Abstract:
:Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's disease, frontotemporal dementia, prion diseases and other dementing disorders are now well characterized, mainly due to the discovery of genes causing dominantly inherited disease forms (Table 1). As of today, no efficient pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Ingelsson M,Hyman BTdoi
10.1080/078538902320322529subject
Has Abstractpub_date
2002-01-01 00:00:00pages
259-71issue
4eissn
0785-3890issn
1365-2060journal_volume
34pub_type
杂志文章,评审abstract::More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890009002033
更新日期:2000-12-01 00:00:00
abstract:INTRODUCTION:Undetermined strokes with an embolic pattern (USEP) represent a common phenotype. We assessed their frequency and compared USEP with cardioembolic stroke with a known source and non-cardioembolic stroke etiology. METHODS:Study patients were 540 consecutive ischemic stroke patients admitted to Helsinki Uni...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1057612
更新日期:2015-01-01 00:00:00
abstract::Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence it...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2016.1243802
更新日期:2017-05-01 00:00:00
abstract::This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809002485
更新日期:1998-10-01 00:00:00
abstract::Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899309147861
更新日期:1993-02-01 00:00:00
abstract::Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310004903
更新日期:2003-01-01 00:00:00
abstract::Clinical know-how and skills as well as up-to-date scientific evidence are cornerstones for providing effective treatment for patients. However, in order to improve the effectiveness of treatment in ordinary practice, also appropriate documentation of care at the health care units and benchmarking based on this docume...
journal_title:Annals of medicine
pub_type: 社论
doi:10.3109/07853890.2011.653394
更新日期:2013-03-01 00:00:00
abstract::Amounts of serum lipids were determined in 10 women suffering from end-stage primary biliary cirrhosis (PBC) in order to evaluate the concentrations of and changes in very low density (VLDL), high density (HDL) lipoprotein cholesterol and apoprotein A-I before and after liver transplantation. The concentrations of som...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209148340
更新日期:1992-04-01 00:00:00
abstract::Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890802552437
更新日期:2009-01-01 00:00:00
abstract::The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment stra...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890410033612
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated. METHODS:A total ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2010.503660
更新日期:2010-10-01 00:00:00
abstract::The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecul...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890600995010
更新日期:2006-01-01 00:00:00
abstract::Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. The migration and accumulation of inflammatory cells that follow leukotriene rece...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890600982737
更新日期:2006-01-01 00:00:00
abstract::With the last two decades, the importance of genetic factors in the aetiology of major mental illness has been firmly re-established and psychiatric research has now firmly embraced the era of molecular genetics. Despite a number of false starts in the study of schizophrenia and affective disorder, there have been suc...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899209147816
更新日期:1992-06-01 00:00:00
abstract::In the last three decades the incidence of metabolic syndrome (MetS) has been growing worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). In children and adolescents such epidemics are particularly worrisome, since the metabolic consequences in adulthoo...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2010.547869
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (AGel amyloidosis) is an autosomal dominant disorder. Until recently, there has only been little knowledge of fatal complications of the disease and its possible impact on the patients' life span. METHODS:We identified 272 deceased patients based on patient in...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2016.1177197
更新日期:2016-08-01 00:00:00
abstract::Hypertension is a major cardiovascular risk factor with a multifactorial pathogenesis, including genetic and environmental factors. In addition to hypothesis-driven strategies, unbiased approaches such as genomics, proteomics, and metabolomics are useful tools to help unravel the pathophysiology of hypertension and as...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2012.660494
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Several studies have suggested that the occurrence of severe hypoglycemia during sleep may be more dangerous for cardiac arrhythmia than that in the day-time. METHODS:We performed a retrospective study between January 2006 and March 2012 to assess electrocardiograms during severe hypoglycemia in patients wi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1017528
更新日期:2015-05-01 00:00:00
abstract::Naltrexone is the first safe and effective pharmaceutical adjunct for use in the treatment of alcohol abuse. Theoretically it could be effective also as a means for terminating methadone maintenance and in the treatment of other forms of substance abuse. Two general types of protocols have been used with naltrexone. O...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899809029941
更新日期:1998-08-01 00:00:00
abstract::Molecular oxygen (O2)is a basic requirement for cellular growth and viability and many aspects of anatomy and physiology are dedicated to achieving reliable distribution. Recent work has identified a specific sensing and response system, centred around a transcription complex called Hypoxia-inducible Factor 1 (HIF-1),...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/0785389031000458233
更新日期:2003-01-01 00:00:00
abstract::The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009147261
更新日期:1990-06-01 00:00:00
abstract:INTRODUCTION:Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS:We searched databases to identify randomized trials with controlled human exposures to ...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析
doi:10.1080/07853890.2016.1252054
更新日期:2017-03-01 00:00:00
abstract::The phenomenon of treatment-resistant depression (TRD), described as the occurrence of an inadequate response after an adequate treatment with antidepressant agents (in terms of dose, duration, and adherence), is very common in clinical practice. It has been broadly defined in the context of unipolar major depression,...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.583675
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/078538902320322547
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2018.1505052
更新日期:2018-09-01 00:00:00
abstract::In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908995892
更新日期:1999-08-01 00:00:00
abstract::Regenerative medicine is a multidisciplinary field utilizing the potential of stem cells and the regenerative capability of the body to restore, maintain, or enhance tissue and organ functions. Stem cells are unspecialized cells that can self-renew but also differentiate into several somatic cells when subjected the a...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.573805
更新日期:2012-11-01 00:00:00
abstract::The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; th...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2017.1392595
更新日期:2018-03-01 00:00:00
abstract::Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809005852
更新日期:1998-06-01 00:00:00
abstract::Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209167007
更新日期:1992-12-01 00:00:00