Towards genomic drug therapy with antisense oligonucleotides.

abstract：:Aim: This meta-analysis study aimed to compare the efficacy and safety of TEVAR versus OCSR for TBAD patients.Methods: We systematically searched PubMed, EmBase, and the Cochrane library to identify studies compared the effectiveness of TEVAR and OCSR in TBAD patients from the inception up to July 2019. The summary re...

journal_title：Annals of medicine

authors： Liu J,Xia J,Yan G,Zhang Y,Ge J,Cao L

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Commercial nucleic acid amplification tests, designed for the detection of Mycobacterium tuberculosis DNA/RNA in respiratory samples, are often applied also in nonrespiratory specimens in order to verify the diagnosis of extrapulmonary tuberculosis. AIM. To evaluate the value of the Abbott LCx Mycobacterium ...

journal_title：Annals of medicine

authors： Rantakokko-Jalava K,Marjamäki M,Marttila H,Mäkelä L,Valtonen V,Viljanen MK

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:To appraise effective predictors for COVID-19 mortality in a retrospective cohort study. METHODS:A total of 1270 COVID-19 patients, including 984 admitted in Sino French New City Branch (training and internal validation sets randomly split at 7:3 ratio) and 286 admitted in Optical Valley Branch (external va...

journal_title：Annals of medicine

authors： Guan X,Zhang B,Fu M,Li M,Yuan X,Zhu Y,Peng J,Guo H,Lu Y

更新日期：2021-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...

journal_title：Annals of medicine

authors： Griffin BE,Xue SA

更新日期：1998-06-01 00:00:00

abstract：:Exposures of human populations to pesticides and industrial pollutants, and to synthetic chemicals present in foods, beverages, and plastics, have raised concern that these substances can interfere with endogenous sex hormone function. Interference with sex hormone action can, in turn, result in a variety of developme...

journal_title：Annals of medicine

authors： Akingbemi BT,Hardy MP

更新日期：2001-09-01 00:00:00

abstract：:Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. The migration and accumulation of inflammatory cells that follow leukotriene rece...

journal_title：Annals of medicine

authors： Bäck M,Hansson GK

更新日期：2006-01-01 00:00:00

abstract：:In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...

journal_title：Annals of medicine

authors： Wilhelmi de Toledo F,Grundler F,Sirtori CR,Ruscica M

更新日期：2020-08-01 00:00:00

abstract：:Recent results from controlled trials of adjuvant tamoxifen and oophorectomy in early breast cancer are reviewed. The results of the statistical overview performed by the Early Breast Cancer Trialists Collaborative Group are summarised, and some important questions left open by this overview are discussed. These inclu...

journal_title：Annals of medicine

authors： Blomqvist CP,Elomaa I,Rissanen P

更新日期：1992-04-01 00:00:00

abstract：:Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...

journal_title：Annals of medicine

authors： Lippi G,Franchini M,Montagnana M,Favaloro EJ

更新日期：2012-08-01 00:00:00

abstract：:We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

journal_title：Annals of medicine

authors： Salonen R,Salonen JT

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...

journal_title：Annals of medicine

authors： Shivalkar B,Goovaerts I,Salgado RA,Ozsarlak O,Bosmans J,Parizel PM,Vrints CJ

更新日期：2007-01-01 00:00:00

abstract：:Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pat...

journal_title：Annals of medicine

authors： Jeffery CJ

更新日期：2003-01-01 00:00:00

abstract：:Large granular lymphocytic (LGL) leukemia is an incurable chronic disease, characterized by clonal expansion of cytotoxic T- or NK-cells in blood and bone marrow. Cytopenias (anemia, neutropenia) and autoimmune disorders such as rheumatoid arthritis are the most common clinical manifestations of LGL leukemia. Recently...

journal_title：Annals of medicine

authors： Rajala HL,Porkka K,Maciejewski JP,Loughran TP Jr,Mustjoki S

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Khunti K

更新日期：2018-09-01 00:00:00

abstract：:Hereditary tyrosinaemia type I is the most common of the diseases caused by defects in tyrosine metabolism. The underlying genetic defect is a mutation in the gene for fumarylacetate hydrolase (FAH), and more than 30 different mutations in this gene have been identified. The main clinical consequences of this defect i...

journal_title：Annals of medicine

authors： Pitkänen ST,Salo MK,Heikinheimo M

更新日期：2000-11-01 00:00:00

abstract：:The overall incidence of osteomyelitis following primary knee arthroplasty is 1-2%. Major risk factors are large prostheses, rheumatoid arthritis, postoperative wound-healing complications, skin infections, and prior deep infections. The major infecting organism is Staphylococcus aureus. Healing of the infection is to...

journal_title：Annals of medicine

authors： Bengtson S

更新日期：1993-12-01 00:00:00

abstract：AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...

journal_title：Annals of medicine

authors： Miedel C,Leander K,de Faire U,Gigante B

更新日期：2015-01-01 00:00:00

abstract：:The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

journal_title：Annals of medicine

authors： Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

更新日期：1995-02-01 00:00:00

abstract：:Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...

journal_title：Annals of medicine

authors： Huch R,Huch A

更新日期：1993-06-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00

abstract：:Abstract The limits of traditional anticoagulants, such as heparin and warfarin, have prompted the search for new agents for prophylaxis and treatment of arterial and venous thromboembolism, including factor Xa and thrombin inhibitors. These agents can be given orally, and their most significant advantage is that no l...

journal_title：Annals of medicine

authors： Mannucci PM,Franchini M

更新日期：2011-03-01 00:00:00

abstract：:Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...

journal_title：Annals of medicine

authors： Ribacka C,Pesonen S,Hemminki A

更新日期：2008-01-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that the occurrence of severe hypoglycemia during sleep may be more dangerous for cardiac arrhythmia than that in the day-time. METHODS:We performed a retrospective study between January 2006 and March 2012 to assess electrocardiograms during severe hypoglycemia in patients wi...

journal_title：Annals of medicine

authors： Tsujimoto T,Yamamoto-Honda R,Kajio H,Kishimoto M,Noto H,Hachiya R,Kimura A,Kakei M,Noda M

更新日期：2015-05-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common among the severe cardiac arrhythmias and carries a significant risk of mortality and morbidity in the general population. The most important complication is represented by development of one or more thrombi in the left atrium of the dyskinetic heart, and their successive cer...

journal_title：Annals of medicine

authors： Danese E,Montagnana M,Cervellin G,Lippi G

更新日期：2014-09-01 00:00:00

abstract：:A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...

journal_title：Annals of medicine

authors： Wald NJ,Kennard A,Smith D

更新日期：1994-02-01 00:00:00

abstract：:Radiosurgery is an increasingly popular method for treating a variety of intracranial tumours. A great deal of treatment data has been accumulated suggesting that radiosurgery may be the treatment of choice for small acoustic schwannomas. Moreover, radiosurgery promises excellent tumour control and minimal risk in the...

journal_title：Annals of medicine

authors： Friedman WA,Foote KD

更新日期：2000-02-01 00:00:00

abstract：:The pathophysiology of psychotic and other symptoms in schizophrenia remains a mystery despite decades of research. Even though it has been suspected for many years that autoimmune mechanisms may play a role in the pathophysiology of schizophrenia, firm evidence for this hypothesis has been lacking. Our studies, over ...

journal_title：Annals of medicine

authors： Ganguli R,Brar JS,Chengappa KN,Yang ZW,Nimgaonkar VL,Rabin BS

更新日期：1993-10-01 00:00:00

abstract：:During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

journal_title：Annals of medicine

authors： Borch K

更新日期：1989-08-01 00:00:00

abstract：:Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

journal_title：Annals of medicine

authors： Patton GC

更新日期：1992-08-01 00:00:00