Genetics of type 2 diabetes mellitus and obesity--a review.

abstract：:In three patients with attacks of acute intermittent porphyria we found markedly impaired functions of the left ventricle accompanied by ECG changes that returned to normal after administration of heme arginate or cytochrome C administration. In nine patients with other types of porphyria, and in one patient with acut...

journal_title：Annals of medicine

authors： Kordac V,Kozáková M,Martásek P

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

journal_title：Annals of medicine

authors： Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

更新日期：2009-01-01 00:00:00

abstract：:The term fibromyalgia describes a complex syndrome characterized by pain amplification, musculoskeletal discomfort, and systemic symptoms. Although its existence has been controversial, nearly all rheumatologists now accept fibromyalgia as a distinct diagnostic entity. In fact, in the United States it is the third or ...

journal_title：Annals of medicine

authors： Wallace DJ

更新日期：1997-02-01 00:00:00

abstract：:Health professionals provide care with some purpose in mind. It is reasonable to assume that they are therefore interested in observing and measuring health outcomes. In the recent past, it has become fashionable to describe health outcomes in terms of their impact on 'quality of life', a widely used term that is usua...

journal_title：Annals of medicine

authors： Kind P

更新日期：2001-07-01 00:00:00

abstract：:Although food habits arc not stable and unchanging during a person's lifetime, a base for healthy food habits can be created in early childhood. Children's food habits can be assumed to be influenced by their parents' food habits and choices. The aim of this article is to review factors influencing food choice in chil...

journal_title：Annals of medicine

authors： Hursti UK

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Ischemic stroke (IS) in a young patient is a disaster and recurrent cardiovascular events could add further impairment. Identifying patients with high risk of such events is therefore important. The prognostic relevance of ECG for this population is unknown. MATERIALS AND METHODS:A total of 690 IS patient...

journal_title：Annals of medicine

authors： Pirinen J,Putaala J,Aarnio K,Aro AL,Sinisalo J,Kaste M,Haapaniemi E,Tatlisumak T,Lehto M

更新日期：2016-11-01 00:00:00

abstract：:Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...

journal_title：Annals of medicine

authors： Huikuri HV

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) is one of the most powerful determinants of cardiovascular risk in women. This risk may differ between post-menopausal women with and without vasomotor hot flushes, possibly indicating different vascular responses to hormone therapy (HT). Thus, we compared in a clinical trial the effect o...

journal_title：Annals of medicine

authors： Tuomikoski P,Haapalahti P,Sarna S,Ylikorkala O,Mikkola TS

更新日期：2010-07-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00

abstract：:Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...

journal_title：Annals of medicine

authors： Riekkinen P Jr,Schmidt BH,van der Staay FJ

更新日期：1998-12-01 00:00:00

abstract：:The pathophysiology of psychotic and other symptoms in schizophrenia remains a mystery despite decades of research. Even though it has been suspected for many years that autoimmune mechanisms may play a role in the pathophysiology of schizophrenia, firm evidence for this hypothesis has been lacking. Our studies, over ...

journal_title：Annals of medicine

authors： Ganguli R,Brar JS,Chengappa KN,Yang ZW,Nimgaonkar VL,Rabin BS

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national ...

journal_title：Annals of medicine

authors： Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula S

更新日期：2015-01-01 00:00:00

abstract：:Study of the growth and development of cartilage and bone has been difficult because the structure of the tissues makes biological experiments hard to conduct. Recent advances in molecular biology have offered new possibilities for studying these processes. Many cartilage and bone specific cDNAs have been cloned and c...

journal_title：Annals of medicine

authors： Sandberg MM

更新日期：1991-08-01 00:00:00

abstract：:Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...

journal_title：Annals of medicine

authors： Raitakari OT,Celermajer DS

更新日期：2000-07-01 00:00:00

abstract：:Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART- (highly-active antiretroviral therapy)-associated lipodystrophy. Both obese and lipodystrophic patients, however, have an increase in the amo...

journal_title：Annals of medicine

authors： Yki-Järvinen H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：:The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been increasing for the last four decades. In this review determinants for an increased IgE synthesis are discussed on both an epidemiological and on an immunological level with special emphasis on the differentiation of the B cell to an IgE-produ...

journal_title：Annals of medicine

authors： Poulsen LK,Hummelshoj L

更新日期：2007-01-01 00:00:00

abstract：:Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...

journal_title：Annals of medicine

authors： Heikinheimo O,Kekkonen R

更新日期：1993-02-01 00:00:00

abstract：:Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...

journal_title：Annals of medicine

authors： Almasy L

更新日期：2003-01-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:Atrial fibrillation is a common cardiac arrhythmia with rapid and irregular atrial activity. Instead of uniformly contracting as one chamber, the atrial compartment fibrillates. Several studies have demonstrated that this arrhythmia contributes substantially to cardiac morbidity and mortality. The purpose of this revi...

journal_title：Annals of medicine

authors： Miyazaki S,Shah AJ,Scherr D,Haïssaguerre M

更新日期：2011-01-01 00:00:00

abstract：:Rapid prototyping (RP) is a common name for several techniques, which read in data from computer-aided design (CAD) drawings and manufacture automatically three-dimensional objects layer-by-layer according to the virtual design. The utilization of RP in tissue engineering enables the production of three-dimensional sc...

journal_title：Annals of medicine

authors： Peltola SM,Melchels FP,Grijpma DW,Kellomäki M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...

journal_title：Annals of medicine

authors： Partonen T,Treutlein J,Alpman A,Frank J,Johansson C,Depner M,Aron L,Rietschel M,Wellek S,Soronen P,Paunio T,Koch A,Chen P,Lathrop M,Adolfsson R,Persson ML,Kasper S,Schalling M,Peltonen L,Schumann G

更新日期：2007-01-01 00:00:00

abstract：:We evaluated the reliability hospital discharge register data in the assessment of acute myocardial infarction trends. In the FINMONICA study areas, trends in age standarized attack rates for the years 1983-90 were calculated independently from two sources: the nationwide Finnish hospital discharge register and the FI...

journal_title：Annals of medicine

authors： Mähönen M,Miettinen H,Pyörälä K,Molarius A,Salomaa V,Kuulasmaa K

更新日期：1995-10-01 00:00:00

abstract：:The term 'prion diseases' refers to a group of neurodegenerative disorders thought to be caused by prions, pathogenic agents with novel modes of replication and transmission. Prion diseases are characterized by long incubation periods ranging from months to years and are invariably fatal once clinical symptoms have ap...

journal_title：Annals of medicine

authors： Haltia M

更新日期：2000-10-01 00:00:00

abstract：:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...

journal_title：Annals of medicine

authors： Akerblom HK,Viikari J,Raitakari OT,Uhari M

更新日期：1999-04-01 00:00:00

abstract：:The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...

journal_title：Annals of medicine

authors： Kronborg O

更新日期：1991-10-01 00:00:00

abstract：:INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow...

journal_title：Annals of medicine

authors： Donnez J,Silber S,Andersen CY,Demeestere I,Piver P,Meirow D,Pellicer A,Dolmans MM

更新日期：2011-01-01 00:00:00

abstract：:Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...

journal_title：Annals of medicine

authors： Maassen JA,Janssen GM,'t Hart LM

更新日期：2005-01-01 00:00:00

abstract：:Hypertension is a major cardiovascular risk factor with a multifactorial pathogenesis, including genetic and environmental factors. In addition to hypothesis-driven strategies, unbiased approaches such as genomics, proteomics, and metabolomics are useful tools to help unravel the pathophysiology of hypertension and as...

journal_title：Annals of medicine

authors： Delles C,Neisius U,Carty DM

更新日期：2012-06-01 00:00:00