Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor.

abstract：:Atherosclerosis is an inflammatory disease of the vessel wall, characterized by the accumulation of leukocytes, especially macrophages and T-cells. Chemokines are small heparin-binding polypeptides, whose main function is to attract cells to the areas of developing inflammation. They function by ligating G-protein cou...

journal_title：Annals of medicine

authors： Sheikine Y,Hansson GK

更新日期：2004-01-01 00:00:00

abstract：:The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

journal_title：Annals of medicine

authors： Casadevall A,Pirofski LA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：:The Benchmarking Controlled Trial (BCT) is a novel concept which covers all observational studies aiming to assess effectiveness. BCTs provide evidence of the comparative effectiveness between health service providers, and of effectiveness due to particular features of the health and social care systems. BCTs compleme...

journal_title：Annals of medicine

authors： Malmivaara A

更新日期：2015-06-01 00:00:00

abstract：:The circadian rhythms of night shift workers do not usually adjust to their unusual work and sleep schedules, reducing their quality of life and producing potentially dangerous health and safety problems. This paper reviews field studies of simulated night work in which shifted light-dark cycles were constructed with ...

journal_title：Annals of medicine

authors： Eastman CI,Martin SK

更新日期：1999-04-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

journal_title：Annals of medicine

authors： Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

更新日期：1995-02-01 00:00:00

abstract：:Thymoma is an unusual tumour, but it is the most common malignancy in the anterior mediastinum. This tumour is unique in its frequent association with paraneoplastic syndrome and its potential for indolent growth. The distinction between thymomas and other tumours which arise in the anterior or superior mediastinum is...

journal_title：Annals of medicine

authors： Loehrer PJ Sr

更新日期：1999-10-01 00:00:00

abstract：:Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...

journal_title：Annals of medicine

authors： Tuomilehto-Wolf E,Tuomilehto J,Hitman GA

更新日期：1992-12-01 00:00:00

abstract：:Although obesity and alcohol intake as well as dietary sodium, potassium and magnesium are the major non-genetic determinants of blood pressure levels, interest has recently been stimulated in the function of fatty acids and antioxidants in the aetiology of hypertension. In the Kuopio Ischaemic Heart Disease Risk Fact...

journal_title：Annals of medicine

authors： Salonen JT

更新日期：1991-08-01 00:00:00

abstract：:On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...

journal_title：Annals of medicine

authors： Davignon J,Dallongeville J,Roederer G,Roy M,Fruchart JC,Kessling AM,Bouthillier D,Lussier-Cacan S

更新日期：1991-04-01 00:00:00

abstract：:Objective: Investigation of the clinical potential of extensive phenotype data and machine learning (ML) in the prediction of mortality in acute coronary syndrome (ACS). Methods: The value of ML and extensive clinical data was analyzed in a retrospective registry study of 9066 consecutive ACS patients (January 2007 to...

journal_title：Annals of medicine

authors： Hernesniemi JA,Mahdiani S,Tynkkynen JA,Lyytikäinen LP,Mishra PP,Lehtimäki T,Eskola M,Nikus K,Antila K,Oksala N

更新日期：2019-03-01 00:00:00

abstract：:Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine...

journal_title：Annals of medicine

authors： Nammas W,Koistinen J,Paana T,Karjalainen PP

更新日期：2017-08-01 00:00:00

abstract：:Statins are the first-line choice in Lipid-lowering therapy to reduce cardiovascular risk. In a continuous attempt to optimise treatment success, there is a need for additional research on genes and related molecular pathways that can determine the efficacy and toxicity of lipid-lowering drugs. Several variations with...

journal_title：Annals of medicine

authors： Ahangari N,Doosti M,Ghayour Mobarhan M,Sahebkar A,Ferns GA,Pasdar A

更新日期：2020-12-01 00:00:00

abstract：:Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

journal_title：Annals of medicine

authors： Patton GC

更新日期：1992-08-01 00:00:00

abstract：:Rapid prototyping (RP) is a common name for several techniques, which read in data from computer-aided design (CAD) drawings and manufacture automatically three-dimensional objects layer-by-layer according to the virtual design. The utilization of RP in tissue engineering enables the production of three-dimensional sc...

journal_title：Annals of medicine

authors： Peltola SM,Melchels FP,Grijpma DW,Kellomäki M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN:We analysed data of 2176 men aged 42-61 years free from VTE in...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Katechia DT,Laukkanen JA

更新日期：2018-05-01 00:00:00

abstract：:Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult popul...

journal_title：Annals of medicine

authors： Kones R,Rumana U

更新日期：2017-05-01 00:00:00

abstract：:In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de...

journal_title：Annals of medicine

authors： Kirjavainen PV,Gibson GR

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Mortality from coronary heart disease (CHD) has been constantly higher in eastern late settlement regions compared to western early settlements in Finland, unrelated to classical risk factors. In line with this, eastern birthplace was an age-dependent predictor of severe coronary atherosclerosis and pre-hosp...

journal_title：Annals of medicine

authors： Tyynelä P,Goebeler S,Ilveskoski E,Mikkelsson J,Perola M,Lehtimäki T,Karhunen PJ

更新日期：2013-05-01 00:00:00

abstract：:Circadian rhythms are a cardinal feature of living organisms. The stereotypical organization of homeostatic, endocrine and behavioural variables around the 24-hour cycle constitutes one of the most conserved attributes among species. It is now well established that circadian rhythmicity is not a learned behaviour, but...

journal_title：Annals of medicine

authors： Florez JC,Takahashi JS

更新日期：1995-08-01 00:00:00

abstract：:Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

journal_title：Annals of medicine

authors： Aho K,Heliövaara M

更新日期：2004-01-01 00:00:00

abstract：:Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...

journal_title：Annals of medicine

authors： Carey TE

更新日期：1996-06-01 00:00:00

abstract：:The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins...

journal_title：Annals of medicine

authors： Aarbiou J,Rabe KF,Hiemstra PS

更新日期：2002-01-01 00:00:00

abstract：:The phenomenon of treatment-resistant depression (TRD), described as the occurrence of an inadequate response after an adequate treatment with antidepressant agents (in terms of dose, duration, and adherence), is very common in clinical practice. It has been broadly defined in the context of unipolar major depression,...

journal_title：Annals of medicine

authors： Vieta E,Colom F

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Rapid weight loss with very-low-calorie diet (VLCD) is known to improve insulin sensitivity and decrease adipose tissue masses. The aim was to investigate the effects of VLCD on adipose tissue regional glucose uptake (rGU) and perfusion and their association with adipokines. RESEARCH DESIGN AND METHODS:Sixte...

journal_title：Annals of medicine

authors： Viljanen AP,Lautamäki R,Järvisalo M,Parkkola R,Huupponen R,Lehtimäki T,Rönnemaa T,Raitakari OT,Iozzo P,Nuutila P

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...

journal_title：Annals of medicine

authors： Janatuinen T,Friberg J,Viljanen MK,Raitakari OT,Nuutila P,Vainionpää R,Oksi J,Peltonen R,Engblom E,Laine H,Knuuti J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Abnormal indices of angiogenesis have been reported in chronic heart failure (CHF). We tested the hypothesis that circulating angiogenin (a potent inducer of neovascularization in vivo) is higher in CHF patients compared with controls and associated with indices of CHF severity: brain natriuretic peptide (BN...

journal_title：Annals of medicine

authors： Patel JV,Sosin M,Gunarathne A,Hussain I,Davis RC,Hughes EA,Lip GY

更新日期：2008-01-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is phenotypically and genotypically a heterogeneous disease. Since 1989, four chromosomal loci have been identified for HCM and the genes residing on three of these have been identified as beta-myosin heavy chain (beta-MHC), cardiac troponin-T and alpha-tropomyosin. These genes code f...

journal_title：Annals of medicine

authors： Durand JB,Abchee AB,Roberts R

更新日期：1995-06-01 00:00:00