Clinical significance of antinuclear antibodies in systemic rheumatic diseases.

abstract：BACKGROUND:Commercial nucleic acid amplification tests, designed for the detection of Mycobacterium tuberculosis DNA/RNA in respiratory samples, are often applied also in nonrespiratory specimens in order to verify the diagnosis of extrapulmonary tuberculosis. AIM. To evaluate the value of the Abbott LCx Mycobacterium ...

journal_title：Annals of medicine

authors： Rantakokko-Jalava K,Marjamäki M,Marttila H,Mäkelä L,Valtonen V,Viljanen MK

更新日期：2001-02-01 00:00:00

abstract：:Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mec...

journal_title：Annals of medicine

authors： Krishnamoorthy S,Lim SH,Lip GY

更新日期：2009-01-01 00:00:00

abstract：:Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...

journal_title：Annals of medicine

authors： Hovatta I,Barlow C

更新日期：2008-01-01 00:00:00

abstract：:The understanding and treatment of schizophrenia have been greatly hampered by uncertainty about etiological factors and controversy about diagnostic boundaries. Adoption studies have helped clarify both of these problems. First, the adoptees study method, the index offspring of adopting-away schizophrenic biological ...

journal_title：Annals of medicine

authors： Tienari PJ,Wynne LC

更新日期：1994-08-01 00:00:00

abstract：INTRODUCTION:The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. MATERIALS AND METHODS:Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded...

journal_title：Annals of medicine

authors： Kang SH,Jung DJ,Choi EW,Park JW,Cho KH,Yoon KW,Do JY

更新日期：2015-01-01 00:00:00

abstract：:The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been increasing for the last four decades. In this review determinants for an increased IgE synthesis are discussed on both an epidemiological and on an immunological level with special emphasis on the differentiation of the B cell to an IgE-produ...

journal_title：Annals of medicine

authors： Poulsen LK,Hummelshoj L

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...

journal_title：Annals of medicine

authors： Shivalkar B,Goovaerts I,Salgado RA,Ozsarlak O,Bosmans J,Parizel PM,Vrints CJ

更新日期：2007-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of idiopathic interstitial pneumonia. The disease, which occurs primarily in middle-aged and older adults, is thought to arise following an aberrant reparative response to alveolar epithelial cell injury characterized by secretion of excessive amou...

journal_title：Annals of medicine

authors： Spagnolo P,Sverzellati N,Rossi G,Cavazza A,Tzouvelekis A,Crestani B,Vancheri C

更新日期：2015-02-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

journal_title：Annals of medicine

authors： Jafar-Mohammadi B,McCarthy MI

更新日期：2008-01-01 00:00:00

abstract：:Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...

journal_title：Annals of medicine

authors： Miettinen OS,Caro JJ

更新日期：1989-10-01 00:00:00

abstract：:Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...

journal_title：Annals of medicine

authors： Riekkinen P Jr,Schmidt BH,van der Staay FJ

更新日期：1998-12-01 00:00:00

abstract：:The majority of patients with low back pain offer no objective clinical findings on which to make a diagnosis on the basis of physical examination. Therefore a diagnostic categorization of complaint based on duration and location is proposed. The justification for this organization is the assumption that the majority ...

journal_title：Annals of medicine

authors： Mooney V

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

journal_title：Annals of medicine

authors： Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

更新日期：2009-01-01 00:00:00

abstract：:Immunocytochemical studies using antibodies to cytoskeletal proteins have provided conflicting data on the components of paired helical filaments (PHF), due solely to immunological cross-reactivities. To avoid such ambiguity, we developed a protein chemical approach to the identification of the PHF components. After t...

journal_title：Annals of medicine

authors： Ihara Y,Kondo J

更新日期：1989-01-01 00:00:00

abstract：:Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...

journal_title：Annals of medicine

authors： Huch R,Huch A

更新日期：1993-06-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...

journal_title：Annals of medicine

authors： Raitakari OT,Celermajer DS

更新日期：2000-07-01 00:00:00

abstract：:Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART- (highly-active antiretroviral therapy)-associated lipodystrophy. Both obese and lipodystrophic patients, however, have an increase in the amo...

journal_title：Annals of medicine

authors： Yki-Järvinen H

更新日期：2005-01-01 00:00:00

abstract：:Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...

journal_title：Annals of medicine

authors： van Hagen PM,Hofland LJ,ten Bokum AM,Lichtenauer-Kaligis EG,Kwekkeboom DJ,Ferone D,Lamberts SW

更新日期：1999-10-01 00:00:00

abstract：:In the last three decades the incidence of metabolic syndrome (MetS) has been growing worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). In children and adolescents such epidemics are particularly worrisome, since the metabolic consequences in adulthoo...

journal_title：Annals of medicine

authors： Alisi A,Cianfarani S,Manco M,Agostoni C,Nobili V

更新日期：2012-02-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's d...

journal_title：Annals of medicine

authors： Ingelsson M,Hyman BT

更新日期：2002-01-01 00:00:00

abstract：:Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic con...

journal_title：Annals of medicine

authors： Vetter V,Denizer G,Friedland LR,Krishnan J,Shapiro M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00

abstract：IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...

journal_title：Annals of medicine

authors： Mamza J,Mehta R,Donnelly R,Idris I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...

journal_title：Annals of medicine

authors： Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JP

更新日期：2009-01-01 00:00:00

abstract：:Molecular oxygen (O2)is a basic requirement for cellular growth and viability and many aspects of anatomy and physiology are dedicated to achieving reliable distribution. Recent work has identified a specific sensing and response system, centred around a transcription complex called Hypoxia-inducible Factor 1 (HIF-1),...

journal_title：Annals of medicine

authors： Wiesener MS,Maxwell PH

更新日期：2003-01-01 00:00:00

abstract：:The circadian rhythms of night shift workers do not usually adjust to their unusual work and sleep schedules, reducing their quality of life and producing potentially dangerous health and safety problems. This paper reviews field studies of simulated night work in which shifted light-dark cycles were constructed with ...

journal_title：Annals of medicine

authors： Eastman CI,Martin SK

更新日期：1999-04-01 00:00:00