Polymorphic oxidation of debrisoquine in bladder cancer.

Abstract:

:The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of frequencies of metabolic ratio values tended to have lower values in the patients (P less than 0.05), reflecting a higher oxidative rate of debrisoquine in urothelioma patients that cannot be explained solely in terms of enzymatic induction by drugs, tobacco or alcohol. Patients with a high occupational risk for urothelioma had lower metabolic ratio values (P = 0.03). Our results suggest that oxidative polymorphism of debrisoquine might be related to the pathogenesis of bladder cancer.

journal_name

Ann Med

journal_title

Annals of medicine

authors

Benítez J,Ladero JM,Fernández-Gundín MJ,Llerena A,Cobaleda J,Martínez C,Muñoz JJ,Vargas E,Prados J,González-Rozas F

doi

10.3109/07853899009147261

subject

Has Abstract,Author List Incomplete

pub_date

1990-06-01 00:00:00

pages

157-60

issue

3

eissn

0785-3890

issn

1365-2060

journal_volume

22

pub_type

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