Insight into the genetic epidemiology of coronary heart disease.


:The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribute to CHD appears possible; this may considerably improve our understanding of the aetiology and mechanisms of this disease. Furthermore, simultaneous analysis of several predisposing alleles may help to identify high-risk individuals.


Ann Med


Annals of medicine


Cambien F




Has Abstract


1996-10-01 00:00:00












  • Carotid atherosclerosis in relation to systolic and diastolic blood pressure: Kuopio Ischaemic Heart Disease Risk Factor Study.

    abstract::We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Salonen R,Salonen JT

    更新日期:1991-02-01 00:00:00

  • The future of psychiatric genetics.

    abstract::Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing comple...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: van den Bree MB,Owen MJ

    更新日期:2003-01-01 00:00:00

  • Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.

    abstract::Large granular lymphocytic (LGL) leukemia is an incurable chronic disease, characterized by clonal expansion of cytotoxic T- or NK-cells in blood and bone marrow. Cytopenias (anemia, neutropenia) and autoimmune disorders such as rheumatoid arthritis are the most common clinical manifestations of LGL leukemia. Recently...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Rajala HL,Porkka K,Maciejewski JP,Loughran TP Jr,Mustjoki S

    更新日期:2014-05-01 00:00:00

  • Chronic helminth infections modulate allergen-specific immune responses: Protection against development of allergic disorders?

    abstract::Inflammatory diseases are on the rise in westernized countries, but also in urbanized areas of developing countries. A number of studies have now demonstrated a negative association between helminth infections and inflammatory diseases, such as allergy, suggesting a potential role for helminth-induced immune responses...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Smits HH,Yazdanbakhsh M

    更新日期:2007-01-01 00:00:00

  • Towards genomic drug therapy with antisense oligonucleotides.

    abstract::Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Lönnberg H,Vuorio E

    更新日期:1996-12-01 00:00:00

  • Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity.

    abstract::Due to its varied and variable phenotypes, Andersen-Tawil syndrome (ATS) holds a unique place in the field of channelopathies. Patients with ATS typically present with the triad of periodic paralysis, cardiac arrhythmias, and developmental dysmorphisms. Although penetrance of ATS is high, disease expression and severi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Donaldson MR,Yoon G,Fu YH,Ptacek LJ

    更新日期:2004-01-01 00:00:00

  • Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.

    abstract::Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closel...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Johansson B,Mertens F,Mitelman F

    更新日期:2004-01-01 00:00:00

  • Delivering genetic screening to the community.

    abstract::Concern is often expressed that, in the future, screening for genetic risk will become too widespread. Haemoglobin disorders (the thalassaemias and sickle cell disorders) offer an excellent model for genetic screening, because they are common and severe. They are recessively inherited. Carriers can be detected by conv...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Modell B

    更新日期:1997-12-01 00:00:00

  • Disordered proteins in dementia.

    abstract::Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's d...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Ingelsson M,Hyman BT

    更新日期:2002-01-01 00:00:00

  • The risk-map of Europe. WHO ERICA Research Group.

    abstract::In Europe around 1970 there were only a few small and often poorly known epidemiological studies on risk factors and the incidence of coronary heart disease. In order to enhance the utilization of the information contained in them, the Medical Clinic in Heidelberg offered uniform data analysis to qualifying contributi...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Lamm G

    更新日期:1989-06-01 00:00:00

  • Sex, age, and time to cardioversion. Risk factors for cardioversion of acute atrial fibrillation from the FinCV study.

    abstract:BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

    更新日期:2017-05-01 00:00:00

  • Ten-year experience with transcatheter and surgical aortic valve replacement in Finland.

    abstract::Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...

    journal_title:Annals of medicine

    pub_type: 临床试验,杂志文章


    authors: Mäkikallio T,Jalava MP,Husso A,Virtanen M,Laakso T,Ahvenvaara T,Tauriainen T,Maaranen P,Kinnunen EM,Dahlbacka S,Jaakkola J,Airaksinen J,Anttila V,Savontaus M,Laine M,Juvonen T,Valtola A,Raivio P,Eskola M,Niemelä M,

    更新日期:2019-01-01 00:00:00

  • Drug development for neurodegenerative diseases: role of PET.

    abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Rinne JO

    更新日期:1999-12-01 00:00:00

  • Molecular and clinical aspects of inherited cardiomyopathies.

    abstract::Hypertrophic cardiomyopathy (HCM) is phenotypically and genotypically a heterogeneous disease. Since 1989, four chromosomal loci have been identified for HCM and the genes residing on three of these have been identified as beta-myosin heavy chain (beta-MHC), cardiac troponin-T and alpha-tropomyosin. These genes code f...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Durand JB,Abchee AB,Roberts R

    更新日期:1995-06-01 00:00:00

  • Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS).

    abstract:INTRODUCTION:Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS:A total of 2003 individuals from the Helsinki Birth C...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Eriksson JG,Sandboge S,Salonen M,Kajantie E,Osmond C

    更新日期:2015-03-01 00:00:00

  • The role of genetic predisposition to type I (insulin-dependent) diabetes mellitus.

    abstract::The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

    更新日期:1991-10-01 00:00:00

  • Monitoring of cardiovascular disease and risk factor trends: experiences from the WHO/MONICA project.

    abstract::The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Gutzwiller F

    更新日期:1994-02-01 00:00:00

  • Pathophysiology of salt sensitivity hypertension.

    abstract::Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Ando K,Fujita T

    更新日期:2012-06-01 00:00:00

  • Molecular genetics of anxiety in mice and men.

    abstract::Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Hovatta I,Barlow C

    更新日期:2008-01-01 00:00:00

  • Field cancerization: are multiple primary cancers monoclonal or polyclonal?

    abstract::Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...

    journal_title:Annals of medicine

    pub_type: 社论,评审


    authors: Carey TE

    更新日期:1996-06-01 00:00:00

  • Familial hypertrophic cardiomyopathy: a paradigm of the cardiac hypertrophic response to injury.

    abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in sarcomeric proteins. It is characterized by left ventricular hypertrophy in the absence of an increased external load, and myofibrillar disarray. While hypertrophy is a common cardiac response to injury, disarray is the pathologi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Marian AJ,Roberts R

    更新日期:1998-08-01 00:00:00

  • Effectiveness of inhaled corticosteroids in the treatment of acute asthma in children in the emergency department: a meta-analysis.

    abstract:OBJECTIVES:This meta-analysis aimed to compare the treatment of an acute asthma attack in children in the emergency department (ED) with inhaled corticosteroids (ICS) versus placebo or oral systemic corticosteroids (SC) as assessed by the hospital admission rates. METHODS:After searching Medline, Cochrane, EMBASE, and...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析


    authors: Su XM,Yu N,Kong LF,Kang J

    更新日期:2014-02-01 00:00:00

  • Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.

    abstract:BACKGROUND:Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS:This is a retrospective mu...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Carrasco-Sánchez FJ,López-Carmona MD,Martínez-Marcos FJ,Pérez-Belmonte LM,Hidalgo-Jiménez A,Buonaiuto V,Suárez Fernández C,Freire Castro SJ,Luordo D,Pesqueira Fontan PM,Blázquez Encinar JC,Magallanes Gamboa JO,de la Peña Fernánde

    更新日期:2021-12-01 00:00:00

  • Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit?

    abstract::Pulmonary arterial hypertension is a rapidly progressing disease characterized by an over- expression of endothelin. In addition to its potent pulmonary vasoconstrictor effects, endothelin has been shown to produce many of the aberrant changes, such as hypertrophy, fibrosis, inflammation, and neurohormonal activation ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Clozel M

    更新日期:2003-01-01 00:00:00

  • Decreased androgen levels and obesity in men.

    abstract::Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Vermeulen A

    更新日期:1996-02-01 00:00:00

  • Benchmarking Controlled Trial--a novel concept covering all observational effectiveness studies.

    abstract::The Benchmarking Controlled Trial (BCT) is a novel concept which covers all observational studies aiming to assess effectiveness. BCTs provide evidence of the comparative effectiveness between health service providers, and of effectiveness due to particular features of the health and social care systems. BCTs compleme...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Malmivaara A

    更新日期:2015-06-01 00:00:00

  • Atherosclerosis and innate immune signaling.

    abstract::Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Laberge MA,Moore KJ,Freeman MW

    更新日期:2005-01-01 00:00:00

  • Genetics of type 2 diabetes mellitus and obesity--a review.

    abstract::Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Jafar-Mohammadi B,McCarthy MI

    更新日期:2008-01-01 00:00:00

  • Serum trace element concentrations and iron metabolism in allogeneic bone marrow transplant recipients.

    abstract::Serum trace element concentrations, parameters of iron metabolism and serum protein concentrations were investigated in thirteen adult recipients of bone-marrow transplants receiving total parenteral nutrition. Six of the patients died during the four weeks follow-up. Serum zinc concentrations were initially low but i...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Antila HM,Salo MS,Kirvelä O,Näntö V,Rajamäki A,Toivanen A

    更新日期:1992-02-01 00:00:00

  • Eating disorders: antecedents, evolution and course.

    abstract::Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Patton GC

    更新日期:1992-08-01 00:00:00