosal weight, protein, deoxyribonucleic acid (DNA) content and absorptive function. Enteral nutrients are known to be important in stimulating this response. Recently, glutamine has been described as an essential fuel for the small intes...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that pectin, a source of dietary fiber that delays gastric emptying, increases satiety. METHODS:Male (n = 49) and female (n = 25) US Army employees within normal weight limits were fasted overnight then fed 448 mL of orange juice on 2 separate days followed 4 hours later by 0.473 L o...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1997.10718708
更新日期:1997-10-01 00:00:00
abstract::Associations among serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and levels of serum zinc (S-Zn), serum copper (S-Cu), and their ratio were analyzed in 3373 3-, 6-, 9-, 12-, 15-, and 18-year-old Finnish girls and boys. S-Zn was positively related to total cholesterol, HDL-choles...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1989.10720314
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:Replacing dietary refined carbohydrates (CHO) with protein may impact appetite and glucose and lipid metabolism in metabolically at-risk individuals. The objectives of this study were to assess the effects of consumption of a lean pork-containing, high-protein (pPro) breakfast versus a refined-CHO-rich breakf...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1396266
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Boron is an essential micronutrient for higher plants. The results of studies in animals and humans have suggested a potential role for boron as a modulator of the steroid hormone pathway. METHODS:As part of a study to obtain baseline information on boron in humans, the boron content of selected foods (66 i...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718638
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:Enteropathogenic Escherichia coli (EPEC) strains are able to adhere to human intestinal tissue inducing a typical lesion causing dissolution of the brush border membrane and loss of microvillus structure at sites of bacterial attachment. The presence of these lesions can provoke perpetuation of diarrhea assoc...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718586
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Intakes of ready-to-eat cereal (RTEC) have been inversely associated with risk factors of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes, and certain cancers; however, their relations with total and cause-specific mortality remain unclear. OBJECTIVE:To prospectively assess the associ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.971193
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The primary aim of this study was to assess the effects of dietary protein intake on energy restriction (ER)-induced changes in body mass and body composition. Clinical markers of metabolic and cardiovascular diseases were also measured. DESIGN:54 postmenopausal women, age 58 +/- 2 y, body mass index 29.6 +/...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2007.10719600
更新日期:2007-04-01 00:00:00
abstract::The old adage, "You are what you eat," is not always reliable, as demonstrated in this mixed-longitudinal study of men that began in 1969. Mean values of percent body fat, total body potassium (TBK), and total serum cholesterol (SCHOL) did not show changes that correlated with any studied nutrient from repeated 4-day ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1992.10718265
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:Our objective was to evaluate the effect of regular use of nutritional supplements on serum vitamin C levels in a multivariable regression model, taking into account other dietary and demographic variables which may affect nutritional status. METHODS:We analyzed NHANES II data for subjects age 3 to 74. Analy...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1994.10718367
更新日期:1994-02-01 00:00:00
abstract::Two-thirds of U.S. adults are overweight. There is an urgent need for effective methods for weight management. A potentially modifiable component of energy expenditure is the thermic effect of food (TEF), the increase in the metabolic rate that occurs after a meal. Evidence suggests that TEF is increased by larger mea...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.2018.1552544
更新日期:2019-08-01 00:00:00
abstract::Dietary intake surveys of rural and urban communities in three Pacific Island countries were conducted using an adjusted 24-hour dietary recall method. Dietary survey samples were drawn from noncommunicable disease surveys of Melanesians and Indians in Fiji, Micronesians in Kiribati and Melanesians in Vanuatu. Compari...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1992.10718229
更新日期:1992-06-01 00:00:00
abstract::The glycemic index (GI) was determined in 36 non-insulin-dependent diabetes mellitus patients who were fed 50 g carbohydrate portions of six Indian conventional foods, including rice, a combination of rice-legume (Bengalgram, peas, and greengram), and a combination of rice-dal (greengram dal and redgram dal -- dal is ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1990.10720411
更新日期:1990-12-01 00:00:00
abstract::Epidemiological studies indicate a strong relationship between dietary Mg intake and the incidence of sudden cardiac death. The mechanism by which dietary Mg leads to an increased incidence of cardiovascular disease is unknown but may involve alteration of electrolyte balance. In the present study, tissue electrolyte ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1985.10720074
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To evaluate several potential clinical indicators of magnesium status (diet, blood, urine, 24-hour load retention) in patients with congestive heart failure before, during, and after oral magnesium supplementation. METHODS:Twelve patients with New York Heart Association class II-III heart failure and 12 age ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1997.10718645
更新日期:1997-02-01 00:00:00