Mucosal immunity and viral infections.

Abstract:

:The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced cytokines, such as type 1 interferons and natural killer (NK) cell activity, while specific immune responses mainly depend on cytotoxic T cells, which are important especially in the early course of a viral infection, and on antibodies. At the mucosal sites, antiviral secretory IgA antibodies play a major role in clearing viral infections and preventing or modifying disease after re-exposure. Passive transfer of virus-specific antibodies has been used in experimental and clinical settings to prevent or treat viral mucosal infections. In the future, the development of new mucosal vaccines promises to have the strongest impact on the epidemiology of viral infections.

journal_name

Ann Med

journal_title

Annals of medicine

authors

Freihorst J,Ogra PL

doi

10.3109/07853890109002074

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

172-7

issue

3

eissn

0785-3890

issn

1365-2060

journal_volume

33

pub_type

杂志文章,评审
  • Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit?

    abstract::Pulmonary arterial hypertension is a rapidly progressing disease characterized by an over- expression of endothelin. In addition to its potent pulmonary vasoconstrictor effects, endothelin has been shown to produce many of the aberrant changes, such as hypertrophy, fibrosis, inflammation, and neurohormonal activation ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890310017477

    authors: Clozel M

    更新日期:2003-01-01 00:00:00

  • Systemic effects of controlled exposure to diesel exhaust: a meta-analysis from randomized controlled trials.

    abstract:INTRODUCTION:Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS:We searched databases to identify randomized trials with controlled human exposures to ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析

    doi:10.1080/07853890.2016.1252054

    authors: Vieira JL,Macedo FY,Benjo AM,Guimarães GV,Contreras JP,Bocchi EA

    更新日期:2017-03-01 00:00:00

  • Chemokines and atherosclerosis.

    abstract::Atherosclerosis is an inflammatory disease of the vessel wall, characterized by the accumulation of leukocytes, especially macrophages and T-cells. Chemokines are small heparin-binding polypeptides, whose main function is to attract cells to the areas of developing inflammation. They function by ligating G-protein cou...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890310019961

    authors: Sheikine Y,Hansson GK

    更新日期:2004-01-01 00:00:00

  • Progression of venous pathology after pacemaker and cardioverter-defibrillator implantation: A prospective serial venographic study.

    abstract:BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802498961

    authors: Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

    更新日期:2009-01-01 00:00:00

  • ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study.

    abstract:BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802649738

    authors: Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

    更新日期:2009-01-01 00:00:00

  • Neuropeptides and their receptors in the immune system.

    abstract::Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:

    authors: van Hagen PM,Hofland LJ,ten Bokum AM,Lichtenauer-Kaligis EG,Kwekkeboom DJ,Ferone D,Lamberts SW

    更新日期:1999-10-01 00:00:00

  • The effectiveness of teriparatide in the clinical practice--attenuation of the bone mineral density outcome by increasing age and bisphosphonate pretreatment.

    abstract:BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890.2012.742560

    authors: Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

    更新日期:2013-05-01 00:00:00

  • Functional genomics and radioisotope-based imaging procedures.

    abstract::After the sequencing of the human genome has been completed, non-invasive imaging studies are needed to assess the function of new genes in living organisms. The evaluation of genetically manipulated animals or new designed biomolecules will require a thorough understanding of physiology, biochemistry and pharmacology...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890310006479

    authors: Haberkorn U,Altmann A

    更新日期:2003-01-01 00:00:00

  • Association between low-grade albuminuria and hearing impairment in a non-diabetic Korean population: The Korea National Health and Nutrition Examination Survey (2011-2013).

    abstract:INTRODUCTION:The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. MATERIALS AND METHODS:Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890.2015.1093163

    authors: Kang SH,Jung DJ,Choi EW,Park JW,Cho KH,Yoon KW,Do JY

    更新日期:2015-01-01 00:00:00

  • Ultrasonography of the lower uterine segment after multiple caesarean sections.

    abstract::Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899009147256

    authors: Kirkinen P

    更新日期:1990-04-01 00:00:00

  • Detection of Helicobacter pylori infection: when to perform which test?

    abstract::This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890109002063

    authors: Braden B,Caspary WF

    更新日期:2001-03-01 00:00:00

  • MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?

    abstract::MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their le...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2014.958196

    authors: Tay HL,Plank M,Collison A,Mattes J,Kumar RK,Foster PS

    更新日期:2014-12-01 00:00:00

  • Diagnosis and treatment of vulvodynia.

    abstract::Vulvodynia is a complex multifactorial and multidisciplinary clinical syndrome of unexplained vulvar pain, sexual dysfunction, and psychological disability. Because of the absence of abnormal physical findings among such patients, vulvodynia was long thought to be solely a psychosomatic syndrome. The incidence or prev...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899509031955

    authors: Paavonen J

    更新日期:1995-04-01 00:00:00

  • Atrophic gastritis and gastric carcinoid tumours.

    abstract::During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149210

    authors: Borch K

    更新日期:1989-08-01 00:00:00

  • Significant increases in urinary dolichol levels in bacterial infections, malignancies and pregnancy but not in other clinical conditions.

    abstract::The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149176

    authors: Roine R,Humaloja K,Hämäläinen J,Nykänen I,Ylikahri R,Salaspuro M

    更新日期:1989-02-01 00:00:00

  • New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD).

    abstract::Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890802552437

    authors: Ali R,Cusi K

    更新日期:2009-01-01 00:00:00

  • Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice.

    abstract::Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/17431380410032643

    authors: Koren G

    更新日期:2004-01-01 00:00:00

  • Pathophysiology of salt sensitivity hypertension.

    abstract::Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2012.671538

    authors: Ando K,Fujita T

    更新日期:2012-06-01 00:00:00

  • The role of potatoes and potato components in cardiometabolic health: a review.

    abstract::Potatoes (Solanum tuberosum) are an important food crop worldwide and contribute key nutrients to the diet, including vitamin C, potassium, and dietary fiber. Potatoes and potato components have been shown to have favorable impacts on several measures of cardiometabolic health in animals and humans, including lowering...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2013.813633

    authors: McGill CR,Kurilich AC,Davignon J

    更新日期:2013-11-01 00:00:00

  • Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination.

    abstract:BACKGROUND:Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and wheth...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890701390111

    authors: Liuba P,Aburawi EH,Pesonen E,Andersson S,Truedsson L,Ylä-Herttuala S,Holmberg L

    更新日期:2007-01-01 00:00:00

  • Changes of myocardial functions in acute hepatic porphyrias. Role of heme arginate administration.

    abstract::In three patients with attacks of acute intermittent porphyria we found markedly impaired functions of the left ventricle accompanied by ECG changes that returned to normal after administration of heme arginate or cytochrome C administration. In nine patients with other types of porphyria, and in one patient with acut...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149205

    authors: Kordac V,Kozáková M,Martásek P

    更新日期:1989-08-01 00:00:00

  • How far is the Belgian population from the recommended nutritional goals and ideal serum cholesterol? Belgian Interuniversity Research on Nutrition and Health Study Group.

    abstract::In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149946

    authors: Kornitzer MD,Dramaix MM

    更新日期:1989-06-01 00:00:00

  • Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.

    abstract:BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890701278795

    authors: Partonen T,Treutlein J,Alpman A,Frank J,Johansson C,Depner M,Aron L,Rietschel M,Wellek S,Soronen P,Paunio T,Koch A,Chen P,Lathrop M,Adolfsson R,Persson ML,Kasper S,Schalling M,Peltonen L,Schumann G

    更新日期:2007-01-01 00:00:00

  • Personalised medicine in hypercholesterolaemia: the role of pharmacogenetics in statin therapy.

    abstract::Statins are the first-line choice in Lipid-lowering therapy to reduce cardiovascular risk. In a continuous attempt to optimise treatment success, there is a need for additional research on genes and related molecular pathways that can determine the efficacy and toxicity of lipid-lowering drugs. Several variations with...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2020.1800074

    authors: Ahangari N,Doosti M,Ghayour Mobarhan M,Sahebkar A,Ferns GA,Pasdar A

    更新日期:2020-12-01 00:00:00

  • Increased plasma interleukin-1 receptor antagonist levels in men with visceral obesity.

    abstract:BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890903022801

    authors: Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JP

    更新日期:2009-01-01 00:00:00

  • Molecular genetics of anxiety in mice and men.

    abstract::Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890701747096

    authors: Hovatta I,Barlow C

    更新日期:2008-01-01 00:00:00

  • Different distribution of T cell receptor beta-chain haplotypes in mixed connective tissue disease and systemic lupus erythematosus.

    abstract::Mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) are autoimmune diseases with a genetic background, and it is reasonable to suggest that aberrations in T cell receptor (TCR) genes could contribute to these diseases, as they play an important role in immune regulation. We studied TCR beta-c...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899409147342

    authors: Ikäheimo IL,Tiilikainen AS,Hämeenkorpi R,Silvennoinen-Kassinen SH

    更新日期:1994-04-01 00:00:00

  • Exercise echocardiography in the diagnosis of coronary artery disease.

    abstract::The purpose of this study was to test the applicability of exercise echocardiography in the diagnosis of coronary artery disease. The results were compared to findings of coronary angiography. 118 patients, 100 males and 18 females, who were all referred to coronary angiography for suspected ischaemic heart disease, u...

    journal_title:Annals of medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/07853899608999078

    authors: Luotolahti M,Saraste M,Hartiala J

    更新日期:1996-02-01 00:00:00

  • Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.

    abstract:OBJECTIVE:Rapid weight loss with very-low-calorie diet (VLCD) is known to improve insulin sensitivity and decrease adipose tissue masses. The aim was to investigate the effects of VLCD on adipose tissue regional glucose uptake (rGU) and perfusion and their association with adipokines. RESEARCH DESIGN AND METHODS:Sixte...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802446754

    authors: Viljanen AP,Lautamäki R,Järvisalo M,Parkkola R,Huupponen R,Lehtimäki T,Rönnemaa T,Raitakari OT,Iozzo P,Nuutila P

    更新日期:2009-01-01 00:00:00

  • Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity.

    abstract::Due to its varied and variable phenotypes, Andersen-Tawil syndrome (ATS) holds a unique place in the field of channelopathies. Patients with ATS typically present with the triad of periodic paralysis, cardiac arrhythmias, and developmental dysmorphisms. Although penetrance of ATS is high, disease expression and severi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/17431380410032490

    authors: Donaldson MR,Yoon G,Fu YH,Ptacek LJ

    更新日期:2004-01-01 00:00:00