Establishing the dose response curve for metabolic control with troglitazone, an insulin action enhancer, in type 2 diabetes patients.

abstract：:We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

journal_title：Annals of medicine

authors： Salonen R,Salonen JT

更新日期：1991-02-01 00:00:00

abstract：AIMS:This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile site...

journal_title：Annals of medicine

authors： Highet AR,Berry AM,Goldwater PN

更新日期：2010-01-01 00:00:00

abstract：:The metabolic syndrome, which is very common in the general population, is defined by the clustering of several classic cardiovascular risk factors, such as type 2 diabetes, hypertension, high triglycerides and low high-density lipoprotein cholesterol (HDL). Central obesity and insulin resistance, which are the two un...

journal_title：Annals of medicine

authors： Bonora E

更新日期：2006-01-01 00:00:00

abstract：:This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...

journal_title：Annals of medicine

authors： Keltikangas-Järvinen L,Räikkönen K,Keskivaara P,Pietikäinen M,Viikari J,Kaprio EA,Akerblom HK

更新日期：1991-02-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:Depression, among other mood disorders, represents one of the most common health problems worldwide, with steadily increasing incidence and major socio-economic consequences. However, since the knowledge about the underlying pathophysiological principles is still very scanty, depression and other mood disorders are cu...

journal_title：Annals of medicine

authors： Pollak DD,Rey CE,Monje FJ

更新日期：2010-05-06 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

journal_title：Annals of medicine

authors： Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

更新日期：1991-10-01 00:00:00

abstract：:The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins...

journal_title：Annals of medicine

authors： Aarbiou J,Rabe KF,Hiemstra PS

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS:We searched databases to identify randomized trials with controlled human exposures to ...

journal_title：Annals of medicine

authors： Vieira JL,Macedo FY,Benjo AM,Guimarães GV,Contreras JP,Bocchi EA

更新日期：2017-03-01 00:00:00

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：:Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

journal_title：Annals of medicine

authors： Koren G

更新日期：2004-01-01 00:00:00

abstract：:The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...

journal_title：Annals of medicine

authors： Benítez J,Ladero JM,Fernández-Gundín MJ,Llerena A,Cobaleda J,Martínez C,Muñoz JJ,Vargas E,Prados J,González-Rozas F

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

journal_title：Annals of medicine

authors： Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

更新日期：2009-01-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...

journal_title：Annals of medicine

authors： Rüegg C,Zaric J,Stupp R

更新日期：2003-01-01 00:00:00

abstract：:Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...

journal_title：Annals of medicine

authors： Lippi G,Franchini M,Montagnana M,Favaloro EJ

更新日期：2012-08-01 00:00:00

abstract：:Recent results from controlled trials of adjuvant tamoxifen and oophorectomy in early breast cancer are reviewed. The results of the statistical overview performed by the Early Breast Cancer Trialists Collaborative Group are summarised, and some important questions left open by this overview are discussed. These inclu...

journal_title：Annals of medicine

authors： Blomqvist CP,Elomaa I,Rissanen P

更新日期：1992-04-01 00:00:00

abstract：AIM:To evaluate the effects of canrenone compared to placebo on blood pressure control, some non-conventional biomarkers in cardiovascular stratification, and on metalloproteinases in patients affected by metabolic syndrome. METHODS:A total of 156 Caucasian patients were treated with placebo or canrenone, 50 mg once a...

journal_title：Annals of medicine

authors： Derosa G,Romano D,Bianchi L,D'Angelo A,Maffioli P

更新日期：2015-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...

journal_title：Annals of medicine

authors： Griffin BE,Xue SA

更新日期：1998-06-01 00:00:00

abstract：:Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...

journal_title：Annals of medicine

authors： Johansen K,Theorell H,Karlsson J,Diamant B,Folkers K

更新日期：1991-12-01 00:00:00

abstract：:Diabetes in childhood and adolescence is a difficult, lifelong, evolving disorder. Insulin treatment is essential for the establishment and maintenance of optimal metabolic control but it is only part of a comprehensive child-focused management strategy which must be initiated at the time of diagnosis. Attention must ...

journal_title：Annals of medicine

authors： Swift PG

更新日期：1997-10-01 00:00:00

abstract：:In the Netherlands there are about 9700 explicit requests for euthanasia or physician-assisted suicide (EAS) each year, of which approximately 3600 are granted. Other countries have criticized the Dutch policy concerning EAS. It has been suggested that palliative care in the Netherlands is not adequate and that euthan...

journal_title：Annals of medicine

authors： Swarte NB,Heintz AP

更新日期：1999-12-01 00:00:00

abstract：:Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pat...

journal_title：Annals of medicine

authors： Jeffery CJ

更新日期：2003-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00

abstract：:Cardiac arrhythmias cause more than 300,000 sudden deaths each year in the USA alone. Long QT syndrome (LQT) is a cardiac disorder that causes sudden death from ventricular tachyarrhythmias, specifically torsade de pointes. Four LQT genes have been identified: KVLQT1 (LQT1) on chromosome 11p15.5, HERG (LQT2) on chromo...

journal_title：Annals of medicine

authors： Wang Q,Chen Q,Towbin JA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...

journal_title：Annals of medicine

authors： Taskinen MR

更新日期：1998-10-01 00:00:00

abstract：:Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...

journal_title：Annals of medicine

authors： Tenkanen H,Ehnholm C

更新日期：1992-10-01 00:00:00