Epstein-Barr virus infections and their association with human malignancies: some key questions.

abstract：:The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile acids, determined by a genetic predisposition interacting with environmental factors. The total amount of oestrogens and progesterone circulating in the blood or...

journal_title：Annals of medicine

authors： Reyes H,Sjövall J

更新日期：2000-03-01 00:00:00

abstract：:Hypertension is a major cardiovascular risk factor with a multifactorial pathogenesis, including genetic and environmental factors. In addition to hypothesis-driven strategies, unbiased approaches such as genomics, proteomics, and metabolomics are useful tools to help unravel the pathophysiology of hypertension and as...

journal_title：Annals of medicine

authors： Delles C,Neisius U,Carty DM

更新日期：2012-06-01 00:00:00

abstract：:Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...

journal_title：Annals of medicine

authors： Miettinen OS,Caro JJ

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national ...

journal_title：Annals of medicine

authors： Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula S

更新日期：2015-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

journal_title：Annals of medicine

authors： Ali R,Cusi K

更新日期：2009-01-01 00:00:00

abstract：:Although food habits arc not stable and unchanging during a person's lifetime, a base for healthy food habits can be created in early childhood. Children's food habits can be assumed to be influenced by their parents' food habits and choices. The aim of this article is to review factors influencing food choice in chil...

journal_title：Annals of medicine

authors： Hursti UK

更新日期：1999-01-01 00:00:00

abstract：:Epidemiological and experimental studies indicate an inverse relationship between the risk of colon cancer development and intake of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). All NSAIDs are known inhibitors of cyclo-oxygenase, the enzyme responsible for converting arachidonic acid to prostagland...

journal_title：Annals of medicine

authors： Gustafson-Svärd C,Lilja I,Hallböök O,Sjödahl R

更新日期：1997-06-01 00:00:00

abstract：:Troglitazone is a novel once-daily oral antidiabetic agent for the treatment of type 2 diabetes patients. Here, we report the overall dose response characteristics of troglitazone, with respect to effects on metabolic control, using a pharmacodynamic model. Data from week 12 from two previously reported double-blind, ...

journal_title：Annals of medicine

authors： Young MA,Eckland DJ,Eastmond R,Lettis S

更新日期：1998-04-01 00:00:00

abstract：IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...

journal_title：Annals of medicine

authors： Mamza J,Mehta R,Donnelly R,Idris I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:Diabetes in childhood and adolescence is a difficult, lifelong, evolving disorder. Insulin treatment is essential for the establishment and maintenance of optimal metabolic control but it is only part of a comprehensive child-focused management strategy which must be initiated at the time of diagnosis. Attention must ...

journal_title：Annals of medicine

authors： Swift PG

更新日期：1997-10-01 00:00:00

abstract：:Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...

journal_title：Annals of medicine

authors： Riekkinen P Jr,Schmidt BH,van der Staay FJ

更新日期：1998-12-01 00:00:00

abstract：:Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's d...

journal_title：Annals of medicine

authors： Ingelsson M,Hyman BT

更新日期：2002-01-01 00:00:00

abstract：:The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...

journal_title：Annals of medicine

authors： Freihorst J,Ogra PL

更新日期：2001-04-01 00:00:00

abstract：AIM:Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined. METHODS:We ...

journal_title：Annals of medicine

authors： Jin JL,Sun D,Cao YX,Guo YL,Wu NQ,Zhu CG,Gao Y,Dong QT,Zhang HW,Liu G,Dong Q,Li JJ

更新日期：2018-11-01 00:00:00

abstract：:More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...

journal_title：Annals of medicine

authors： Kaluza GL,Ali NM,Raizner AE

更新日期：2000-12-01 00:00:00

abstract：:Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

journal_title：Annals of medicine

authors： Aho K,Heliövaara M

更新日期：2004-01-01 00:00:00

abstract：:Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...

journal_title：Annals of medicine

authors： Tenkanen H,Ehnholm C

更新日期：1992-10-01 00:00:00

abstract：INTRODUCTION:Inflammation is an important contributor to the development of chronic diseases. We examined whether a healthy Nordic diet, also called the Baltic Sea diet, associates with lower concentrations of inflammatory markers. METHODS:We used two independent cross-sectional studies: the DILGOM study including Fin...

journal_title：Annals of medicine

authors： Kanerva N,Loo BM,Eriksson JG,Leiviskä J,Kaartinen NE,Jula A,Männistö S

更新日期：2014-03-01 00:00:00

abstract：:The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...

journal_title：Annals of medicine

authors： Roine R,Humaloja K,Hämäläinen J,Nykänen I,Ylikahri R,Salaspuro M

更新日期：1989-02-01 00:00:00

abstract：:Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-te...

journal_title：Annals of medicine

authors： Michels H

更新日期：1997-10-01 00:00:00

abstract：INTRODUCTION:We studied prevalence of hypovitaminosis D, its determinants, and whether achievement of recommended dietary vitamin D intake (10 μg/d) is associated with absence of hypovitaminosis D in adults. METHODS:The study is part of the Cardiovascular Risk in Young Finns Study. We collected serum samples of 25-hyd...

journal_title：Annals of medicine

authors： Voipio AJ,Pahkala KA,Viikari JS,Mikkilä V,Magnussen CG,Hutri-Kähönen N,Kähönen M,Lehtimäki T,Männistö S,Loo BM,Jula A,Marniemi J,Juonala M,Raitakari OT

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AIMS:A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ke...

journal_title：Annals of medicine

authors： Takaike H,Uchigata Y,Iwamoto Y,Imagawa A,Iwahashi H,Kanatsuka A,Kawasaki E,Kobayashi T,Shimada A,Shimizu I,Maruyama T,Hanafusa T,Makino H

更新日期：2008-01-01 00:00:00

abstract：:Thymoma is an unusual tumour, but it is the most common malignancy in the anterior mediastinum. This tumour is unique in its frequent association with paraneoplastic syndrome and its potential for indolent growth. The distinction between thymomas and other tumours which arise in the anterior or superior mediastinum is...

journal_title：Annals of medicine

authors： Loehrer PJ Sr

更新日期：1999-10-01 00:00:00

abstract：:Circadian rhythms are a cardinal feature of living organisms. The stereotypical organization of homeostatic, endocrine and behavioural variables around the 24-hour cycle constitutes one of the most conserved attributes among species. It is now well established that circadian rhythmicity is not a learned behaviour, but...

journal_title：Annals of medicine

authors： Florez JC,Takahashi JS

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and wheth...

journal_title：Annals of medicine

authors： Liuba P,Aburawi EH,Pesonen E,Andersson S,Truedsson L,Ylä-Herttuala S,Holmberg L

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the ...

journal_title：Annals of medicine

authors： Halverson T,Alagiakrishnan K

更新日期：2020-12-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...

journal_title：Annals of medicine

authors： Mäkikallio T,Jalava MP,Husso A,Virtanen M,Laakso T,Ahvenvaara T,Tauriainen T,Maaranen P,Kinnunen EM,Dahlbacka S,Jaakkola J,Airaksinen J,Anttila V,Savontaus M,Laine M,Juvonen T,Valtola A,Raivio P,Eskola M,Niemelä M,

更新日期：2019-01-01 00:00:00

abstract：:Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pat...

journal_title：Annals of medicine

authors： Jeffery CJ

更新日期：2003-01-01 00:00:00