Abstract:
BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to the variation in some cardiometabolic risk (CMR) markers. Plasma IL-1Ra levels were measured in a sample of 117 healthy non-diabetic men (age: 44.9+/-10.1 years; body mass index (BMI): 28.8+/-4.5 kg/m(2)). RESULTS:Plasma IL-1Ra levels correlated positively with BMI, waist girth, and visceral and subcutaneous AT (0.39 < or = r<0.48; P < 0.0001). Multiple regression analyses revealed that visceral AT was the best independent predictor of IL-1Ra levels, explaining 22% (P < 0.0001) of its variance. IL-1Ra (P < 0.05) was an independent predictor of several CMR markers including triglyceride and high-density lipoprotein (HDL) cholesterol levels, cholesterol/HDL cholesterol ratio, glucose and insulin concentrations in response to a 75 g oral glucose load, and fasting insulin levels, in addition to the expected contribution of visceral AT (P < 0.05). CONCLUSIONS:These results suggest that elevated IL-1Ra concentrations are influenced to a greater extent by visceral than subcutaneous adiposity and that IL-1Ra is independently related to some features of CMR beyond the known contribution of visceral adiposity.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Cartier A,Bergeron J,Poirier P,Alméras N,Tremblay A,Lemieux I,Després JPdoi
10.1080/07853890903022801subject
Has Abstractpub_date
2009-01-01 00:00:00pages
471-8issue
6eissn
0785-3890issn
1365-2060pii
911911580journal_volume
41pub_type
杂志文章abstract::Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocre...
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abstract::This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...
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更新日期:1991-12-01 00:00:00
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更新日期:1998-08-01 00:00:00
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更新日期:2018-09-01 00:00:00
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journal_title:Annals of medicine
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更新日期:2017-05-01 00:00:00
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journal_title:Annals of medicine
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更新日期:1995-06-01 00:00:00