DQA1 and DQB1 heterodimers in insulin-dependent diabetes mellitus: a genetic-epidemiological study in Finland. DiMe Study Group.

abstract：:There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...

journal_title：Annals of medicine

authors： Rinne JO

更新日期：1999-12-01 00:00:00

abstract：:In three patients with attacks of acute intermittent porphyria we found markedly impaired functions of the left ventricle accompanied by ECG changes that returned to normal after administration of heme arginate or cytochrome C administration. In nine patients with other types of porphyria, and in one patient with acut...

journal_title：Annals of medicine

authors： Kordac V,Kozáková M,Martásek P

更新日期：1989-08-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...

journal_title：Annals of medicine

authors： Rüegg C,Zaric J,Stupp R

更新日期：2003-01-01 00:00:00

abstract：:Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-te...

journal_title：Annals of medicine

authors： Michels H

更新日期：1997-10-01 00:00:00

abstract：:The pathophysiology of psychotic and other symptoms in schizophrenia remains a mystery despite decades of research. Even though it has been suspected for many years that autoimmune mechanisms may play a role in the pathophysiology of schizophrenia, firm evidence for this hypothesis has been lacking. Our studies, over ...

journal_title：Annals of medicine

authors： Ganguli R,Brar JS,Chengappa KN,Yang ZW,Nimgaonkar VL,Rabin BS

更新日期：1993-10-01 00:00:00

abstract：:The goals of this chapter are to provide a brief review of the biology of the protein C pathway and some of the features of the pathway that make it uniquely positioned to control microvascular coagulation and control the acute inflammatory response. Activated protein C works as an antithrombotic agent by inactivating...

journal_title：Annals of medicine

authors： Esmon CT

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...

journal_title：Annals of medicine

authors： Baldassarre D,De Jong A,Amato M,Werba JP,Castelnuovo S,Frigerio B,Veglia F,Tremoli E,Sirtori CR

更新日期：2008-01-01 00:00:00

abstract：:Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine...

journal_title：Annals of medicine

authors： Nammas W,Koistinen J,Paana T,Karjalainen PP

更新日期：2017-08-01 00:00:00

abstract：AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...

journal_title：Annals of medicine

authors： Miedel C,Leander K,de Faire U,Gigante B

更新日期：2015-01-01 00:00:00

abstract：:Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

journal_title：Annals of medicine

authors： Koren G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...

journal_title：Annals of medicine

authors： Partonen T,Treutlein J,Alpman A,Frank J,Johansson C,Depner M,Aron L,Rietschel M,Wellek S,Soronen P,Paunio T,Koch A,Chen P,Lathrop M,Adolfsson R,Persson ML,Kasper S,Schalling M,Peltonen L,Schumann G

更新日期：2007-01-01 00:00:00

abstract：:Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We ...

journal_title：Annals of medicine

authors： Pérez-Belmonte LM,Osuna-Sánchez J,Millán-Gómez M,López-Carmona MD,Gómez-Doblas JJ,Cobos-Palacios L,Sanz-Cánovas J,Barbancho MA,Lara JP,Jiménez-Navarro M,Bernal-López MR,Gómez-Huelgas R

更新日期：2019-01-01 00:00:00

abstract：:Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na...

journal_title：Annals of medicine

authors： Ando K,Fujita T

更新日期：2012-06-01 00:00:00

abstract：:Potatoes (Solanum tuberosum) are an important food crop worldwide and contribute key nutrients to the diet, including vitamin C, potassium, and dietary fiber. Potatoes and potato components have been shown to have favorable impacts on several measures of cardiometabolic health in animals and humans, including lowering...

journal_title：Annals of medicine

authors： McGill CR,Kurilich AC,Davignon J

更新日期：2013-11-01 00:00:00

abstract：:Rapid prototyping (RP) is a common name for several techniques, which read in data from computer-aided design (CAD) drawings and manufacture automatically three-dimensional objects layer-by-layer according to the virtual design. The utilization of RP in tissue engineering enables the production of three-dimensional sc...

journal_title：Annals of medicine

authors： Peltola SM,Melchels FP,Grijpma DW,Kellomäki M

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Aiming at identifying biomarkers for hypertrophic cardiomyopathy (HCM), the serum proteome was explored through a two-dimensional gel-based proteomic approach (2D-DIGE) coupled with mass spectrometry and database interrogation. METHODS:Serum samples from 20 male HCM patients and their sex- and age-matched...

journal_title：Annals of medicine

authors： Orenes-Piñero E,Hernández-Romero D,de Torre C,Vilchez JA,Martínez M,Romero-Aniorte AI,Climent V,García-Honrubia A,Valdés M,Marín F

更新日期：2013-06-01 00:00:00

abstract：:In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...

journal_title：Annals of medicine

authors： Kornitzer MD,Dramaix MM

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (AGel amyloidosis) is an autosomal dominant disorder. Until recently, there has only been little knowledge of fatal complications of the disease and its possible impact on the patients' life span. METHODS:We identified 272 deceased patients based on patient in...

journal_title：Annals of medicine

authors： Schmidt EK,Atula S,Tanskanen M,Nikoskinen T,Notkola IL,Kiuru-Enari S

更新日期：2016-08-01 00:00:00

abstract：:The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...

journal_title：Annals of medicine

authors： Benítez J,Ladero JM,Fernández-Gundín MJ,Llerena A,Cobaleda J,Martínez C,Muñoz JJ,Vargas E,Prados J,González-Rozas F

更新日期：1990-06-01 00:00:00

abstract：:Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic aut...

journal_title：Annals of medicine

authors： Bespalova IN,Buxbaum JD

更新日期：2003-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common among the severe cardiac arrhythmias and carries a significant risk of mortality and morbidity in the general population. The most important complication is represented by development of one or more thrombi in the left atrium of the dyskinetic heart, and their successive cer...

journal_title：Annals of medicine

authors： Danese E,Montagnana M,Cervellin G,Lippi G

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...

journal_title：Annals of medicine

authors： Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JP

更新日期：2009-01-01 00:00:00

abstract：:The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...

journal_title：Annals of medicine

authors： Kronborg O

更新日期：1991-10-01 00:00:00

abstract：:Hypertension is a major cardiovascular risk factor with a multifactorial pathogenesis, including genetic and environmental factors. In addition to hypothesis-driven strategies, unbiased approaches such as genomics, proteomics, and metabolomics are useful tools to help unravel the pathophysiology of hypertension and as...

journal_title：Annals of medicine

authors： Delles C,Neisius U,Carty DM

更新日期：2012-06-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00

abstract：:Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...

journal_title：Annals of medicine

authors： Hovatta I,Barlow C

更新日期：2008-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...

journal_title：Annals of medicine

authors： Griffin BE,Xue SA

更新日期：1998-06-01 00:00:00

abstract：:The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

journal_title：Annals of medicine

authors： Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

更新日期：1995-02-01 00:00:00

abstract：:During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

journal_title：Annals of medicine

authors： Borch K

更新日期：1989-08-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00