Effects of a diet rich in N-3 polyunsaturated fatty acids on systemic inflammation in renal transplant recipients.

Abstract:

OBJECTIVE:n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients. However, patient compliance is poor because bad-tasting fish oils are used as an n-3 PUFA source. Therefore, we explored whether the beneficial effects of n-3 can be obtained by administering a diet based on n-3-rich foods. METHODS:Sixty kidney transplant recipients were assigned to 2 different groups: the CON group (n = 28), which continued with their usual diet, and the DIET group (n = 32), which followed an n-3-rich diet for 6 months. Twenty-six patients in the DIET group and 24 in the CON group completed the study. End points of the study were changes in n-3 PUFAs intake, n-6:n-3 PUFAs ratio, systemic inflammation markers, and renal function during the 6 months of the dietary treatment. RESULTS:Three and 6 months after the beginning of the study, n-3 PUFA intake was significantly higher and the n-6:n-3 PUFA ratio was markedly lower than baseline in the DIET group. Plasma total cholesterol, triglycerides, C-reactive protein, and interleukin (IL)-6 decreased as well. IL-6 mRNA levels in peripheral blood mononuclear cells were also lower than at the beginning of the study. Proteinuria and microalbuminuria were reduced by 50% with respect to the baseline, whereas glomerular filtration rate (GFR) was unchanged. No change in the aforementioned parameters was observed in the CON group throughout the study. CONCLUSION:In long-term kidney transplant recipients a naturally n-3 PUFA-rich dietary plan causes an increase in n-3 PUFA intake, decreases systemic inflammation and proteinuria, and improves plasma lipid pattern.

journal_name

J Am Coll Nutr

authors

Sabbatini M,Apicella L,Cataldi M,Maresca I,Nastasi A,Vitale S,Memoli B,Postiglione L,Riccio E,Gallo R,Federico S,Guida B

doi

10.1080/07315724.2013.826482

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

375-83

issue

6

eissn

0731-5724

issn

1541-1087

journal_volume

32

pub_type

临床试验,杂志文章
  • Use of subjective global assessment to identify nutrition-associated complications and death in geriatric long-term care facility residents.

    abstract:OBJECTIVE:The primary objective of this study was to assess the use of Subjective Global Assessment to identify nutrition-associated complications and death in a geriatric population. A secondary objective was to evaluate the ability of Subjective Global Assessment to identify geriatric residents of long-term care faci...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2000.10718954

    authors: Sacks GS,Dearman K,Replogle WH,Cora VL,Meeks M,Canada T

    更新日期:2000-10-01 00:00:00

  • Strength changes induced by extreme dieting and exercise in severely obese females.

    abstract::Strength changes, induced by very low-calorie diet (VLCD, 520 kcal/day) alone and in combination with exercise, were determined in 109 severely obese females (46.8 +/- 4.69% fat). Experimental treatments included VLCD alone (LC, n = 40), VLCD with endurance exercise (EE, n = 23), VLCD with endurance exercise and resis...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:

    authors: Pronk NP,Donnelly JE,Pronk SJ

    更新日期:1992-04-01 00:00:00

  • Early lead challenge and subsequent hypertension in Sprague-Dawley rats.

    abstract:OBJECTIVE:The consequences of chronic, low grade lead (Pb) burden from earlier exposure on development of hypertension (HT) and cardiovascular disease is, at best, controversial, even though many epidemiological studies suggest the possibility. Accordingly, we examined ability of a short-term Pb challenge to cause late...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1994.10718451

    authors: Preuss HG,Jiang G,Jones JW,Macarthy PO,Andrews PM,Gondal JA

    更新日期:1994-12-01 00:00:00

  • Estrogenic effect of yam ingestion in healthy postmenopausal women.

    abstract:OBJECTIVE:Yam (Dioscorea) has been used to treat menopausal symptom folklorically. This study was to investigate the effects of yam ingestion on lipids, antioxidant status, and sex hormones in postmenopausal women. METHODS:Twenty-four apparently healthy postmenopausal women were recruited to replace their staple food ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1080/07315724.2005.10719470

    authors: Wu WH,Liu LY,Chung CJ,Jou HJ,Wang TA

    更新日期:2005-08-01 00:00:00

  • Efficacy of L-leucine Supplementation Coupled With Resistance Training in Untrained Midlife Women.

    abstract::Objective: This study investigated the effects of leucine supplementation with resistance training (RT) in untrained peri- and postmenopausal women on fat free mass, strength, and select anabolic-related hormones.Method: This was a randomized, double-blind, placebo-controlled trial, in which 36 untrained women were ra...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2019.1650675

    authors: Funderburk LK,Beretich KN,Chen MD,Willoughby DS

    更新日期:2020-05-01 00:00:00

  • Dairy in adulthood: from foods to nutrient interactions on bone and skeletal muscle health.

    abstract::The risk of fragility fractures exponentially increases with aging. Reduced mass and strength of both bone in osteoporosis and skeletal muscle in sarcopenia play a key role in the age-related incidence of fragility fractures. Undernutrition is often observed in the elderly, particularly in those subjects experiencing ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2013.816604

    authors: Bonjour JP,Kraenzlin M,Levasseur R,Warren M,Whiting S

    更新日期:2013-01-01 00:00:00

  • Serum Retinol, Folic Acid, and Copper Are Associated With Sperm Abnormalities in Men With Obesity.

    abstract:BACKGROUND AND OBJECTIVES:Micronutrients may influence the development and differentiation of sperm cells. The aim of this study was to assess the possible association of deficiencies in several vitamins and trace elements with sperm abnormalities in men with obesity. PARTICIPANTS AND METHODS:Thirty male patients with...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2017.1387877

    authors: Calderón B,Hevia V,Vega-Piñero B,Martín-Hidalgo A,Mendez-Del Sol H,Escobar-Morreale HF,Botella-Carretero JI

    更新日期:2018-03-01 00:00:00

  • Dietary intake and anthropometric status of 7 to 9 year old children in economically disadvantaged communities in Ontario.

    abstract:OBJECTIVE:There is limited information on the nutritional health of Canadian children, particularly those living in poverty. Our purpose was to assess the dietary and anthropometric status of economically disadvantaged children as part of the longitudinal, multidisciplinary prevention project, Better Beginnings, Better...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1995.10718548

    authors: Evers SE,Hooper MD

    更新日期:1995-12-01 00:00:00

  • Challenges of Administering Pancrelipase in Pancreatitis Patients.

    abstract:OBJECTIVE:This study evaluated nutrition status to determine the impact of a novel approach using elemental nutrition compared to pancrelipase administration in patients with pancreatitis. METHODS:This retrospective study included adult patients with pancreatitis who were nil per os (NPO) and received elemental nutrit...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2015.1052592

    authors: Antigua AD,Tran J,Lemon SJ,Zhang Y

    更新日期:2016-05-01 00:00:00

  • The effect of the digestion products of lactose (glucose and galactose) on its intraintestinal, in vivo hydrolysis by exogenous microbial beta-D-galactosidase.

    abstract::Exogenous, microbial beta-D-galactosidases are capable of effecting hydrolysis of lactose in situ in the gastrointestinal tract of lactase-deficient subjects when given as replacement therapy at mealtime. As its digestion products-glucose and galactose-are known to inhibit lactose hydrolysis in vitro, the effect of ad...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1986.10720131

    authors: Rosado JL,Deodhar AD,Bourges H,Solomons NW

    更新日期:1986-01-01 00:00:00

  • Is serum albumin a marker of malnutrition in chronic disease? The scleroderma paradigm.

    abstract:BACKGROUND:Malnutrition is common in many chronic diseases, but physicians may rely on a low albumin value before deciding that malnutrition is present. OBJECTIVE:To determine the relationship between serum albumin and malnutrition in systemic sclerosis (SSc) as a paradigm for other chronic diseases. DESIGN:Cross-sec...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1080/07315724.2010.10719828

    authors: Baron M,Hudson M,Steele R,Canadian Scleroderma Research Group (CSRG).

    更新日期:2010-04-01 00:00:00

  • Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection.

    abstract::Following massive small bowel resection, the remaining small bowel increases in mucosal weight, protein, deoxyribonucleic acid (DNA) content and absorptive function. Enteral nutrients are known to be important in stimulating this response. Recently, glutamine has been described as an essential fuel for the small intes...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:

    authors: Vanderhoof JA,Blackwood DJ,Mohammadpour H,Park JH

    更新日期:1992-04-01 00:00:00

  • Combined Administration of l-Carnitine and Ascorbic Acid Ameliorates Cisplatin-Induced Nephrotoxicity in Rats.

    abstract:OBJECTIVES:Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxic...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2017.1409139

    authors: Alabi QK,Akomolafe RO,Olukiran OS,Nafiu AO,Adefisayo MA,Owotomo OI,Omole JG,Olamilosoye KP

    更新日期:2018-07-01 00:00:00

  • A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats.

    abstract:OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular fr...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719398

    authors: Vink R,Donkin JJ,Cruz MI,Nimmo AJ,Cernak I

    更新日期:2004-10-01 00:00:00

  • Food safety evaluation of crops produced through biotechnology.

    abstract::Agricultural biotechnology has been widely adopted in agriculture but is also the focus of controversy. Questions have arisen regarding food and environmental safety. In the US, responsibility for ensuring agricultural and environmental safety is delegated to the USDA and EPA, respectively. The FDA has primary respons...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2002.10719261

    authors: Chassy BM

    更新日期:2002-06-01 00:00:00

  • Ecologic correlates of obesity in rural obese adults.

    abstract:OBJECTIVE:We examined relationships of individual and environmental factors with obesity and trying to lose weight in rural residents. METHODS:The joint contributions of individual and environmental factors on obesity status (obese vs. morbidly obese) and trying to lose weight (yes vs. no) were evaluated using general...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2007.10719632

    authors: Lee RE,Greiner KA,Hall S,Born W,Kimminau KS,Allison A,Ahluwalia JS

    更新日期:2007-10-01 00:00:00

  • Absorption and effect of the magnesium content of a mineral water in the human body.

    abstract:OBJECTIVE:The kinetics of magnesium (Mg) absorption, after drinking Magnesia mineral water (204 mg Mg/L), was investigated in healthy humans aged (23-60 yrs). METHODS:Serum Mg, calcium (Ca), potassium (K) and sodium (Na) content, blood hemoglobin, erythrocyte and white blood cell counts as well as urinary volume and u...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719424

    authors: Kiss SA,Forster T,Dongó A

    更新日期:2004-12-01 00:00:00

  • Eicosapentaenoic Acid-Rich Fish Oil Supplementation Inhibits the Decrease in Concentric Work Output and Muscle Swelling of the Elbow Flexors.

    abstract:OBJECTIVE:The aim of this study was to test the hypothesis that 8-week eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation improves peripheral muscle performance by concentric contractions (CONs) of elbow flexors in humans. METHODS:Sixteen healthy men were randomly administered with EPA and DHA ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2018.1470042

    authors: Ochi E,Yanagimoto K,Morishima T,Tsuchiya Y

    更新日期:2019-02-01 00:00:00

  • The body image, weight satisfaction, and eating disorder tendency of school children: the 2-year follow-up study.

    abstract:OBJECTIVE:This 2-year follow-up study was conducted to enhance our understanding of changes and rates of disturbed eating attitudes/behaviors, weight satisfaction, and prevalence of obesity in elementary school students between the ages of 10 and 12 years. METHODS:Questionnaires consisted of the following sections: (A...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2011.10719951

    authors: Wong Y,Chang YJ,Tsai MR,Liu TW,Lin W

    更新日期:2011-04-01 00:00:00

  • Nutrition and the patient requiring mechanical ventilatory support.

    abstract::Respiratory function in mechanically ventilated patients (VP) is adversely affected by starvation and hypermetabolic stress. These patients are more successfully managed and extubated if proper nutritional support is provided. The features of metabolism and respiratory function in VP require moderation in glucose, fat...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1983.10719906

    authors: Deitel M,Williams VP,Rice TW

    更新日期:1983-01-01 00:00:00

  • Diet-gene interactions in human lipoprotein metabolism.

    abstract::Genetic variation can influence the effects of hypocholesterolemic dietary interventions on lipoproteins involved in coronary artery disease (CAD). Individuals with the E4 allelic variant of the apo E gene exhibit greater low-density lipoprotein (LDL) cholesterol reductions on low-fat, low-cholesterol diets than subje...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.1997.10718692

    authors: Dreon DM,Krauss RM

    更新日期:1997-08-01 00:00:00

  • Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial.

    abstract:BACKGROUND:Foods that enhance satiety can help consumers to resist environmental cues to eat and help adherence to calorie restriction. The objective of this study was to compare the effect of 2 oat-based breakfast cereals on appetite, satiety, and food intake. METHODS:Forty-eight healthy individuals, 18 years of age ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2015.1032442

    authors: Rebello CJ,Johnson WD,Martin CK,Han H,Chu YF,Bordenave N,van Klinken BJ,O'Shea M,Greenway FL

    更新日期:2016-01-01 00:00:00

  • General and Central Adiposity in Older Adults in Palmas (TO): Prevalence and Associated Factors.

    abstract::Objectives: To evaluate the prevalence and associated factors with general and central adiposity in older adults in Palmas (TO).Methods: Cross-sectional study with older adults (≥60 years) of both sexes enrolled in the Family Health Strategy program in Palmas (TO). Sociodemographic aspects, health conditions, and func...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2020.1734989

    authors: Guimarães MSA,Santos KP,Castro JDS,Juvanhol LL,Rezende FAC,Ribeiro AQ

    更新日期:2020-11-01 00:00:00

  • Effects of l-Alanyl-l-Glutamine Ingestion on One-Hour Run Performance.

    abstract:OBJECTIVE:To examine the efficacy of l-alanyl-l-glutamine ingestion with a commercially available sports drink compared to the sports drink only on time to exhaustion and physiological measures during prolonged endurance exercise. METHODS:Twelve endurance-trained men (23.5 ± 3.7 years; 175.5 ± 5.4 cm; 70.7 ± 7.6 kg) p...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2015.1009193

    authors: McCormack WP,Hoffman JR,Pruna GJ,Jajtner AR,Townsend JR,Stout JR,Fragala MS,Fukuda DH

    更新日期:2015-01-01 00:00:00

  • Comparing effects of carbohydrate (CHO) blockers and trivalent chromium on CHO-induced insulin resistance and elevated blood pressure in rats.

    abstract:OBJECTIVE:In Sprague-Dawley rats (SD), we compared two categories of natural dietary supplements that influence carbohydrate (CHO) metabolism via different basic mechanisms to ameliorate insulin resistance (IR) and elevated blood pressure (BP) associated with heavy sugar/starch consumption. Two dietary supplements (bea...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2013.770335

    authors: Preuss HG,Echard B,Bagchi D,Perricone NV

    更新日期:2013-01-01 00:00:00

  • Association of calcium intake, dairy product consumption with overweight status in young adults (1995-1996): the Bogalusa Heart Study.

    abstract:OBJECTIVE:To examine the association between calcium intake and dairy product consumption with overweight and obesity in young adults. METHODS:The sample used in this study consisted of 1306 young adults, ages 19-38 years, who participated in the 1995-1996 young adult survey. Analysis was performed with analysis of co...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2006.10719568

    authors: Brooks BM,Rajeshwari R,Nicklas TA,Yang SJ,Berenson GS

    更新日期:2006-12-01 00:00:00

  • Absorbability and cost effectiveness in calcium supplementation.

    abstract:BACKGROUND:Cost-effectiveness of calcium supplementation depends not only on the cost of the product but on the efficiency of its absorption. Published cost-benefit analyses assume equal bioavailability for all calcium sources. Some published studies have suggested that there are differences in both the bioavailability...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/07315724.2001.10719038

    authors: Heaney RP,Dowell MS,Bierman J,Hale CA,Bendich A

    更新日期:2001-06-01 00:00:00

  • Effects of dietary magnesium on the development of hypertension in the spontaneously hypertensive rat.

    abstract::The effect of varying the amount of dietary magnesium on the development of hypertension in spontaneously hypertensive (SH) rats was investigated with three diets containing 1.05% (H1Mg diet), 0.52% (H2Mg diet), and 0.008% (LMg diet). The control group was given a diet containing a normal amount of magnesium (0.2%). W...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1983.10719931

    authors: Berthelot A,Esposito J

    更新日期:1983-01-01 00:00:00

  • Moving from efficacy to effectiveness: red palm oil's role in preventing vitamin A deficiency.

    abstract::Vitamin A deficiency is one of the most widespread nutritional deficiencies worldwide. Hundreds of millions of children and tens of millions of women living in Sub-Saharan Africa and Southeast Asia are at particularly high risk of the adverse health consequences associated with this largely preventable condition. Red ...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2010.10719845

    authors: Rice AL,Burns JB

    更新日期:2010-06-01 00:00:00

  • The glycemic index: physiological significance.

    abstract::The glycemic index (GI) is a physiological assessment of a food's carbohydrate content through its effect on postprandial blood glucose concentrations. Evidence from trials and observational studies suggests that this physiological classification may have relevance to those chronic Western diseases associated with ove...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

    doi:10.1080/07315724.2009.10718109

    authors: Esfahani A,Wong JM,Mirrahimi A,Srichaikul K,Jenkins DJ,Kendall CW

    更新日期:2009-08-01 00:00:00