Animal models in the development of symptomatic and preventive drug therapies for Alzheimer's disease.

abstract：:Steroids diffuse through polysiloxone at a constant rate, and steroids placed in the vagina rapidly pass through the vaginal epithelium into the circulation. Combining these principles led to the development of contraceptive vaginal rings (CVR) consisting of various progestins, with and without oestrogen, placed in fl...

journal_title：Annals of medicine

authors： Mishell DR Jr

更新日期：1993-04-01 00:00:00

abstract：:The metabolic syndrome, which is very common in the general population, is defined by the clustering of several classic cardiovascular risk factors, such as type 2 diabetes, hypertension, high triglycerides and low high-density lipoprotein cholesterol (HDL). Central obesity and insulin resistance, which are the two un...

journal_title：Annals of medicine

authors： Bonora E

更新日期：2006-01-01 00:00:00

abstract：:A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...

journal_title：Annals of medicine

authors： Wald NJ,Kennard A,Smith D

更新日期：1994-02-01 00:00:00

abstract：:Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...

journal_title：Annals of medicine

authors： Heikinheimo O,Kekkonen R

更新日期：1993-02-01 00:00:00

abstract：:Clinical know-how and skills as well as up-to-date scientific evidence are cornerstones for providing effective treatment for patients. However, in order to improve the effectiveness of treatment in ordinary practice, also appropriate documentation of care at the health care units and benchmarking based on this docume...

journal_title：Annals of medicine

authors： Malmivaara A

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated. METHODS:A total ...

journal_title：Annals of medicine

authors： Ahola AJ,Thorn LM,Saraheimo M,Forsblom C,Groop PH,Finndiane Study Group.

更新日期：2010-10-01 00:00:00

abstract：:During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

journal_title：Annals of medicine

authors： Borch K

更新日期：1989-08-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in sper...

journal_title：Annals of medicine

authors： Tapanainen JS,Aittomäki K,Huhtaniemi IT

更新日期：1997-08-01 00:00:00

abstract：:Hereditary tyrosinaemia type I is the most common of the diseases caused by defects in tyrosine metabolism. The underlying genetic defect is a mutation in the gene for fumarylacetate hydrolase (FAH), and more than 30 different mutations in this gene have been identified. The main clinical consequences of this defect i...

journal_title：Annals of medicine

authors： Pitkänen ST,Salo MK,Heikinheimo M

更新日期：2000-11-01 00:00:00

abstract：:It is established beyond doubt that free radicals in tissues and cells can damage DNA, proteins, carbohydrates and lipids. These potentially deleterious reactions are at least partly controlled by antioxidants capable of scavenging free radicals. It is widely believed that a proper balance between free radicals and an...

journal_title：Annals of medicine

authors： Rautalahti M,Huttunen J

更新日期：1994-12-01 00:00:00

abstract：:Inflammatory diseases are on the rise in westernized countries, but also in urbanized areas of developing countries. A number of studies have now demonstrated a negative association between helminth infections and inflammatory diseases, such as allergy, suggesting a potential role for helminth-induced immune responses...

journal_title：Annals of medicine

authors： Smits HH,Yazdanbakhsh M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...

journal_title：Annals of medicine

authors： Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JP

更新日期：2009-01-01 00:00:00

abstract：IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...

journal_title：Annals of medicine

authors： Mamza J,Mehta R,Donnelly R,Idris I

更新日期：2016-01-01 00:00:00

abstract：:A new form of acute hepatic porphyria with double genetic defect--deficiency of porphobilinogen deaminase and coproporphyrinogen oxidase--is described. Among 17 studied family members this double enzymatic deficiency was found in five individuals, deficiency of porphobilinogen deaminase in four, and deficiency of copr...

journal_title：Annals of medicine

authors： Gregor A,Kostrzewska E,Tarczynska-Nosal S,Stachurska H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS:We searched databases to identify randomized trials with controlled human exposures to ...

journal_title：Annals of medicine

authors： Vieira JL,Macedo FY,Benjo AM,Guimarães GV,Contreras JP,Bocchi EA

更新日期：2017-03-01 00:00:00

abstract：:Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting w...

journal_title：Annals of medicine

authors： Rueda-Camino JA,Losada-Vila B,De Ancos-Aracil CL,Rodríguez-Lajusticia L,Tardío JC,Zapatero-Gaviria A

更新日期：2016-01-01 00:00:00

abstract：:The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...

journal_title：Annals of medicine

authors： Lehtimäki L,Turjanmaa V,Kankaanranta H,Saarelainen S,Hahtola P,Moilanen E

更新日期：2000-09-01 00:00:00

abstract：:High-dose chemotherapy followed by transplantation of autologous hematopoietic progenitor cells has a proven track record of safety and efficacy in hematological malignancies and select solid tumors. The near-universal use of peripheral blood stem cells as source for autografts, routine growth factor support, and anti...

journal_title：Annals of medicine

authors： Hamadani M

更新日期：2014-12-01 00:00:00

abstract：:Leukocyte adhesion to endothelium is essential for the development of an appropriate immune-inflammatory response. The vital importance of leukocyte-endothelial adhesive interactions in host defense and homeostasis is illustrated by the clinical manifestations of patients with congenital defects of leukocyte adhesion ...

journal_title：Annals of medicine

authors： Repo H,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:Thymoma is an unusual tumour, but it is the most common malignancy in the anterior mediastinum. This tumour is unique in its frequent association with paraneoplastic syndrome and its potential for indolent growth. The distinction between thymomas and other tumours which arise in the anterior or superior mediastinum is...

journal_title：Annals of medicine

authors： Loehrer PJ Sr

更新日期：1999-10-01 00:00:00

abstract：:After the sequencing of the human genome has been completed, non-invasive imaging studies are needed to assess the function of new genes in living organisms. The evaluation of genetically manipulated animals or new designed biomolecules will require a thorough understanding of physiology, biochemistry and pharmacology...

journal_title：Annals of medicine

authors： Haberkorn U,Altmann A

更新日期：2003-01-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00

abstract：:The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

journal_title：Annals of medicine

authors： Casadevall A,Pirofski LA

更新日期：2002-01-01 00:00:00

abstract：:Congruence of evidence from all medical research methodologies has established the major causal influences in cardiovascular disease. Causation thus established, epidemiological observations are the best available evidence on which to base estimates of the potential of preventive strategies. From population comparison...

journal_title：Annals of medicine

authors： Blackburn H

更新日期：1989-06-01 00:00:00

abstract：:INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow...

journal_title：Annals of medicine

authors： Donnez J,Silber S,Andersen CY,Demeestere I,Piver P,Meirow D,Pellicer A,Dolmans MM

更新日期：2011-01-01 00:00:00

abstract：:Naltrexone is the first safe and effective pharmaceutical adjunct for use in the treatment of alcohol abuse. Theoretically it could be effective also as a means for terminating methadone maintenance and in the treatment of other forms of substance abuse. Two general types of protocols have been used with naltrexone. O...

journal_title：Annals of medicine

authors： Sinclair JD

更新日期：1998-08-01 00:00:00

abstract：:More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...

journal_title：Annals of medicine

authors： Kaluza GL,Ali NM,Raizner AE

更新日期：2000-12-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocre...

journal_title：Annals of medicine

authors： Tafti M,Maret S,Dauvilliers Y

更新日期：2005-01-01 00:00:00