Intracoronary radiotherapy for prevention of restenosis after percutaneous coronary interventions.

abstract：:Congruence of evidence from all medical research methodologies has established the major causal influences in cardiovascular disease. Causation thus established, epidemiological observations are the best available evidence on which to base estimates of the potential of preventive strategies. From population comparison...

journal_title：Annals of medicine

authors： Blackburn H

更新日期：1989-06-01 00:00:00

abstract：:Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...

journal_title：Annals of medicine

authors： Almasy L

更新日期：2003-01-01 00:00:00

abstract：:Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine...

journal_title：Annals of medicine

authors： Nammas W,Koistinen J,Paana T,Karjalainen PP

更新日期：2017-08-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in sper...

journal_title：Annals of medicine

authors： Tapanainen JS,Aittomäki K,Huhtaniemi IT

更新日期：1997-08-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their le...

journal_title：Annals of medicine

authors： Tay HL,Plank M,Collison A,Mattes J,Kumar RK,Foster PS

更新日期：2014-12-01 00:00:00

abstract：:Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...

journal_title：Annals of medicine

authors： Lippi G,Franchini M,Montagnana M,Favaloro EJ

更新日期：2012-08-01 00:00:00

abstract：:Depression, among other mood disorders, represents one of the most common health problems worldwide, with steadily increasing incidence and major socio-economic consequences. However, since the knowledge about the underlying pathophysiological principles is still very scanty, depression and other mood disorders are cu...

journal_title：Annals of medicine

authors： Pollak DD,Rey CE,Monje FJ

更新日期：2010-05-06 00:00:00

abstract：:Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...

journal_title：Annals of medicine

authors： Mäkikallio T,Jalava MP,Husso A,Virtanen M,Laakso T,Ahvenvaara T,Tauriainen T,Maaranen P,Kinnunen EM,Dahlbacka S,Jaakkola J,Airaksinen J,Anttila V,Savontaus M,Laine M,Juvonen T,Valtola A,Raivio P,Eskola M,Niemelä M,

更新日期：2019-01-01 00:00:00

abstract：:Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...

journal_title：Annals of medicine

authors： Rivera R

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE AND METHODS:The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS:A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic re...

journal_title：Annals of medicine

authors： Äijälä M,Ronkainen J,Huusko T,Malo E,Savolainen ER,Savolainen MJ,Salonurmi T,Bloigu R,Kesäniemi YA,Ukkola O

更新日期：2015-01-01 00:00:00

abstract：:Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...

journal_title：Annals of medicine

authors： Johansen K,Theorell H,Karlsson J,Diamant B,Folkers K

更新日期：1991-12-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：:The purpose of this study was to test the applicability of exercise echocardiography in the diagnosis of coronary artery disease. The results were compared to findings of coronary angiography. 118 patients, 100 males and 18 females, who were all referred to coronary angiography for suspected ischaemic heart disease, u...

journal_title：Annals of medicine

authors： Luotolahti M,Saraste M,Hartiala J

更新日期：1996-02-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:Certain bacterial infections have been demonstrated to be causative of reactive arthritis. The most common bacterial trigger of reactive arthritis is Chlamydia trachomatis. Chlamydia pneumoniae is another known cause, albeit far less frequently. Although Chlamydia-induced reactive arthritis will often spontaneously re...

journal_title：Annals of medicine

authors： Carter JD,Inman RD,Whittum-Hudson J,Hudson AP

更新日期：2012-12-01 00:00:00

abstract：:Study of the growth and development of cartilage and bone has been difficult because the structure of the tissues makes biological experiments hard to conduct. Recent advances in molecular biology have offered new possibilities for studying these processes. Many cartilage and bone specific cDNAs have been cloned and c...

journal_title：Annals of medicine

authors： Sandberg MM

更新日期：1991-08-01 00:00:00

abstract：:In the Netherlands there are about 9700 explicit requests for euthanasia or physician-assisted suicide (EAS) each year, of which approximately 3600 are granted. Other countries have criticized the Dutch policy concerning EAS. It has been suggested that palliative care in the Netherlands is not adequate and that euthan...

journal_title：Annals of medicine

authors： Swarte NB,Heintz AP

更新日期：1999-12-01 00:00:00

abstract：:The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecul...

journal_title：Annals of medicine

authors： Curtis AM,Fitzgerald GA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

journal_title：Annals of medicine

authors： Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

更新日期：2009-01-01 00:00:00

abstract：:The processes of glycation and oxidation play a significant role in the acceleration of atherosclerosis in diabetes mellitus. Glycation is thought not only to increase the susceptibility of low-density lipoprotein (LDL) to oxidation but also to enhance the propensity of vessel wall structural proteins to bind extravas...

journal_title：Annals of medicine

authors： Lopes-Virella MF,Virella G

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...

journal_title：Annals of medicine

authors： Shivalkar B,Goovaerts I,Salgado RA,Ozsarlak O,Bosmans J,Parizel PM,Vrints CJ

更新日期：2007-01-01 00:00:00

abstract：:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...

journal_title：Annals of medicine

authors： Akerblom HK,Viikari J,Raitakari OT,Uhari M

更新日期：1999-04-01 00:00:00

abstract：:Copper is a trace element necessary for the normal function of several important enzymes but copper homeostasis is still poorly understood. In recent years remarkable progress has been made in this field following the isolation of the gene defective in Menkes disease. Menkes disease and occipital horn syndrome are X-l...

journal_title：Annals of medicine

authors： Tümer Z,Horn N

更新日期：1996-04-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00

abstract：:Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...

journal_title：Annals of medicine

authors： Tuomilehto-Wolf E,Tuomilehto J,Hitman GA

更新日期：1992-12-01 00:00:00

abstract：:The metabolic syndrome, which is very common in the general population, is defined by the clustering of several classic cardiovascular risk factors, such as type 2 diabetes, hypertension, high triglycerides and low high-density lipoprotein cholesterol (HDL). Central obesity and insulin resistance, which are the two un...

journal_title：Annals of medicine

authors： Bonora E

更新日期：2006-01-01 00:00:00

abstract：:Steroids diffuse through polysiloxone at a constant rate, and steroids placed in the vagina rapidly pass through the vaginal epithelium into the circulation. Combining these principles led to the development of contraceptive vaginal rings (CVR) consisting of various progestins, with and without oestrogen, placed in fl...

journal_title：Annals of medicine

authors： Mishell DR Jr

更新日期：1993-04-01 00:00:00

abstract：:Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

journal_title：Annals of medicine

authors： Patton GC

更新日期：1992-08-01 00:00:00

abstract：:The human airways are protected from invading micro-organisms by the highly efficient innate immune system. Antimicrobial peptides that are produced by inflammatory cells and airway epithelial cells are key elements in this innate immune system. A major subgroup of the antimicrobial peptides is the family of defensins...

journal_title：Annals of medicine

authors： Aarbiou J,Rabe KF,Hiemstra PS

更新日期：2002-01-01 00:00:00