Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast.

abstract：OBJECTIVE AND METHODS:The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS:A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic re...

journal_title：Annals of medicine

authors： Äijälä M,Ronkainen J,Huusko T,Malo E,Savolainen ER,Savolainen MJ,Salonurmi T,Bloigu R,Kesäniemi YA,Ukkola O

更新日期：2015-01-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00

abstract：:Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...

journal_title：Annals of medicine

authors： Riekkinen P Jr,Schmidt BH,van der Staay FJ

更新日期：1998-12-01 00:00:00

abstract：:Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

journal_title：Annals of medicine

authors： Koren G

更新日期：2004-01-01 00:00:00

abstract：:Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pat...

journal_title：Annals of medicine

authors： Jeffery CJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national ...

journal_title：Annals of medicine

authors： Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated. METHODS:A total ...

journal_title：Annals of medicine

authors： Ahola AJ,Thorn LM,Saraheimo M,Forsblom C,Groop PH,Finndiane Study Group.

更新日期：2010-10-01 00:00:00

abstract：:Atrial fibrillation is a common cardiac arrhythmia with rapid and irregular atrial activity. Instead of uniformly contracting as one chamber, the atrial compartment fibrillates. Several studies have demonstrated that this arrhythmia contributes substantially to cardiac morbidity and mortality. The purpose of this revi...

journal_title：Annals of medicine

authors： Miyazaki S,Shah AJ,Scherr D,Haïssaguerre M

更新日期：2011-01-01 00:00:00

abstract：:Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine...

journal_title：Annals of medicine

authors： Nammas W,Koistinen J,Paana T,Karjalainen PP

更新日期：2017-08-01 00:00:00

abstract：:Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

journal_title：Annals of medicine

authors： Lönnberg H,Vuorio E

更新日期：1996-12-01 00:00:00

abstract：:The circadian rhythms of night shift workers do not usually adjust to their unusual work and sleep schedules, reducing their quality of life and producing potentially dangerous health and safety problems. This paper reviews field studies of simulated night work in which shifted light-dark cycles were constructed with ...

journal_title：Annals of medicine

authors： Eastman CI,Martin SK

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：:In the Netherlands there are about 9700 explicit requests for euthanasia or physician-assisted suicide (EAS) each year, of which approximately 3600 are granted. Other countries have criticized the Dutch policy concerning EAS. It has been suggested that palliative care in the Netherlands is not adequate and that euthan...

journal_title：Annals of medicine

authors： Swarte NB,Heintz AP

更新日期：1999-12-01 00:00:00

abstract：:Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...

journal_title：Annals of medicine

authors： Maassen JA,Janssen GM,'t Hart LM

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...

journal_title：Annals of medicine

authors： Shivalkar B,Goovaerts I,Salgado RA,Ozsarlak O,Bosmans J,Parizel PM,Vrints CJ

更新日期：2007-01-01 00:00:00

abstract：:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocre...

journal_title：Annals of medicine

authors： Tafti M,Maret S,Dauvilliers Y

更新日期：2005-01-01 00:00:00

abstract：:The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment stra...

journal_title：Annals of medicine

authors： Gaede P,Pedersen O

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

journal_title：Annals of medicine

authors： Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

更新日期：2017-05-01 00:00:00

abstract：:Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...

journal_title：Annals of medicine

authors： Rivera R

更新日期：1993-02-01 00:00:00

abstract：:This is a brief overview of the cytokine network within juvenile chronic arthritis, introducing the concept of the production of T-helper 1 (TH-1) or TH2-cell differentiation as a result of cytokine production, as well as the concept of the balance between pro- and anti-inflammatory cytokines. The balance of TH1 and T...

journal_title：Annals of medicine

authors： Woo P

更新日期：1997-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

journal_title：Annals of medicine

authors： Ali R,Cusi K

更新日期：2009-01-01 00:00:00

abstract：:On average, 15,000 cases of measles occurred annually in Finland before the initiation of a vaccination programme in 1975. Because of insufficient activity, the vaccination coverage failed to reach the required level of over 90%, and cases continued to occur. The policy was revolutionized in 1982 by launching a projec...

journal_title：Annals of medicine

authors： Heinonen OP,Paunio M,Peltola H

更新日期：1998-04-01 00:00:00

abstract：:The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

journal_title：Annals of medicine

authors： Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

更新日期：1991-10-01 00:00:00

abstract：:In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de...

journal_title：Annals of medicine

authors： Kirjavainen PV,Gibson GR

更新日期：1999-08-01 00:00:00

abstract：:Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...

journal_title：Annals of medicine

authors： Huikuri HV

更新日期：1997-08-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of idiopathic interstitial pneumonia. The disease, which occurs primarily in middle-aged and older adults, is thought to arise following an aberrant reparative response to alveolar epithelial cell injury characterized by secretion of excessive amou...

journal_title：Annals of medicine

authors： Spagnolo P,Sverzellati N,Rossi G,Cavazza A,Tzouvelekis A,Crestani B,Vancheri C

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...

journal_title：Annals of medicine

authors： Baldassarre D,De Jong A,Amato M,Werba JP,Castelnuovo S,Frigerio B,Veglia F,Tremoli E,Sirtori CR

更新日期：2008-01-01 00:00:00

abstract：:Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic aut...

journal_title：Annals of medicine

authors： Bespalova IN,Buxbaum JD

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...

journal_title：Annals of medicine

authors： González Silva Y,Abad Manteca L,de la Red Gallego H,Álvarez Muñoz M,Rodríguez Carbajo M,Murcia Casado T,Ausín Pérez L,Abadía Otero J,Pérez-Castrillón JL

更新日期：2018-09-01 00:00:00