Abstract:
:There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quantitative measurements of oxygen consumption, blood flow, energy metabolism and functioning of various neurotransmitter systems. There are several possibilities in the use of PET in drug development. It is possible to radiolabel the drug itself or to study the effect of an unlabelled drug on blood flow, energy metabolism or function of neurotransmitter systems. All these approaches have been used in drug development for neurodegenerative diseases. However, in spite of the important role of PET in pathophysiological studies of neurodegenerative diseases, thus far the versatile possibilities of PET in drug development for neurodegenerative diseases have not been fully exploited.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Rinne JOdoi
10.3109/07853899908998803subject
Has Abstractpub_date
1999-12-01 00:00:00pages
444-9issue
6eissn
0785-3890issn
1365-2060journal_volume
31pub_type
杂志文章,评审abstract::A radioimmunoassay method for endothelin was developed. Antisera raised against endothelin 1 showed significant crossreaction with endothelin 2 and 3 (45 and 13%, respectively). Considerable endothelin immunoreactivity was shown to be present in the cerebrospinal fluid of patients with a subarachnoid hemorrhage, rangi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009148932
更新日期:1990-01-01 00:00:00
abstract::Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's d...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902320322529
更新日期:2002-01-01 00:00:00
abstract::Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890802021342
更新日期:2008-01-01 00:00:00
abstract::The understanding and treatment of schizophrenia have been greatly hampered by uncertainty about etiological factors and controversy about diagnostic boundaries. Adoption studies have helped clarify both of these problems. First, the adoptees study method, the index offspring of adopting-away schizophrenic biological ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899409147896
更新日期:1994-08-01 00:00:00
abstract::The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribut...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999109
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome. METHODS:This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1015601
更新日期:2015-05-01 00:00:00
abstract::Mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) are autoimmune diseases with a genetic background, and it is reasonable to suggest that aberrations in T cell receptor (TCR) genes could contribute to these diseases, as they play an important role in immune regulation. We studied TCR beta-c...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899409147342
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND AIMS:A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ke...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802032711
更新日期:2008-01-01 00:00:00
abstract::MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their le...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2014.958196
更新日期:2014-12-01 00:00:00
abstract::Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-te...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899708999362
更新日期:1997-10-01 00:00:00
abstract::Circadian rhythms are a cardinal feature of living organisms. The stereotypical organization of homeostatic, endocrine and behavioural variables around the 24-hour cycle constitutes one of the most conserved attributes among species. It is now well established that circadian rhythmicity is not a learned behaviour, but...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899709002457
更新日期:1995-08-01 00:00:00
abstract::Caveolae are vesicular organelles (50-100-nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890410018899
更新日期:2004-01-01 00:00:00
abstract::The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899109148086
更新日期:1991-10-01 00:00:00
abstract::Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the ...
journal_title:Annals of medicine
pub_type: 社论
doi:10.3109/07853890109002101
更新日期:2001-12-01 00:00:00
abstract:AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1100321
更新日期:2015-01-01 00:00:00
abstract::Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic aut...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310005966
更新日期:2003-01-01 00:00:00
abstract::Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899309147861
更新日期:1993-02-01 00:00:00
abstract::The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002074
更新日期:2001-04-01 00:00:00
abstract::Steroids diffuse through polysiloxone at a constant rate, and steroids placed in the vagina rapidly pass through the vaginal epithelium into the circulation. Combining these principles led to the development of contraceptive vaginal rings (CVR) consisting of various progestins, with and without oestrogen, placed in fl...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899309164167
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2016.1267869
更新日期:2017-05-01 00:00:00
abstract::One of the major discoveries in modern genetics is the phenomenon of genomic, or parental, imprinting. The parent-of-origin effects seen after transmission of an imprinted gene from parents to their children do not follow the genetic rules postulated by Gregor Mendel. This has obvious consequences for genetic counsell...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899909019258
更新日期:1999-02-01 00:00:00
abstract::Nitric oxide (NO), derived from the vascular endothelium and other cells of the cardiovascular system, has important roles in physiological regulation of blood flow and may have pathophysiological functions in cardiovascular disease. The mechanisms involved in NO-induced vasodilatation and cytotoxicity are briefly rev...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899509002593
更新日期:1995-06-01 00:00:00
abstract::Epstein-Barr virus (EBV) expresses genes that stimulate cells to divide in culture. This property, coupled with the close association of the virus with numerous malignancies, has prompted its designation as a human DNA tumour virus. Before human herpesvirus 8 (HHV-8, alternatively KS virus) was discovered, EBV was uni...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809005852
更新日期:1998-06-01 00:00:00
abstract::Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109148098
更新日期:1991-12-01 00:00:00
abstract::Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899708999355
更新日期:1997-08-01 00:00:00
abstract::The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899509031937
更新日期:1995-02-01 00:00:00
abstract::Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890510007188
更新日期:2005-01-01 00:00:00
abstract:AIM:As the capability of human mesenchymal stem cells (hMSC) to engraft, differentiate and improve myocardial function cannot be studied in humans, exploration was performed in a xenomodel. METHODS:The rats were divided into three groups depending on the type of rats used (Rowett nude (RNU) or Fischer rats +/- immunos...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890500422982
更新日期:2006-01-01 00:00:00
abstract::Radiosurgery is an increasingly popular method for treating a variety of intracranial tumours. A great deal of treatment data has been accumulated suggesting that radiosurgery may be the treatment of choice for small acoustic schwannomas. Moreover, radiosurgery promises excellent tumour control and minimal risk in the...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995912
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890600673260
更新日期:2006-01-01 00:00:00