Abstract:
BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national FGA patient registry. METHODS:An inquiry about the known and suspected signs of FGA, sent to the members of Finnish Amyloidosis Association, telephone contacts, and hospital records were utilized to create the registry. RESULTS:A total of 227 patients were entered to the database. The first symptom was ophthalmological for 167 patients (73.6%) at the mean age of 39 years. Corneal lattice dystrophy (CLD) was reported at the mean age of 43 years. Impaired vision, polyneuropathy, facial nerve paresis, and cutis laxa appeared on average between 52 and 57 years. Carpal tunnel syndrome (CTS) was reported by 86 patients (37.9%). Nine patients (4.0%) had a pacemaker, and 12 (6.1%) had cardiomyopathy. CONCLUSIONS:The first symptom was ophthalmological in most cases. Except for CLD no prominent difference in the age of appearance was found between the major symptoms. CTS, cardiac pacemakers, and cardiomyopathy were remarkably more common compared to the general population.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula Sdoi
10.3109/07853890.2015.1075063subject
Has Abstractpub_date
2015-01-01 00:00:00pages
506-11issue
6eissn
0785-3890issn
1365-2060journal_volume
47pub_type
杂志文章abstract:OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章
doi:10.1080/07853890701233832
更新日期:2007-01-01 00:00:00
abstract::The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment stra...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890410033612
更新日期:2004-01-01 00:00:00
abstract::Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890410026025
更新日期:2004-01-01 00:00:00
abstract::This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109147935
更新日期:1991-02-01 00:00:00
abstract::Troglitazone is a novel once-daily oral antidiabetic agent for the treatment of type 2 diabetes patients. Here, we report the overall dose response characteristics of troglitazone, with respect to effects on metabolic control, using a pharmacodynamic model. Data from week 12 from two previously reported double-blind, ...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/07853899808999405
更新日期:1998-04-01 00:00:00
abstract::Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We ...
journal_title:Annals of medicine
pub_type: 杂志文章,多中心研究
doi:10.1080/07853890.2019.1613672
更新日期:2019-01-01 00:00:00
abstract::This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析,评审
doi:10.3109/07853890.2015.1071872
更新日期:2015-01-01 00:00:00
abstract::In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149946
更新日期:1989-06-01 00:00:00
abstract::The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been increasing for the last four decades. In this review determinants for an increased IgE synthesis are discussed on both an epidemiological and on an immunological level with special emphasis on the differentiation of the B cell to an IgE-produ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890701449354
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890701645399
更新日期:2008-01-01 00:00:00
abstract::Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999115
更新日期:1996-12-01 00:00:00
abstract::Inflammatory diseases are on the rise in westernized countries, but also in urbanized areas of developing countries. A number of studies have now demonstrated a negative association between helminth infections and inflammatory diseases, such as allergy, suggesting a potential role for helminth-induced immune responses...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890701436765
更新日期:2007-01-01 00:00:00
abstract::In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2020.1770849
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:This meta-analysis aimed to compare the treatment of an acute asthma attack in children in the emergency department (ED) with inhaled corticosteroids (ICS) versus placebo or oral systemic corticosteroids (SC) as assessed by the hospital admission rates. METHODS:After searching Medline, Cochrane, EMBASE, and...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析
doi:10.3109/07853890.2013.859855
更新日期:2014-02-01 00:00:00
abstract::In Europe around 1970 there were only a few small and often poorly known epidemiological studies on risk factors and the incidence of coronary heart disease. In order to enhance the utilization of the information contained in them, the Medical Clinic in Heidelberg offered uniform data analysis to qualifying contributi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149931
更新日期:1989-06-01 00:00:00
abstract::Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809002606
更新日期:1998-12-01 00:00:00
abstract::Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing comple...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310010023
更新日期:2003-01-01 00:00:00
abstract::Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899708999355
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/078538902320322547
更新日期:2002-01-01 00:00:00
abstract::The recent identification of mutations in the RET proto-oncogene that are associated with multiple endocrine neoplasia type 2 (MEN 2) syndromes has allowed therapeutic intervention in affected individuals on the basis of direct genetic testing. The principal endocrine neoplasm that occurs in patients with the MEN 2 sy...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999099
更新日期:1996-10-01 00:00:00
abstract::Although obesity and alcohol intake as well as dietary sodium, potassium and magnesium are the major non-genetic determinants of blood pressure levels, interest has recently been stimulated in the function of fatty acids and antioxidants in the aetiology of hypertension. In the Kuopio Ischaemic Heart Disease Risk Fact...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899109148063
更新日期:1991-08-01 00:00:00
abstract:AIM:Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined. METHODS:We ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2018.1523549
更新日期:2018-11-01 00:00:00
abstract:AIMS:This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile site...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890903325360
更新日期:2010-01-01 00:00:00
abstract::The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...
journal_title:Annals of medicine
pub_type: 社论
doi:10.1080/078538902317338580
更新日期:2002-01-01 00:00:00
abstract::Depression, among other mood disorders, represents one of the most common health problems worldwide, with steadily increasing incidence and major socio-economic consequences. However, since the knowledge about the underlying pathophysiological principles is still very scanty, depression and other mood disorders are cu...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853891003769957
更新日期:2010-05-06 00:00:00
abstract::Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/17431380410032643
更新日期:2004-01-01 00:00:00
abstract::This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002063
更新日期:2001-03-01 00:00:00
abstract::Vulvodynia is a complex multifactorial and multidisciplinary clinical syndrome of unexplained vulvar pain, sexual dysfunction, and psychological disability. Because of the absence of abnormal physical findings among such patients, vulvodynia was long thought to be solely a psychosomatic syndrome. The incidence or prev...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899509031955
更新日期:1995-04-01 00:00:00
abstract::Serum trace element concentrations, parameters of iron metabolism and serum protein concentrations were investigated in thirteen adult recipients of bone-marrow transplants receiving total parenteral nutrition. Six of the patients died during the four weeks follow-up. Serum zinc concentrations were initially low but i...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899209164145
更新日期:1992-02-01 00:00:00
abstract::Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209147839
更新日期:1992-10-01 00:00:00