Abstract：
:Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the prevention of sudden death. Analysis of heart rate variability (HRV) from ambulatory electrocadiographic recordings can identify the patients at increased risk for arrhythmic death after an acute myocardial infarction. Despite the epidemiological evidence of an association between low HRV and sudden arrhythmic death, the pathophysiological link of this association has not been completely understood. An important approach to understand this association is to investigate the heart rate dynamics before the spontaneous onset of life-threatening arrhythmias. Analysis of heart rate behaviour preceding the spontaneous onset of ventricular tachyarrhythmias has shown that overall HRV is impaired in patients who develop spontaneous ventricular tachycardia during the Holter recording. Recently, quantitative analysis of Poincaré plots of successive R-R intervals has shown that reduced long-term R-R interval variability, associated with episodes of beat-to-beat sinus alternans, is a specific sign of a propensity for spontaneous onset of ventricular tachycardia. These studies suggest that abnormal heart rate behaviour reflects an electrical instability favoring the onset of life-threatening arrhythmia and provide evidence that altered neurohumoral or autonomic regulation is an important trigger mechanism for the spontaneous onset of life-threatening arrhythmia. Future research in larger patient populations will reveal whether analysis of dynamic behaviour of cardiac electrical signals will give new insights into the mechanisms of life-threatening arrhythmias and help in the development of new therapeutic options for the prevention of sudden arrhythmic death.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Huikuri HVdoi
10.3109/07853899708999355subject
Has Abstractpub_date
1997-08-01 00:00:00pages
321-5issue
4eissn
0785-3890issn
1365-2060journal_volume
29pub_type
杂志文章,评审abstract：INTRODUCTION:The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome. METHODS:This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. ...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853890.2015.1015601
更新日期：2015-05-01 00:00:00
abstract：AIM:As the capability of human mesenchymal stem cells (hMSC) to engraft, differentiate and improve myocardial function cannot be studied in humans, exploration was performed in a xenomodel. METHODS:The rats were divided into three groups depending on the type of rats used (Rowett nude (RNU) or Fischer rats +/- immunos...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.1080/07853890500422982
更新日期：2006-01-01 00:00:00
abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853899609033128
更新日期：1996-06-01 00:00:00
abstract：:The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribut...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853899608999109
更新日期：1996-10-01 00:00:00
abstract：:Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by m...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853890.2010.547212
更新日期：2011-08-01 00:00:00
abstract：:The circadian clock generates oscillations in physiology and behavior, known as circadian rhythms. Links between the circadian clock genes Periods, Bmal1, and Cryptochromes and aging and cancer are emerging. Circadian clock gene expression is changed in human pathologies, and transgenic mice with mutations in clock ge...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853890.2010.499134
更新日期：2010-09-01 00:00:00
abstract：:Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853899209149955
更新日期：1992-08-01 00:00:00
abstract：:Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the ...
journal_title：Annals of medicine
pub_type： 社论
doi：10.3109/07853890109002101
更新日期：2001-12-01 00:00:00
abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853899809002485
更新日期：1998-10-01 00:00:00
abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853899009147262
更新日期：1990-06-01 00:00:00
abstract：:The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853890008995949
更新日期：2000-09-01 00:00:00
abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.1080/07853890802552437
更新日期：2009-01-01 00:00:00
abstract：:This is a brief overview of the cytokine network within juvenile chronic arthritis, introducing the concept of the production of T-helper 1 (TH-1) or TH2-cell differentiation as a result of cytokine production, as well as the concept of the balance between pro- and anti-inflammatory cytokines. The balance of TH1 and T...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853899709113701
更新日期：1997-04-01 00:00:00
abstract：:More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853890009002033
更新日期：2000-12-01 00:00:00
abstract：INTRODUCTION:Obesity has reached epidemic proportions worldwide. Maternal obesity has consequences for the offspring's later health. Only few studies have focused upon the long-term consequences of maternal obesity on the offspring's later health. METHODS:A total of 13,345 men and women born in Helsinki during 1934-44...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853890.2014.919728
更新日期：2014-09-01 00:00:00
abstract：:This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...
journal_title：Annals of medicine
pub_type： 杂志文章,meta分析,评审
doi：10.3109/07853890.2015.1071872
更新日期：2015-01-01 00:00:00
abstract：:Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting w...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853890.2016.1168936
更新日期：2016-01-01 00:00:00
abstract：:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocre...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.1080/07853890500372047
更新日期：2005-01-01 00:00:00
abstract：:Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853890.2011.565065
更新日期：2011-08-01 00:00:00
abstract：:Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult popul...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.1080/07853890.2016.1271957
更新日期：2017-05-01 00:00:00
abstract：:The question why low-density lipoprotein (LDL) stranded in the subendothelium of arteries should acquire the proinflammatory properties that initiate and sustain atherogenesis has puzzled researchers for decades. The most popular concept contends that oxidative processes are crucial because oxidized LDL (ox-LDL) produ...
journal_title：Annals of medicine
pub_type： 社论
doi：10.3109/07853899809002596
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Mortality from coronary heart disease (CHD) has been constantly higher in eastern late settlement regions compared to western early settlements in Finland, unrelated to classical risk factors. In line with this, eastern birthplace was an age-dependent predictor of severe coronary atherosclerosis and pre-hosp...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853890.2012.727021
更新日期：2013-05-01 00:00:00
abstract：:Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.1080/07853890802021342
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:This meta-analysis aimed to compare the treatment of an acute asthma attack in children in the emergency department (ED) with inhaled corticosteroids (ICS) versus placebo or oral systemic corticosteroids (SC) as assessed by the hospital admission rates. METHODS:After searching Medline, Cochrane, EMBASE, and...
journal_title：Annals of medicine
pub_type： 杂志文章,meta分析
doi：10.3109/07853890.2013.859855
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To assess the accuracy of multislice cardiac computed tomography (MSCT) for detection of significant coronary artery disease (CAD) in middle-aged symptomatic women. METHODS:We included 70 women (51+/-8 years) with complaints of chest pain or dyspnea, and an abnormal maximum exercise electrocardiogram (ECG) (...
journal_title：Annals of medicine
pub_type： 临床试验,杂志文章
doi：10.1080/07853890701233832
更新日期：2007-01-01 00:00:00
abstract：:The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853898909149176
更新日期：1989-02-01 00:00:00
abstract：:We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853899109147926
更新日期：1991-02-01 00:00:00
abstract：:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：
更新日期：1999-04-01 00:00:00
abstract：:Circadian rhythms are a cardinal feature of living organisms. The stereotypical organization of homeostatic, endocrine and behavioural variables around the 24-hour cycle constitutes one of the most conserved attributes among species. It is now well established that circadian rhythmicity is not a learned behaviour, but...
journal_title：Annals of medicine
pub_type： 杂志文章,评审
doi：10.3109/07853899709002457
更新日期：1995-08-01 00:00:00
abstract：:Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...
journal_title：Annals of medicine
pub_type： 杂志文章
doi：10.3109/07853899209147839
更新日期：1992-10-01 00:00:00
