Abstract:
:This is a brief overview of the cytokine network within juvenile chronic arthritis, introducing the concept of the production of T-helper 1 (TH-1) or TH2-cell differentiation as a result of cytokine production, as well as the concept of the balance between pro- and anti-inflammatory cytokines. The balance of TH1 and TH2 cells of pro- and anti-inflammatory cytokines could be altered as a result of genetic differences in the expression levels of a number of key cytokines and may be the critical events leading to chronic inflammation. Finally, the importance of identifying molecular targets for intervention therapy to change the balance of the cytokine network is proposed.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Woo Pdoi
10.3109/07853899709113701subject
Has Abstractpub_date
1997-04-01 00:00:00pages
145-7issue
2eissn
0785-3890issn
1365-2060journal_volume
29pub_type
杂志文章,评审abstract::Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. The migration and accumulation of inflammatory cells that follow leukotriene rece...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890600982737
更新日期:2006-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a genetically complex disorder associated with multiple genetic defects either mutational or of susceptibility. Current AD genetics does not explain in full the etiopathogenesis of AD, suggesting that environmental factors and/or epigenetic phenomena may also contribute to AD pathology and ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902320772115
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802498961
更新日期:2009-01-01 00:00:00
abstract::Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...
journal_title:Annals of medicine
pub_type: 社论,评审
doi:10.3109/07853899609033118
更新日期:1996-06-01 00:00:00
abstract::Depression, among other mood disorders, represents one of the most common health problems worldwide, with steadily increasing incidence and major socio-economic consequences. However, since the knowledge about the underlying pathophysiological principles is still very scanty, depression and other mood disorders are cu...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853891003769957
更新日期:2010-05-06 00:00:00
abstract::Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2018.1490025
更新日期:2018-08-01 00:00:00
abstract::A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009147262
更新日期:1990-06-01 00:00:00
abstract::The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:Inflammation is an important contributor to the development of chronic diseases. We examined whether a healthy Nordic diet, also called the Baltic Sea diet, associates with lower concentrations of inflammatory markers. METHODS:We used two independent cross-sectional studies: the DILGOM study including Fin...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2013.870020
更新日期:2014-03-01 00:00:00
abstract::The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890008995949
更新日期:2000-09-01 00:00:00
abstract::INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2010.546807
更新日期:2011-01-01 00:00:00
abstract::The goals of this chapter are to provide a brief review of the biology of the protein C pathway and some of the features of the pathway that make it uniquely positioned to control microvascular coagulation and control the acute inflammatory response. Activated protein C works as an antithrombotic agent by inactivating...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902321117823
更新日期:2002-01-01 00:00:00
abstract::Autoantibodies directed to intracellular antigens can be detected in many systemic rheumatic diseases. In this review, we discuss the clinical significance of antinuclear antibodies (ANA) associated with systemic lupus erythematosus (SLE), Slögren's syndrome, scleroderma and polymyositis/dermatomyositis, the immunogen...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999081
更新日期:1996-08-01 00:00:00
abstract::The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile acids, determined by a genetic predisposition interacting with environmental factors. The total amount of oestrogens and progesterone circulating in the blood or...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890009011758
更新日期:2000-03-01 00:00:00
abstract::Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209147839
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE AND METHODS:The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS:A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic re...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1091088
更新日期:2015-01-01 00:00:00
abstract::Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890108995963
更新日期:2001-11-01 00:00:00
abstract::In the past few years diabetes has become the leading cause of end-stage renal disease in all Western countries. A correlation between blood pressure and rate of progression in diabetic nephropathy was noted very early, and increased local activity of the renin angiotensin system was identified as a major pathophysiol...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902321117715
更新日期:2002-01-01 00:00:00
abstract::A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899409147323
更新日期:1994-02-01 00:00:00
abstract::In the last three decades the incidence of metabolic syndrome (MetS) has been growing worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). In children and adolescents such epidemics are particularly worrisome, since the metabolic consequences in adulthoo...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2010.547869
更新日期:2012-02-01 00:00:00
abstract::Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999068
更新日期:1996-02-01 00:00:00
abstract::Abstract The limits of traditional anticoagulants, such as heparin and warfarin, have prompted the search for new agents for prophylaxis and treatment of arterial and venous thromboembolism, including factor Xa and thrombin inhibitors. These agents can be given orally, and their most significant advantage is that no l...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2010.539250
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome. METHODS:This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1015601
更新日期:2015-05-01 00:00:00
abstract::A radioimmunoassay method for endothelin was developed. Antisera raised against endothelin 1 showed significant crossreaction with endothelin 2 and 3 (45 and 13%, respectively). Considerable endothelin immunoreactivity was shown to be present in the cerebrospinal fluid of patients with a subarachnoid hemorrhage, rangi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009148932
更新日期:1990-01-01 00:00:00
abstract::Diabetes in childhood and adolescence is a difficult, lifelong, evolving disorder. Insulin treatment is essential for the establishment and maintenance of optimal metabolic control but it is only part of a comprehensive child-focused management strategy which must be initiated at the time of diagnosis. Attention must ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899708999372
更新日期:1997-10-01 00:00:00
abstract::The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; th...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2017.1392595
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS:A total of 2003 individuals from the Helsinki Birth C...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1004360
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Blood pressure (BP) is one of the most powerful determinants of cardiovascular risk in women. This risk may differ between post-menopausal women with and without vasomotor hot flushes, possibly indicating different vascular responses to hormone therapy (HT). Thus, we compared in a clinical trial the effect o...
journal_title:Annals of medicine
pub_type: 杂志文章,随机对照试验
doi:10.3109/07853891003796760
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Several studies have suggested that the occurrence of severe hypoglycemia during sleep may be more dangerous for cardiac arrhythmia than that in the day-time. METHODS:We performed a retrospective study between January 2006 and March 2012 to assess electrocardiograms during severe hypoglycemia in patients wi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1017528
更新日期:2015-05-01 00:00:00
abstract::One of the major discoveries in modern genetics is the phenomenon of genomic, or parental, imprinting. The parent-of-origin effects seen after transmission of an imprinted gene from parents to their children do not follow the genetic rules postulated by Gregor Mendel. This has obvious consequences for genetic counsell...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899909019258
更新日期:1999-02-01 00:00:00