Abstract:
:Molecular piracy is a biological phenomenon in which one replicon (the pirate) uses the structural proteins encoded by another replicon (the helper) to package its own genome and thus allow its propagation and spread. Such piracy is dependent on a complex web of interactions between the helper and the pirate that occur at several levels, from transcriptional control to macromolecular assembly. The best characterized examples of molecular piracy are from the E. coli P2/P4 system and the S. aureus SaPI pathogenicity island/helper system. In both of these cases, the pirate element is mobilized and packaged into phage-like transducing particles assembled from proteins supplied by a helper phage that belongs to the Caudovirales order of viruses (tailed, dsDNA bacteriophages). In this review we will summarize and compare the processes that are involved in molecular piracy in these two systems.
journal_name
Virologyjournal_title
Virologyauthors
Christie GE,Dokland Tdoi
10.1016/j.virol.2012.10.028subject
Has Abstractpub_date
2012-12-20 00:00:00pages
210-21issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(12)00536-3journal_volume
434pub_type
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