Abstract：
:The neocortex is the site of origin of several forms of acquired epilepsy. Here we provide a brief review of experimental models that were recently developed to study neocortical epileptogenesis as well as some major results obtained with these methods. Most of neocortical seizures appear to be nocturnal and it is known that neuronal activities reveal high levels of synchrony during slow-wave sleep. Therefore, we start the review with a description of mechanisms of neuronal synchronization and major forms of synchronized normal and pathological activities. Then, we describe three experimental models of seizures and epileptogenesis: ketamine-xylazine anesthesia as feline seizure triggered factor, cortical undercut as cortical penetrating wound model and neocortical kindling. Besides specific technical details describing these models we also provide major features of pathological brain activities recorded during epileptogenesis and seizures. The most common feature of all models of neocortical epileptogenesis is the increased duration of network silent states that up-regulates neuronal excitability and eventually leads to epilepsy.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Chauvette S,Soltani S,Seigneur J,Timofeev Idoi
10.1016/j.jneumeth.2015.08.030subject
Has Abstractpub_date
2016-02-15 00:00:00pages
185-201eissn
0165-0270issn
1872-678Xpii
S0165-0270(15)00321-0journal_volume
260pub_type
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