Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice.

abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...

journal_title：Annals of medicine

authors： Shivalkar B,Goovaerts I,Salgado RA,Ozsarlak O,Bosmans J,Parizel PM,Vrints CJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...

journal_title：Annals of medicine

authors： González Silva Y,Abad Manteca L,de la Red Gallego H,Álvarez Muñoz M,Rodríguez Carbajo M,Murcia Casado T,Ausín Pérez L,Abadía Otero J,Pérez-Castrillón JL

更新日期：2018-09-01 00:00:00

abstract：:Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...

journal_title：Annals of medicine

authors： Huikuri HV

更新日期：1997-08-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common among the severe cardiac arrhythmias and carries a significant risk of mortality and morbidity in the general population. The most important complication is represented by development of one or more thrombi in the left atrium of the dyskinetic heart, and their successive cer...

journal_title：Annals of medicine

authors： Danese E,Montagnana M,Cervellin G,Lippi G

更新日期：2014-09-01 00:00:00

abstract：:High-dose chemotherapy followed by transplantation of autologous hematopoietic progenitor cells has a proven track record of safety and efficacy in hematological malignancies and select solid tumors. The near-universal use of peripheral blood stem cells as source for autografts, routine growth factor support, and anti...

journal_title：Annals of medicine

authors： Hamadani M

更新日期：2014-12-01 00:00:00

abstract：:In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...

journal_title：Annals of medicine

authors： Wilhelmi de Toledo F,Grundler F,Sirtori CR,Ruscica M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...

journal_title：Annals of medicine

authors： Aeschbacher S,Schoen T,Dörig L,Kreuzmann R,Neuhauser C,Schmidt-Trucksäss A,Probst-Hensch NM,Risch M,Risch L,Conen D

更新日期：2017-02-01 00:00:00

abstract：:Nitric oxide (NO), derived from the vascular endothelium and other cells of the cardiovascular system, has important roles in physiological regulation of blood flow and may have pathophysiological functions in cardiovascular disease. The mechanisms involved in NO-induced vasodilatation and cytotoxicity are briefly rev...

journal_title：Annals of medicine

authors： Dusting GJ,Macdonald PS

更新日期：1995-06-01 00:00:00

abstract：:Circadian rhythms are a cardinal feature of living organisms. The stereotypical organization of homeostatic, endocrine and behavioural variables around the 24-hour cycle constitutes one of the most conserved attributes among species. It is now well established that circadian rhythmicity is not a learned behaviour, but...

journal_title：Annals of medicine

authors： Florez JC,Takahashi JS

更新日期：1995-08-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in sper...

journal_title：Annals of medicine

authors： Tapanainen JS,Aittomäki K,Huhtaniemi IT

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Khunti K

更新日期：2018-09-01 00:00:00

abstract：:Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's d...

journal_title：Annals of medicine

authors： Ingelsson M,Hyman BT

更新日期：2002-01-01 00:00:00

abstract：:Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...

journal_title：Annals of medicine

authors： Huch R,Huch A

更新日期：1993-06-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00

abstract：:Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...

journal_title：Annals of medicine

authors： Tuomilehto-Wolf E,Tuomilehto J,Hitman GA

更新日期：1992-12-01 00:00:00

abstract：:We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

journal_title：Annals of medicine

authors： Salonen R,Salonen JT

更新日期：1991-02-01 00:00:00

abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...

journal_title：Annals of medicine

authors： Taskinen MR

更新日期：1998-10-01 00:00:00

abstract：:Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic aut...

journal_title：Annals of medicine

authors： Bespalova IN,Buxbaum JD

更新日期：2003-01-01 00:00:00

abstract：:On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...

journal_title：Annals of medicine

authors： Davignon J,Dallongeville J,Roederer G,Roy M,Fruchart JC,Kessling AM,Bouthillier D,Lussier-Cacan S

更新日期：1991-04-01 00:00:00

abstract：:Rapid prototyping (RP) is a common name for several techniques, which read in data from computer-aided design (CAD) drawings and manufacture automatically three-dimensional objects layer-by-layer according to the virtual design. The utilization of RP in tissue engineering enables the production of three-dimensional sc...

journal_title：Annals of medicine

authors： Peltola SM,Melchels FP,Grijpma DW,Kellomäki M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national ...

journal_title：Annals of medicine

authors： Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula S

更新日期：2015-01-01 00:00:00

abstract：:The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins...

journal_title：Annals of medicine

authors： Aarbiou J,Rabe KF,Hiemstra PS

更新日期：2002-01-01 00:00:00

abstract：:Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to ...

journal_title：Annals of medicine

authors： Virkkunen M,Linnoila M

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the ...

journal_title：Annals of medicine

authors： Halverson T,Alagiakrishnan K

更新日期：2020-12-01 00:00:00

abstract：:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...

journal_title：Annals of medicine

authors： Akerblom HK,Viikari J,Raitakari OT,Uhari M

更新日期：1999-04-01 00:00:00

abstract：:Epidemiological and experimental studies indicate an inverse relationship between the risk of colon cancer development and intake of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). All NSAIDs are known inhibitors of cyclo-oxygenase, the enzyme responsible for converting arachidonic acid to prostagland...

journal_title：Annals of medicine

authors： Gustafson-Svärd C,Lilja I,Hallböök O,Sjödahl R

更新日期：1997-06-01 00:00:00

abstract：:In Europe around 1970 there were only a few small and often poorly known epidemiological studies on risk factors and the incidence of coronary heart disease. In order to enhance the utilization of the information contained in them, the Medical Clinic in Heidelberg offered uniform data analysis to qualifying contributi...

journal_title：Annals of medicine

authors： Lamm G

更新日期：1989-06-01 00:00:00

abstract：:The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

journal_title：Annals of medicine

authors： Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

更新日期：1995-02-01 00:00:00

abstract：:In the last three decades the incidence of metabolic syndrome (MetS) has been growing worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). In children and adolescents such epidemics are particularly worrisome, since the metabolic consequences in adulthoo...

journal_title：Annals of medicine

authors： Alisi A,Cianfarani S,Manco M,Agostoni C,Nobili V

更新日期：2012-02-01 00:00:00