Abstract：
BACKGROUND:Frequency domain Granger causality measures have been proposed and widely applied in analyzing rhythmic neurophysiological and biomedical signals. Almost all these measures are based on linear time domain regression models, and therefore can only detect linear causal effects in the frequency domain. NEW METHOD:A frequency domain causality measure, the partial directed coherence, is explicitly linked with the frequency response function concept of linear systems. By modeling the nonlinear relationships between time series using nonlinear models and employing corresponding frequency-domain analysis techniques (i.e., generalized frequency response functions), a new nonlinear partial directed coherence method is derived. RESULTS:The advantages of the new method are illustrated via a numerical example of a nonlinear physical system and an application to electroencephalogram signals from a patient with childhood absence epilepsy. COMPARISON WITH EXISTING METHODS:The new method detects both linear and nonlinear casual effects between bivariate signals in the frequency domain, while the existing measures can only detect linear effects. CONCLUSIONS:The proposed new method has important advantages over the classical linear measures, because detecting nonlinear dependencies has become more and more important in characterizing functional couplings in neuronal and biological systems.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
He F,Billings SA,Wei HL,Sarrigiannis PGdoi
10.1016/j.jneumeth.2014.01.013subject
Has Abstractpub_date
2014-03-30 00:00:00pages
71-80eissn
0165-0270issn
1872-678Xpii
S0165-0270(14)00024-7journal_volume
225pub_type
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