Genetic testing and early thyroidectomy for inherited medullary thyroid carcinoma.

Abstract:

:The recent identification of mutations in the RET proto-oncogene that are associated with multiple endocrine neoplasia type 2 (MEN 2) syndromes has allowed therapeutic intervention in affected individuals on the basis of direct genetic testing. The principal endocrine neoplasm that occurs in patients with the MEN 2 syndromes is medullary thyroid carcinoma. This thyroid neoplasm is the only consistently malignant feature of the MEN 2 syndromes and it is the most common cause of death in affected patients. Kindred members at risk for one of the MEN 2 syndromes can be studied by direct DNA analysis to determine whether they have inherited a RET mutation. Those with a positive test can be treated by early thyroidectomy and cured when the disease is microscopic and localized to the thyroid gland. Total thyroidectomy is performed as early as 5 years of age and is associated with minimal morbidity and virtually no mortality. Residual or persistent medullary thyroid carcinoma following thyroidectomy can best be determined by detecting increased levels of calcitonin following the administration of intravenous calcium gluconate and pentagastrin.

journal_name

Ann Med

journal_title

Annals of medicine

authors

Lairmore TC,Frisella MM,Wells SA Jr

doi

10.3109/07853899608999099

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

401-6

issue

5

eissn

0785-3890

issn

1365-2060

journal_volume

28

pub_type

杂志文章,评审
  • Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study.

    abstract:AIM:Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined. METHODS:We ...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2018.1523549

    authors: Jin JL,Sun D,Cao YX,Guo YL,Wu NQ,Zhu CG,Gao Y,Dong QT,Zhang HW,Liu G,Dong Q,Li JJ

    更新日期:2018-11-01 00:00:00

  • Protein C pathway in sepsis.

    abstract::The goals of this chapter are to provide a brief review of the biology of the protein C pathway and some of the features of the pathway that make it uniquely positioned to control microvascular coagulation and control the acute inflammatory response. Activated protein C works as an antithrombotic agent by inactivating...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/078538902321117823

    authors: Esmon CT

    更新日期:2002-01-01 00:00:00

  • DQA1 and DQB1 heterodimers in insulin-dependent diabetes mellitus: a genetic-epidemiological study in Finland. DiMe Study Group.

    abstract::Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899209167007

    authors: Tuomilehto-Wolf E,Tuomilehto J,Hitman GA

    更新日期:1992-12-01 00:00:00

  • Drug development for neurodegenerative diseases: role of PET.

    abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899908998803

    authors: Rinne JO

    更新日期:1999-12-01 00:00:00

  • LCx Mycobacterium tuberculosis assay is valuable with respiratory specimens, but provides little help in the diagnosis of extrapulmonary tuberculosis.

    abstract:BACKGROUND:Commercial nucleic acid amplification tests, designed for the detection of Mycobacterium tuberculosis DNA/RNA in respiratory samples, are often applied also in nonrespiratory specimens in order to verify the diagnosis of extrapulmonary tuberculosis. AIM. To evaluate the value of the Abbott LCx Mycobacterium ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,多中心研究

    doi:10.3109/07853890109002060

    authors: Rantakokko-Jalava K,Marjamäki M,Marttila H,Mäkelä L,Valtonen V,Viljanen MK

    更新日期:2001-02-01 00:00:00

  • Autoinflammatory diseases and cardiovascular manifestations.

    abstract::Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by m...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2010.547212

    authors: Rigante D,Cantarini L,Imazio M,Lucherini OM,Sacco E,Galeazzi M,Brizi MG,Brucato A

    更新日期:2011-08-01 00:00:00

  • What is a pathogen?

    abstract::The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

    journal_title:Annals of medicine

    pub_type: 社论

    doi:10.1080/078538902317338580

    authors: Casadevall A,Pirofski LA

    更新日期:2002-01-01 00:00:00

  • Current approaches to the treatment of thymoma.

    abstract::Thymoma is an unusual tumour, but it is the most common malignancy in the anterior mediastinum. This tumour is unique in its frequent association with paraneoplastic syndrome and its potential for indolent growth. The distinction between thymomas and other tumours which arise in the anterior or superior mediastinum is...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Loehrer PJ Sr

    更新日期:1999-10-01 00:00:00

  • Course of mixed connective tissue disease in children.

    abstract::Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-te...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899708999362

    authors: Michels H

    更新日期:1997-10-01 00:00:00

  • Mesenchymal stem cells.

    abstract::About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to differentiate under defined in vitro conditions into multiple cell types present in many different tissues, e.g. osteoblasts, chondroblasts...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890500371957

    authors: Väänänen HK

    更新日期:2005-01-01 00:00:00

  • Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS).

    abstract:INTRODUCTION:Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS:A total of 2003 individuals from the Helsinki Birth C...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890.2015.1004360

    authors: Eriksson JG,Sandboge S,Salonen M,Kajantie E,Osmond C

    更新日期:2015-03-01 00:00:00

  • Diagnosis and treatment of vulvodynia.

    abstract::Vulvodynia is a complex multifactorial and multidisciplinary clinical syndrome of unexplained vulvar pain, sexual dysfunction, and psychological disability. Because of the absence of abnormal physical findings among such patients, vulvodynia was long thought to be solely a psychosomatic syndrome. The incidence or prev...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899509031955

    authors: Paavonen J

    更新日期:1995-04-01 00:00:00

  • Progression of venous pathology after pacemaker and cardioverter-defibrillator implantation: A prospective serial venographic study.

    abstract:BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802498961

    authors: Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

    更新日期:2009-01-01 00:00:00

  • Molecular basis for apo A-IV polymorphisms.

    abstract::Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899209147839

    authors: Tenkanen H,Ehnholm C

    更新日期:1992-10-01 00:00:00

  • Adjuvant hormone therapy in breast cancer.

    abstract::Recent results from controlled trials of adjuvant tamoxifen and oophorectomy in early breast cancer are reviewed. The results of the statistical overview performed by the Early Breast Cancer Trialists Collaborative Group are summarised, and some important questions left open by this overview are discussed. These inclu...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析

    doi:10.3109/07853899209148333

    authors: Blomqvist CP,Elomaa I,Rissanen P

    更新日期:1992-04-01 00:00:00

  • Chemokines and atherosclerosis.

    abstract::Atherosclerosis is an inflammatory disease of the vessel wall, characterized by the accumulation of leukocytes, especially macrophages and T-cells. Chemokines are small heparin-binding polypeptides, whose main function is to attract cells to the areas of developing inflammation. They function by ligating G-protein cou...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890310019961

    authors: Sheikine Y,Hansson GK

    更新日期:2004-01-01 00:00:00

  • Mucosal immunity and viral infections.

    abstract::The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890109002074

    authors: Freihorst J,Ogra PL

    更新日期:2001-04-01 00:00:00

  • Sequence analysis of the genes encoding for H+/K+-ATPase in autoimmune gastritis.

    abstract:BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890600673260

    authors: Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

    更新日期:2006-01-01 00:00:00

  • Inherited disorders of blood coagulation.

    abstract::Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2011.576698

    authors: Lippi G,Franchini M,Montagnana M,Favaloro EJ

    更新日期:2012-08-01 00:00:00

  • Population strategies of cardiovascular disease prevention: scientific base, rationale and public health implications.

    abstract::Congruence of evidence from all medical research methodologies has established the major causal influences in cardiovascular disease. Causation thus established, epidemiological observations are the best available evidence on which to base estimates of the potential of preventive strategies. From population comparison...

    journal_title:Annals of medicine

    pub_type: 临床试验,杂志文章,评审

    doi:10.3109/07853898909149926

    authors: Blackburn H

    更新日期:1989-06-01 00:00:00

  • Next generation sequencing applications for cardiovascular disease.

    abstract::The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; th...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890.2017.1392595

    authors: Kalayinia S,Goodarzynejad H,Maleki M,Mahdieh N

    更新日期:2018-03-01 00:00:00

  • Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

    abstract:PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析

    doi:10.1080/07853890.2018.1500703

    authors: Kunutsor SK,Seidu S,Khunti K

    更新日期:2018-09-01 00:00:00

  • Increased bronchial nitric oxide production in patients with asthma measured with a novel method of different exhalation flow rates.

    abstract::The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890008995949

    authors: Lehtimäki L,Turjanmaa V,Kankaanranta H,Saarelainen S,Hahtola P,Moilanen E

    更新日期:2000-09-01 00:00:00

  • Medical research on a complaint: orientation and priorities.

    abstract::Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149228

    authors: Miettinen OS,Caro JJ

    更新日期:1989-10-01 00:00:00

  • Thoracic endovascular aortic repair versus open chest surgical repair for patients with type B aortic dissection: a systematic review and meta-analysis.

    abstract::Aim: This meta-analysis study aimed to compare the efficacy and safety of TEVAR versus OCSR for TBAD patients.Methods: We systematically searched PubMed, EmBase, and the Cochrane library to identify studies compared the effectiveness of TEVAR and OCSR in TBAD patients from the inception up to July 2019. The summary re...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析

    doi:10.1080/07853890.2019.1679874

    authors: Liu J,Xia J,Yan G,Zhang Y,Ge J,Cao L

    更新日期:2019-01-01 00:00:00

  • Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast.

    abstract::There is increasing evidence that fasting hypertriglyceridaemia identifies individuals who are at increased risk for coronary artery disease. It is probable that this reflects the effects of the smaller triglyceride-bearing lipoproteins. It may also reflect increased levels of postprandial lipoproteins. There is consi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899309147307

    authors: Steiner G

    更新日期:1993-10-01 00:00:00

  • Visceral pain: mechanisms of peripheral and central sensitization.

    abstract::This paper describes the responses of peripheral and central visceral nociceptive systems to acute injury and discusses these observations in relation to the concept of 'pre-emptive analgesia'. Visceral nociceptors are known to respond to injury but are also known to become sensitized to non-noxious stimuli during the...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899509031965

    authors: Cervero F

    更新日期:1995-04-01 00:00:00

  • Genomic imprinting: concept and clinical consequences.

    abstract::One of the major discoveries in modern genetics is the phenomenon of genomic, or parental, imprinting. The parent-of-origin effects seen after transmission of an imprinted gene from parents to their children do not follow the genetic rules postulated by Gregor Mendel. This has obvious consequences for genetic counsell...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899909019258

    authors: Mannens M,Alders M

    更新日期:1999-02-01 00:00:00

  • Are 12-lead ECG findings associated with the risk of cardiovascular events after ischemic stroke in young adults?

    abstract:INTRODUCTION:Ischemic stroke (IS) in a young patient is a disaster and recurrent cardiovascular events could add further impairment. Identifying patients with high risk of such events is therefore important. The prognostic relevance of ECG for this population is unknown. MATERIALS AND METHODS:A total of 690 IS patient...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2016.1202443

    authors: Pirinen J,Putaala J,Aarnio K,Aro AL,Sinisalo J,Kaste M,Haapaniemi E,Tatlisumak T,Lehto M

    更新日期:2016-11-01 00:00:00

  • Elevated serum ICTP concentrations reflect poor prognosis in patients with ovarian carcinoma.

    abstract::The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899509031937

    authors: Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

    更新日期:1995-02-01 00:00:00