Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study.

Abstract:

INTRODUCTION:We studied prevalence of hypovitaminosis D, its determinants, and whether achievement of recommended dietary vitamin D intake (10 μg/d) is associated with absence of hypovitaminosis D in adults. METHODS:The study is part of the Cardiovascular Risk in Young Finns Study. We collected serum samples of 25-hydroxyvitamin D as part of the 27-year follow-up (994 men and 1,210 women aged 30-45 years). Hypovitaminosis was defined as vitamin D concentration ≤ 50 nmol/L. RESULTS:Hypovitaminosis D was found in 38% of men and 34% of women. Dietary vitamin D intake (OR 0.90, 95% CI 0.86-0.93), use of vitamin-mineral supplements (0.66, 0.51-0.85), sunny holiday (0.55, 0.41-0.75), and oral contraceptive use in women (0.45, 0.27-0.75) were independently associated with reduced odds of hypovitaminosis. Increase in body mass index (1.06, 1.03-1.09), being a smoker (1.36, 0.97-1.92), investigation month (December versus other) (1.35, 1.12-1.61), and risk alleles in genotypes rs12785878 (1.31, 1.00-1.70) and rs2282679 (2.08, 1.66-2.60) increased odds of hypovitaminosis. Hypovitaminosis D was common also when recommended dietary intake was obtained (men 29%, women 24%). CONCLUSION:Several factors were associated with hypovitaminosis D. The condition was common even when recommended vitamin D intake was reported. The results support the importance of vitamin D fortification and nutrient supplement use.

journal_name

Ann Med

journal_title

Annals of medicine

authors

Voipio AJ,Pahkala KA,Viikari JS,Mikkilä V,Magnussen CG,Hutri-Kähönen N,Kähönen M,Lehtimäki T,Männistö S,Loo BM,Jula A,Marniemi J,Juonala M,Raitakari OT

doi

10.3109/07853890.2015.1020860

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

253-62

issue

3

eissn

0785-3890

issn

1365-2060

journal_volume

47

pub_type

杂志文章
  • Mesenchymal stem cells.

    abstract::About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to differentiate under defined in vitro conditions into multiple cell types present in many different tissues, e.g. osteoblasts, chondroblasts...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890500371957

    authors: Väänänen HK

    更新日期:2005-01-01 00:00:00

  • Elevated angiogenin levels in chronic heart failure.

    abstract:BACKGROUND:Abnormal indices of angiogenesis have been reported in chronic heart failure (CHF). We tested the hypothesis that circulating angiogenin (a potent inducer of neovascularization in vivo) is higher in CHF patients compared with controls and associated with indices of CHF severity: brain natriuretic peptide (BN...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802001419

    authors: Patel JV,Sosin M,Gunarathne A,Hussain I,Davis RC,Hughes EA,Lip GY

    更新日期:2008-01-01 00:00:00

  • The role of potatoes and potato components in cardiometabolic health: a review.

    abstract::Potatoes (Solanum tuberosum) are an important food crop worldwide and contribute key nutrients to the diet, including vitamin C, potassium, and dietary fiber. Potatoes and potato components have been shown to have favorable impacts on several measures of cardiometabolic health in animals and humans, including lowering...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890.2013.813633

    authors: McGill CR,Kurilich AC,Davignon J

    更新日期:2013-11-01 00:00:00

  • Mechanisms and consequences of phagocyte adhesion to endothelium.

    abstract::Leukocyte adhesion to endothelium is essential for the development of an appropriate immune-inflammatory response. The vital importance of leukocyte-endothelial adhesive interactions in host defense and homeostasis is illustrated by the clinical manifestations of patients with congenital defects of leukocyte adhesion ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899909115974

    authors: Repo H,Harlan JM

    更新日期:1999-06-01 00:00:00

  • Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births.

    abstract::INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890.2010.546807

    authors: Donnez J,Silber S,Andersen CY,Demeestere I,Piver P,Meirow D,Pellicer A,Dolmans MM

    更新日期:2011-01-01 00:00:00

  • Mucosal immunity and viral infections.

    abstract::The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890109002074

    authors: Freihorst J,Ogra PL

    更新日期:2001-04-01 00:00:00

  • Healthy gut microflora and allergy: factors influencing development of the microbiota.

    abstract::In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899908995892

    authors: Kirjavainen PV,Gibson GR

    更新日期:1999-08-01 00:00:00

  • Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.

    abstract::Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis. The 4-hydroxyproline residues generated by the endoplasmic reticulum (ER) luminal collagen P4Hs (C-P4Hs) are essential for the stability of the collagen triple helix. Vertebrate C-P4Hs are alpha2beta...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890801986594

    authors: Myllyharju J

    更新日期:2008-01-01 00:00:00

  • Neuropeptides and their receptors in the immune system.

    abstract::Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:

    authors: van Hagen PM,Hofland LJ,ten Bokum AM,Lichtenauer-Kaligis EG,Kwekkeboom DJ,Ferone D,Lamberts SW

    更新日期:1999-10-01 00:00:00

  • How far is the Belgian population from the recommended nutritional goals and ideal serum cholesterol? Belgian Interuniversity Research on Nutrition and Health Study Group.

    abstract::In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853898909149946

    authors: Kornitzer MD,Dramaix MM

    更新日期:1989-06-01 00:00:00

  • Role of defensins in inflammatory lung disease.

    abstract::The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890252953482

    authors: Aarbiou J,Rabe KF,Hiemstra PS

    更新日期:2002-01-01 00:00:00

  • Sex, age, and time to cardioversion. Risk factors for cardioversion of acute atrial fibrillation from the FinCV study.

    abstract:BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2016.1267869

    authors: Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

    更新日期:2017-05-01 00:00:00

  • ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study.

    abstract:BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890802649738

    authors: Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

    更新日期:2009-01-01 00:00:00

  • Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults.

    abstract:BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2016.1226512

    authors: Aeschbacher S,Schoen T,Dörig L,Kreuzmann R,Neuhauser C,Schmidt-Trucksäss A,Probst-Hensch NM,Risch M,Risch L,Conen D

    更新日期:2017-02-01 00:00:00

  • Optimization of insulin treatment in children.

    abstract::Diabetes in childhood and adolescence is a difficult, lifelong, evolving disorder. Insulin treatment is essential for the establishment and maintenance of optimal metabolic control but it is only part of a comprehensive child-focused management strategy which must be initiated at the time of diagnosis. Attention must ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899708999372

    authors: Swift PG

    更新日期:1997-10-01 00:00:00

  • Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.

    abstract::Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closel...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890410018808

    authors: Johansson B,Mertens F,Mitelman F

    更新日期:2004-01-01 00:00:00

  • Assessment of endothelial (dys)function in atrial fibrillation.

    abstract::Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mec...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890903160726

    authors: Krishnamoorthy S,Lim SH,Lip GY

    更新日期:2009-01-01 00:00:00

  • Optimal chemotherapy of ovarian cancer with an old regimen.

    abstract::When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899509031947

    authors: Bertelsen K

    更新日期:1995-02-01 00:00:00

  • What is a pathogen?

    abstract::The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

    journal_title:Annals of medicine

    pub_type: 社论

    doi:10.1080/078538902317338580

    authors: Casadevall A,Pirofski LA

    更新日期:2002-01-01 00:00:00

  • Update on pathophysiology of scleroderma with special reference to immunoinflammatory events.

    abstract::Scleroderma or systemic sclerosis (SSc) is a complex disease in which the vasculopathy and the activation of the immune system with production of inflammatory mediators lead to dysregulated fibroblast activation. The resulting excessive deposition of collagens and other extracellular matrix proteins ends in fibrosis a...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890601098152

    authors: Chizzolini C

    更新日期:2007-01-01 00:00:00

  • Liver transplantation restores low serum levels of very low density and high density lipoproteins in end-stage primary biliary cirrhosis.

    abstract::Amounts of serum lipids were determined in 10 women suffering from end-stage primary biliary cirrhosis (PBC) in order to evaluate the concentrations of and changes in very low density (VLDL), high density (HDL) lipoprotein cholesterol and apoprotein A-I before and after liver transplantation. The concentrations of som...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899209148340

    authors: Nikkilä K

    更新日期:1992-04-01 00:00:00

  • Associations between sleep disturbances and diabetes mellitus among blacks with metabolic syndrome: Results from the Metabolic Syndrome Outcome Study (MetSO).

    abstract:INTRODUCTION:The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome. METHODS:This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. ...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853890.2015.1015601

    authors: Ramos AR,Wallace DM,Pandi-Perumal SR,Williams NJ,Castor C,Sevick MA,Mcfarlane SI,Jean-Louis G

    更新日期:2015-05-01 00:00:00

  • Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity.

    abstract::Due to its varied and variable phenotypes, Andersen-Tawil syndrome (ATS) holds a unique place in the field of channelopathies. Patients with ATS typically present with the triad of periodic paralysis, cardiac arrhythmias, and developmental dysmorphisms. Although penetrance of ATS is high, disease expression and severi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/17431380410032490

    authors: Donaldson MR,Yoon G,Fu YH,Ptacek LJ

    更新日期:2004-01-01 00:00:00

  • New treatment options for substance abuse from a public health viewpoint.

    abstract::Naltrexone is the first safe and effective pharmaceutical adjunct for use in the treatment of alcohol abuse. Theoretically it could be effective also as a means for terminating methadone maintenance and in the treatment of other forms of substance abuse. Two general types of protocols have been used with naltrexone. O...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.3109/07853899809029941

    authors: Sinclair JD

    更新日期:1998-08-01 00:00:00

  • Are 12-lead ECG findings associated with the risk of cardiovascular events after ischemic stroke in young adults?

    abstract:INTRODUCTION:Ischemic stroke (IS) in a young patient is a disaster and recurrent cardiovascular events could add further impairment. Identifying patients with high risk of such events is therefore important. The prognostic relevance of ECG for this population is unknown. MATERIALS AND METHODS:A total of 690 IS patient...

    journal_title:Annals of medicine

    pub_type: 杂志文章

    doi:10.1080/07853890.2016.1202443

    authors: Pirinen J,Putaala J,Aarnio K,Aro AL,Sinisalo J,Kaste M,Haapaniemi E,Tatlisumak T,Lehto M

    更新日期:2016-11-01 00:00:00

  • Antioxidants and carcinogenesis.

    abstract::It is established beyond doubt that free radicals in tissues and cells can damage DNA, proteins, carbohydrates and lipids. These potentially deleterious reactions are at least partly controlled by antioxidants capable of scavenging free radicals. It is widely believed that a proper balance between free radicals and an...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899409148366

    authors: Rautalahti M,Huttunen J

    更新日期:1994-12-01 00:00:00

  • Adoption studies of schizophrenia.

    abstract::The understanding and treatment of schizophrenia have been greatly hampered by uncertainty about etiological factors and controversy about diagnostic boundaries. Adoption studies have helped clarify both of these problems. First, the adoptees study method, the index offspring of adopting-away schizophrenic biological ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853899409147896

    authors: Tienari PJ,Wynne LC

    更新日期:1994-08-01 00:00:00

  • Cardiometabolic diseases of civilization: history and maturation of an evolving global threat. An update and call to action.

    abstract::Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult popul...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890.2016.1271957

    authors: Kones R,Rumana U

    更新日期:2017-05-01 00:00:00

  • Risk factors for rheumatoid arthritis.

    abstract::Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.1080/07853890410026025

    authors: Aho K,Heliövaara M

    更新日期:2004-01-01 00:00:00

  • Linear accelerator radiosurgery in the management of brain tumours.

    abstract::Radiosurgery is an increasingly popular method for treating a variety of intracranial tumours. A great deal of treatment data has been accumulated suggesting that radiosurgery may be the treatment of choice for small acoustic schwannomas. Moreover, radiosurgery promises excellent tumour control and minimal risk in the...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审

    doi:10.3109/07853890008995912

    authors: Friedman WA,Foote KD

    更新日期:2000-02-01 00:00:00