Abstract:
BACKGROUND:There is an unmet need for a straightforward and cost-effective assessment of multiple lipoprotein risk factors for vascular diseases. AIMS:1) To study the relation of various lipoprotein lipid and apolipoprotein (apo) measures on the Friedewald inputs, i.e. plasma triglycerides (TG), cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C). 2) To build up regression models for the appropriate measures based solely on the Friedewald inputs. METHODS:Data were available for 1,775 plasma samples, from which very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), and HDL were also isolated by ultracentrifugation. For HDL(2)-C and apolipoproteins, 343 and 247 samples were available, respectively. RESULTS:Accurate models were obtained for VLDL-TG (cross-validation r=0.98), LDL-C (r=0.91), HDL(2)-C (r=0.92), apoA-I (r=0.92), and apoB (r=0.95). A semi-quantitative model was obtained for IDL-C (r=0.78). Due to the anticipated role of IDL-C in atherosclerosis, it was still kept within the accepted models and pursued further. The associations of the estimates with premature deaths were studied in 4,084 patients with type 1 diabetes. The associations of IDL-C and LDL-C were markedly different, the best predictors of mortality being apoB, apoB to apoA-I ratio, and IDL-C. CONCLUSIONS:The new models allow identification of clinically relevant lipoprotein profiles with no added cost to the conventional Friedewald formula.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Niemi J,Mäkinen VP,Heikkonen J,Tenkanen L,Hiltunen Y,Hannuksela ML,Jauhiainen M,Forsblom C,Taskinen MR,Kesäniemi YA,Savolainen MJ,Kaski K,Groop PH,Kovanen PT,Ala-Korpela Mdoi
10.1080/07853890902893392subject
Has Abstractpub_date
2009-01-01 00:00:00pages
451-61issue
6eissn
0785-3890issn
1365-2060pii
910900055journal_volume
41pub_type
杂志文章abstract::The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...
journal_title:Annals of medicine
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