Establishment of leukemic T-cell lines from mice inoculated with the MAIDS defective virus.

abstract：:Crosslinking reagents were used to interrupt the process of filamentous phage morphogenesis and investigate the orientation in which nascent virions are extruded through the host cell membrane. Infected bacteria with emerging phage particles were crosslinked with glutaraldehyde. Immunoferritin-labeling studies on thes...

journal_title：Virology

authors： Lopez J,Webster RE

更新日期：1983-05-01 00:00:00

abstract：:Mixed infections of tobacco protoplasts with Cowpea chlorotic mottle virus (CCMV) and brome mosaic virus (BMV) have been studied. Fluorescent antibody staining showed that capsids of both viruses were made in doubly infected protoplasts but only infectious BMV could be recovered, i.e., BMV dominated in mixed infection...

journal_title：Virology

authors： Watts JW,Dawson JR

更新日期：1980-09-01 00:00:00

abstract：:Human Papillomavirus infection is highly prevalent worldwide. While most types of HPV cause benign warts, some high-risk types are known to cause cervical cancer, as well as cancer of the oral cavity and head and neck. Persistent cutaneous HPV infection can be particularly problematic in patients with chronic immunosu...

journal_title：Virology

authors： Devitt K,Hanson SJ,Tuong ZK,McMeniman E,Soyer HP,Frazer IH,Lukowski SW

更新日期：2019-11-01 00:00:00

abstract：:The human polyomavirus BK virus (BKV) is an important opportunistic pathogen whose disease prevalence continues to increase with the growing immunocompromised population. To date, the major determinant of replication in cell culture has not been formally proven. BKV exists as archetype virus and rearranged variants, w...

journal_title：Virology

authors： Broekema NM,Abend JR,Bennett SM,Butel JS,Vanchiere JA,Imperiale MJ

更新日期：2010-11-25 00:00:00

abstract：:Human embryo lung cells pretreated with a combination of human leukocyte interferon and acyclovir were infected with human cytomegalovirus (HCMV) and treated daily for 14 days with the same inhibitor combination. After removal of the inhibitors, the incubation temperature was maintained at either 37 or 40.5 degrees. I...

journal_title：Virology

authors： Bucher LJ,Wigdahl B,Rapp F

更新日期：1983-10-15 00:00:00

abstract：:We produced the putative protease 3C of human rhinovirus 1A (HRV-1A), a minor group rhinovirus, by Escherichia coli expression of a segment of HRV-1A cDNA coding for 3A, 3B, 3C, and parts of 2C and 3D (delta 2C3ABC delta 3D). The protease 3C was expected to be processed by intramolecular Q-G cleavages from the virus-s...

journal_title：Virology

authors： Aschauer B,Werner G,McCray J,Rosenwirth B,Bachmayer H

更新日期：1991-10-01 00:00:00

abstract：:Ts1, a temperature-sensitive mutant of Moloney murine leukemia virus-TB (MoMuLV-TB), causes a progressive hindlimb paralytic disease in susceptible strains of mice. Previously, it has been shown that a single amino acid substitution, Val-25----Ile in gPr80env, is responsible for the temperature sensitivity, inefficien...

journal_title：Virology

authors： Kamps CA,Lin YC,Wong PK

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2 is a novel coronavirus and the cause of COVID-19. More than 80% of COVID-19 patients exhibit mild or moderate symptoms. In this study, we investigated the dynamics of viral load and antibodies against SARS-CoV-2 in a longitudinal cohort of COVID-19 patients with severe and mild/moderate diseases. ...

journal_title：Virology

authors： Li L,Liang Y,Hu F,Yan H,Li Y,Xie Z,Huang L,Zhao J,Wan Z,Wang H,Shui J,Cai W,Tang S

更新日期：2020-12-01 00:00:00

abstract：:HIV-1 entry into cells requires the interaction of both HIV-1 envelope proteins and membrane lipids. We investigated the mechanism of neutralization of HIV-1 infection of primary monocyte-derived macrophages (MDM) by a murine monoclonal antibody (mAb) WR321. WR321 specifically binds phosphatidylinositol-4-phosphate an...

journal_title：Virology

authors： Jobe O,Peachman KK,Matyas GR,Asher LV,Alving CR,Rao M

更新日期：2012-09-01 00:00:00

abstract：:The 50-70 S RNA complex of a clone of Kirsten murine leukemia virus (Ki-MLV), propagated in NIH 3T3 cells, as well as that of a Moloney (Mo)-MLV, propagated in a mouse thymus-bone marrow cell line, contained an approximately 30 S RNA of unknown biological activity in addition to 38 S genomic RNA. The approximately 30 ...

journal_title：Virology

authors： Duesberg PH,Scolnick EM

更新日期：1977-11-01 00:00:00

abstract：:Cellular activation plays an important role in retroviral replication. Previously, we have shown that CD4(+)CD25(+) T cells by the virtue of their partially activated phenotype represent ideal candidates for a productive feline immunodeficiency virus (FIV) infection. In the present study, we extended our previous obse...

journal_title：Virology

authors： Joshi A,Garg H,Tompkins MB,Tompkins WA

更新日期：2005-05-10 00:00:00

abstract：:ICP27 is an essential herpes simplex virus type 1 (HSV-1) nuclear protein which regulates viral early and late genes during infection. The exact mechanism by which ICP27 modulates viral gene expression is unknown, but considerable evidence suggests that it functions posttranscriptionally. In this study, we have asked ...

journal_title：Virology

authors： Mears WE,Rice SA

更新日期：1998-03-01 00:00:00

abstract：:Currently, little is known about the ankyrin/F-box protein B4. Here, we report that B4R-null viruses exhibited reduced plaque size in tissue culture, and decreased ability to spread, as assessed by multiple-step growth analysis. Electron microscopy indicated that B4R-null viruses still formed mature and extracellular ...

journal_title：Virology

authors： Burles K,Irwin CR,Burton RL,Schriewer J,Evans DH,Buller RM,Barry M

更新日期：2014-05-01 00:00:00

abstract：:Two noncomplementing vaccinia virus temperature-sensitive mutants, Cts8 and Cts26, were mapped to the A3L gene, which encodes the major virion structural protein, 4b. The two ts mutants display normal patterns of gene expression, DNA replication, telomere resolution, and protein processing during infection. Morphogene...

journal_title：Virology

authors： Kato SE,Strahl AL,Moussatche N,Condit RC

更新日期：2004-12-05 00:00:00

abstract：:Molluscum contagiosum virus (MCV) is a human poxvirus that produces small, benign skin tumors primarily in young children and encodes proteins that modulate the host immune response. The MC51L, MC53L, and MC54L open reading frames of MCV have significant amino acid sequence similarities and related proteins are encode...

journal_title：Virology

authors： Xiang Y,Moss B

更新日期：1999-05-10 00:00:00

abstract：:We have investigated the interaction of SV40 virions with polarized monkey kidney epithelial cells. Virions were tagged with biotin to facilitate their detection and were found to retain full infectivity. When polarized Vero C1008 cells were incubated with biotinylated virions followed by a strepavidin-rhodamine conju...

journal_title：Virology

authors： Basak S,Turner H,Compans RW

更新日期：1992-09-01 00:00:00

abstract：:The infectivity in vivo, replication competence in vitro, and expression of viral genes of several molecularly cloned duck hepatitis B virus (DHBV) genomes were investigated. In addition, replication competence, core protein expression, and secretion of viral proteins were investigated for a grey heron hepatitis B vir...

journal_title：Virology

authors： Wildner G,Fernholz D,Sprengel R,Schneider R,Will H

更新日期：1991-11-01 00:00:00

abstract：:Genetic studies have been carried out on orbiviruses in the Great Island (GI) antigenic subgroup of the Kemerovo serogroup (Orbivrus, Reoviridae) to elucidate the functions of the 10 genomic double-stranded RNA segments. Such studies have shown that segment 4 is the major genetic determinant of neurovirulence (P.A. Nu...

journal_title：Virology

authors： Nuttall PA,Moss SR,Carey D,Jones LD,Jacobs SC

更新日期：1990-02-01 00:00:00

abstract：:An SH3-binding domain within the Nef protein of primate lentiviruses has been reported to be important to viral replication and infectivity and dispensable for CD4 downregulation, but its precise role remains unclear. This study investigates the effects of mutations in both the polyproline helix and in the hydrophobic...

journal_title：Virology

authors： Craig HM,Pandori MW,Riggs NL,Richman DD,Guatelli JC

更新日期：1999-09-15 00:00:00

abstract：:A natural variation is observed at position 4 of the 3'-end of influenza A virus genomes, where U (U4) or C (C4) is present. The replicon activity of C4 was 28% of U4. We compared the transcription and replication activity of U4 [v84(U4)], C4 [v84(C4)] and the complimentary RNA (c84) using the purified influenza virus...

journal_title：Virology

authors： Jiang H,Zhang S,Wang Q,Wang J,Geng L,Toyoda T

更新日期：2010-12-20 00:00:00

abstract：:Previous studies (Mertens et al., Virology 157, 375-386, 1987) have shown that removal of the outer capsid layer from bluetongue virus (BTV) significantly reduces (approximately x 10(-4)) the infectivity of the resultant core particle for mammalian cells (BHK 21 cells). In contrast, the studies reported here, using a ...

journal_title：Virology

authors： Mertens PP,Burroughs JN,Walton A,Wellby MP,Fu H,O'Hara RS,Brookes SM,Mellor PS

更新日期：1996-03-15 00:00:00

abstract：:We have previously described a selective increase in HIV-DNA content in CCR5-negative lymphocytes from late stage HIV-infected patients. Here, we show that this increase occurred even in the absence of viral phenotypic switching from CCR5- to CXCR4-tropic. This leads us to hypothesize that early and late CCR5-tropic v...

journal_title：Virology

authors： Pakarasang M,Wasi C,Suwanagool S,Chalermchockcharoenkit A,Auewarakul P

更新日期：2006-04-10 00:00:00

abstract：:The adenovirus E1A 243R oncoprotein encodes a potent transcription-repression function within the N-terminal 80 amino acids. Our proposed model of E1A repression predicts that E1A interacts with important cellular proteins on chromatin. Consistent with this idea, we report here that E1A proteins from in vivo formaldeh...

journal_title：Virology

authors： Green M,Panesar NK,Loewenstein PM

更新日期：2008-02-05 00:00:00

abstract：:Molecular piracy is a biological phenomenon in which one replicon (the pirate) uses the structural proteins encoded by another replicon (the helper) to package its own genome and thus allow its propagation and spread. Such piracy is dependent on a complex web of interactions between the helper and the pirate that occu...

journal_title：Virology

authors： Christie GE,Dokland T

更新日期：2012-12-20 00:00:00

abstract：:Chlorella viruses or chloroviruses form polysaccharide fibers on the cell wall of host Chlorella cells after infection. Such polysaccharides are either hyaluronan synthesized by virus-encoded hyaluronan synthase (HAS) or chitin synthesized by viral chitin synthase (CHS). Some chloroviruses synthesize both hyaluronan (...

journal_title：Virology

authors： Mohammed Ali AM,Kawasaki T,Yamada T

更新日期：2005-11-10 00:00:00

abstract：:In vitro, the coat protein of brome mosaic virus (BMV) inhibited RNA synthesis by replicase extracted from BMV-infected barley leaves. The inhibition was due to the interaction of coat protein with BMV RNA. Under the same conditions, no inhibition by TMV coat protein or bovine serum albumin was detected. For the compl...

journal_title：Virology

authors： Horikoshi M,Nakayama M,Yamaoka N,Furusawa I,Shishiyama J

更新日期：1987-05-01 00:00:00

abstract：:Although v-src, the oncogene of Rous sarcoma virus, has been shown to be capable of inducing lethal tumors at visceral sites distal to the primary tumor mass, the mechanisms opposing visceral tumor formation remain to be elucidated. In the present study, we show that visceral tumors, many of which represent a metastas...

journal_title：Virology

authors： Halpern MS,Wisner TW,Brown IP,England JM

更新日期：1993-11-01 00:00:00

abstract：:Ten mutations were introduced into the JC virus (JCV) T antigen within a region corresponding to the SV40 T-antigen DNA binding domain (SV40 amino acids 131 to 220); nine of these increased homology between the two proteins in sequences critical for SV40 T antigen DNA binding. All mutant JCV T antigens bound to JCV an...

journal_title：Virology

authors： Tavis JE,Frisque RJ

更新日期：1991-07-01 00:00:00

abstract：:The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...

journal_title：Virology

authors： Hick P,Gore K,Whittington R

更新日期：2013-02-05 00:00:00

abstract：:The nucleocapsid (N) protein genes of vesicular stomatitis virus, serotypes New Jersey and Indiana, were expressed in Escherichia coli BL21(DE3) transformed by the recombinant expression vector pET-3a containing N genes under the control of the T7 RNA polymerase promoter. Following induction with isopropylthiogalactop...

journal_title：Virology

authors： Das T,Banerjee AK

更新日期：1993-03-01 00:00:00