Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births.

abstract：:Regenerative medicine is a multidisciplinary field utilizing the potential of stem cells and the regenerative capability of the body to restore, maintain, or enhance tissue and organ functions. Stem cells are unspecialized cells that can self-renew but also differentiate into several somatic cells when subjected the a...

journal_title：Annals of medicine

authors： Kaivosoja E,Barreto G,Levón K,Virtanen S,Ainola M,Konttinen YT

更新日期：2012-11-01 00:00:00

abstract：:Cardiac arrhythmias cause more than 300,000 sudden deaths each year in the USA alone. Long QT syndrome (LQT) is a cardiac disorder that causes sudden death from ventricular tachyarrhythmias, specifically torsade de pointes. Four LQT genes have been identified: KVLQT1 (LQT1) on chromosome 11p15.5, HERG (LQT2) on chromo...

journal_title：Annals of medicine

authors： Wang Q,Chen Q,Towbin JA

更新日期：1998-02-01 00:00:00

abstract：:Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...

journal_title：Annals of medicine

authors： Almasy L

更新日期：2003-01-01 00:00:00

abstract：:Study of the growth and development of cartilage and bone has been difficult because the structure of the tissues makes biological experiments hard to conduct. Recent advances in molecular biology have offered new possibilities for studying these processes. Many cartilage and bone specific cDNAs have been cloned and c...

journal_title：Annals of medicine

authors： Sandberg MM

更新日期：1991-08-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban,...

journal_title：Annals of medicine

authors： Li YG,Pastori D,Lip GYH

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:The circadian clock generates oscillations in physiology and behavior, known as circadian rhythms. Links between the circadian clock genes Periods, Bmal1, and Cryptochromes and aging and cancer are emerging. Circadian clock gene expression is changed in human pathologies, and transgenic mice with mutations in clock ge...

journal_title：Annals of medicine

authors： Khapre RV,Samsa WE,Kondratov RV

更新日期：2010-09-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：:Autoantibodies directed to intracellular antigens can be detected in many systemic rheumatic diseases. In this review, we discuss the clinical significance of antinuclear antibodies (ANA) associated with systemic lupus erythematosus (SLE), Slögren's syndrome, scleroderma and polymyositis/dermatomyositis, the immunogen...

journal_title：Annals of medicine

authors： Hietarinta M,Lassila O

更新日期：1996-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...

journal_title：Annals of medicine

authors： Griffin BE,Xue SA

更新日期：1998-06-01 00:00:00

abstract：:Atrial fibrillation is a common cardiac arrhythmia with rapid and irregular atrial activity. Instead of uniformly contracting as one chamber, the atrial compartment fibrillates. Several studies have demonstrated that this arrhythmia contributes substantially to cardiac morbidity and mortality. The purpose of this revi...

journal_title：Annals of medicine

authors： Miyazaki S,Shah AJ,Scherr D,Haïssaguerre M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:This meta-analysis aimed to compare the treatment of an acute asthma attack in children in the emergency department (ED) with inhaled corticosteroids (ICS) versus placebo or oral systemic corticosteroids (SC) as assessed by the hospital admission rates. METHODS:After searching Medline, Cochrane, EMBASE, and...

journal_title：Annals of medicine

authors： Su XM,Yu N,Kong LF,Kang J

更新日期：2014-02-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic con...

journal_title：Annals of medicine

authors： Vetter V,Denizer G,Friedland LR,Krishnan J,Shapiro M

更新日期：2018-03-01 00:00:00

abstract：:The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

journal_title：Annals of medicine

authors： Casadevall A,Pirofski LA

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the ...

journal_title：Annals of medicine

authors： Halverson T,Alagiakrishnan K

更新日期：2020-12-01 00:00:00

abstract：:Leukocyte adhesion to endothelium is essential for the development of an appropriate immune-inflammatory response. The vital importance of leukocyte-endothelial adhesive interactions in host defense and homeostasis is illustrated by the clinical manifestations of patients with congenital defects of leukocyte adhesion ...

journal_title：Annals of medicine

authors： Repo H,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:The question why low-density lipoprotein (LDL) stranded in the subendothelium of arteries should acquire the proinflammatory properties that initiate and sustain atherogenesis has puzzled researchers for decades. The most popular concept contends that oxidative processes are crucial because oxidized LDL (ox-LDL) produ...

journal_title：Annals of medicine

authors： Bhakdi S

更新日期：1998-12-01 00:00:00

abstract：:We evaluated the reliability hospital discharge register data in the assessment of acute myocardial infarction trends. In the FINMONICA study areas, trends in age standarized attack rates for the years 1983-90 were calculated independently from two sources: the nationwide Finnish hospital discharge register and the FI...

journal_title：Annals of medicine

authors： Mähönen M,Miettinen H,Pyörälä K,Molarius A,Salomaa V,Kuulasmaa K

更新日期：1995-10-01 00:00:00

abstract：:Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...

journal_title：Annals of medicine

authors： Tuohy VK,Jaini R

更新日期：2011-08-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：:A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...

journal_title：Annals of medicine

authors： Wald NJ,Kennard A,Smith D

更新日期：1994-02-01 00:00:00

abstract：:The recent identification of mutations in the RET proto-oncogene that are associated with multiple endocrine neoplasia type 2 (MEN 2) syndromes has allowed therapeutic intervention in affected individuals on the basis of direct genetic testing. The principal endocrine neoplasm that occurs in patients with the MEN 2 sy...

journal_title：Annals of medicine

authors： Lairmore TC,Frisella MM,Wells SA Jr

更新日期：1996-10-01 00:00:00

abstract：:Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...

journal_title：Annals of medicine

authors： Després JP

更新日期：2001-11-01 00:00:00

abstract：:Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...

journal_title：Annals of medicine

authors： Huch R,Huch A

更新日期：1993-06-01 00:00:00

abstract：:Cardiac rhythm during sleep was analysed in 168 healthy men aged 19 to 30 (mean 21.8) years using continuous nocturnal ECG recordings. Thirty five of the subjects were endurance athletes; 99 were recorded at home and 69 at a garrison during military service. The number of short term (less than one min) accelerations o...

journal_title：Annals of medicine

authors： Viitasalo M,Halonen L,Partinen M,Iivanainen M,Kala R,Eisalo A

更新日期：1991-04-01 00:00:00

abstract：:It is established beyond doubt that free radicals in tissues and cells can damage DNA, proteins, carbohydrates and lipids. These potentially deleterious reactions are at least partly controlled by antioxidants capable of scavenging free radicals. It is widely believed that a proper balance between free radicals and an...

journal_title：Annals of medicine

authors： Rautalahti M,Huttunen J

更新日期：1994-12-01 00:00:00

abstract：IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...

journal_title：Annals of medicine

authors： Mamza J,Mehta R,Donnelly R,Idris I

更新日期：2016-01-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in sarcomeric proteins. It is characterized by left ventricular hypertrophy in the absence of an increased external load, and myofibrillar disarray. While hypertrophy is a common cardiac response to injury, disarray is the pathologi...

journal_title：Annals of medicine

authors： Marian AJ,Roberts R

更新日期：1998-08-01 00:00:00