Elevated serum ICTP concentrations reflect poor prognosis in patients with ovarian carcinoma.

abstract：BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...

journal_title：Annals of medicine

authors： Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JP

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN:We analysed data of 2176 men aged 42-61 years free from VTE in...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Katechia DT,Laukkanen JA

更新日期：2018-05-01 00:00:00

abstract：:The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...

journal_title：Annals of medicine

authors： Kronborg O

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

journal_title：Annals of medicine

authors： Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

更新日期：2009-01-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

journal_title：Annals of medicine

authors： Jafar-Mohammadi B,McCarthy MI

更新日期：2008-01-01 00:00:00

abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...

journal_title：Annals of medicine

authors： Taskinen MR

更新日期：1998-10-01 00:00:00

abstract：:Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...

journal_title：Annals of medicine

authors： van Hagen PM,Hofland LJ,ten Bokum AM,Lichtenauer-Kaligis EG,Kwekkeboom DJ,Ferone D,Lamberts SW

更新日期：1999-10-01 00:00:00

abstract：:One of the major discoveries in modern genetics is the phenomenon of genomic, or parental, imprinting. The parent-of-origin effects seen after transmission of an imprinted gene from parents to their children do not follow the genetic rules postulated by Gregor Mendel. This has obvious consequences for genetic counsell...

journal_title：Annals of medicine

authors： Mannens M,Alders M

更新日期：1999-02-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rapidly progressing disease characterized by an over- expression of endothelin. In addition to its potent pulmonary vasoconstrictor effects, endothelin has been shown to produce many of the aberrant changes, such as hypertrophy, fibrosis, inflammation, and neurohormonal activation ...

journal_title：Annals of medicine

authors： Clozel M

更新日期：2003-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mec...

journal_title：Annals of medicine

authors： Krishnamoorthy S,Lim SH,Lip GY

更新日期：2009-01-01 00:00:00

abstract：:Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to ...

journal_title：Annals of medicine

authors： Virkkunen M,Linnoila M

更新日期：1990-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...

journal_title：Annals of medicine

authors： Griffin BE,Xue SA

更新日期：1998-06-01 00:00:00

abstract：:This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...

journal_title：Annals of medicine

authors： Sun J,Buys N

更新日期：2015-01-01 00:00:00

abstract：:The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...

journal_title：Annals of medicine

authors： Freihorst J,Ogra PL

更新日期：2001-04-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...

journal_title：Annals of medicine

authors： Aeschbacher S,Schoen T,Dörig L,Kreuzmann R,Neuhauser C,Schmidt-Trucksäss A,Probst-Hensch NM,Risch M,Risch L,Conen D

更新日期：2017-02-01 00:00:00

abstract：:Autoantibodies directed to intracellular antigens can be detected in many systemic rheumatic diseases. In this review, we discuss the clinical significance of antinuclear antibodies (ANA) associated with systemic lupus erythematosus (SLE), Slögren's syndrome, scleroderma and polymyositis/dermatomyositis, the immunogen...

journal_title：Annals of medicine

authors： Hietarinta M,Lassila O

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (AGel amyloidosis) is an autosomal dominant disorder. Until recently, there has only been little knowledge of fatal complications of the disease and its possible impact on the patients' life span. METHODS:We identified 272 deceased patients based on patient in...

journal_title：Annals of medicine

authors： Schmidt EK,Atula S,Tanskanen M,Nikoskinen T,Notkola IL,Kiuru-Enari S

更新日期：2016-08-01 00:00:00

abstract：:The circadian rhythms of night shift workers do not usually adjust to their unusual work and sleep schedules, reducing their quality of life and producing potentially dangerous health and safety problems. This paper reviews field studies of simulated night work in which shifted light-dark cycles were constructed with ...

journal_title：Annals of medicine

authors： Eastman CI,Martin SK

更新日期：1999-04-01 00:00:00

abstract：:Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence it...

journal_title：Annals of medicine

authors： Neve A,Maruotti N,Corrado A,Cantatore FP

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Khunti K

更新日期：2018-09-01 00:00:00

abstract：:Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the ...

journal_title：Annals of medicine

authors： Svanborg C,Bergsten G,Fischer H,Frendéus B,Godaly G,Gustafsson E,Hang L,Hedlund M,Karpman D,Lundstedt AC,Samuelsson M,Samuelsson P,Svensson M,Wullt B

更新日期：2001-12-01 00:00:00

abstract：:On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...

journal_title：Annals of medicine

authors： Davignon J,Dallongeville J,Roederer G,Roy M,Fruchart JC,Kessling AM,Bouthillier D,Lussier-Cacan S

更新日期：1991-04-01 00:00:00

abstract：:Abstract The limits of traditional anticoagulants, such as heparin and warfarin, have prompted the search for new agents for prophylaxis and treatment of arterial and venous thromboembolism, including factor Xa and thrombin inhibitors. These agents can be given orally, and their most significant advantage is that no l...

journal_title：Annals of medicine

authors： Mannucci PM,Franchini M

更新日期：2011-03-01 00:00:00

abstract：:Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

journal_title：Annals of medicine

authors： Lönnberg H,Vuorio E

更新日期：1996-12-01 00:00:00

abstract：AIMS:This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile site...

journal_title：Annals of medicine

authors： Highet AR,Berry AM,Goldwater PN

更新日期：2010-01-01 00:00:00

abstract：:This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...

journal_title：Annals of medicine

authors： Keltikangas-Järvinen L,Räikkönen K,Keskivaara P,Pietikäinen M,Viikari J,Kaprio EA,Akerblom HK

更新日期：1991-02-01 00:00:00

abstract：INTRODUCTION:As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the ...

journal_title：Annals of medicine

authors： Halverson T,Alagiakrishnan K

更新日期：2020-12-01 00:00:00