Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction--Helsinki Sudden Death Study.

abstract：:Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic con...

journal_title：Annals of medicine

authors： Vetter V,Denizer G,Friedland LR,Krishnan J,Shapiro M

更新日期：2018-03-01 00:00:00

abstract：:Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...

journal_title：Annals of medicine

authors： Huikuri HV

更新日期：1997-08-01 00:00:00

abstract：:The effect of ovarian carcinoma on the circulating concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) was studied in 17 patients before and during treatment. ICTP is a complex peptide released from type I collagen, which is the main organic component of bone matrix but also induced...

journal_title：Annals of medicine

authors： Santala M,Risteli L,Puistola U,Risteli J,Kauppila A

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...

journal_title：Annals of medicine

authors： Baldassarre D,De Jong A,Amato M,Werba JP,Castelnuovo S,Frigerio B,Veglia F,Tremoli E,Sirtori CR

更新日期：2008-01-01 00:00:00

abstract：:During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

journal_title：Annals of medicine

authors： Borch K

更新日期：1989-08-01 00:00:00

abstract：:Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing comple...

journal_title：Annals of medicine

authors： van den Bree MB,Owen MJ

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Khunti K

更新日期：2018-09-01 00:00:00

abstract：IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...

journal_title：Annals of medicine

authors： Mamza J,Mehta R,Donnelly R,Idris I

更新日期：2016-01-01 00:00:00

abstract：:Immunocytochemical studies using antibodies to cytoskeletal proteins have provided conflicting data on the components of paired helical filaments (PHF), due solely to immunological cross-reactivities. To avoid such ambiguity, we developed a protein chemical approach to the identification of the PHF components. After t...

journal_title：Annals of medicine

authors： Ihara Y,Kondo J

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Commercial nucleic acid amplification tests, designed for the detection of Mycobacterium tuberculosis DNA/RNA in respiratory samples, are often applied also in nonrespiratory specimens in order to verify the diagnosis of extrapulmonary tuberculosis. AIM. To evaluate the value of the Abbott LCx Mycobacterium ...

journal_title：Annals of medicine

authors： Rantakokko-Jalava K,Marjamäki M,Marttila H,Mäkelä L,Valtonen V,Viljanen MK

更新日期：2001-02-01 00:00:00

abstract：:In the last three decades the incidence of metabolic syndrome (MetS) has been growing worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). In children and adolescents such epidemics are particularly worrisome, since the metabolic consequences in adulthoo...

journal_title：Annals of medicine

authors： Alisi A,Cianfarani S,Manco M,Agostoni C,Nobili V

更新日期：2012-02-01 00:00:00

abstract：:This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...

journal_title：Annals of medicine

authors： Sun J,Buys N

更新日期：2015-01-01 00:00:00

abstract：:Naltrexone is the first safe and effective pharmaceutical adjunct for use in the treatment of alcohol abuse. Theoretically it could be effective also as a means for terminating methadone maintenance and in the treatment of other forms of substance abuse. Two general types of protocols have been used with naltrexone. O...

journal_title：Annals of medicine

authors： Sinclair JD

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...

journal_title：Annals of medicine

authors： Korkeila P,Ylitalo A,Koistinen J,Airaksinen KE

更新日期：2009-01-01 00:00:00

abstract：:The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...

journal_title：Annals of medicine

authors： Gutzwiller F

更新日期：1994-02-01 00:00:00

abstract：:In the past few years diabetes has become the leading cause of end-stage renal disease in all Western countries. A correlation between blood pressure and rate of progression in diabetic nephropathy was noted very early, and increased local activity of the renin angiotensin system was identified as a major pathophysiol...

journal_title：Annals of medicine

authors： Eberhard R,Dikow R

更新日期：2002-01-01 00:00:00

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：:Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We ...

journal_title：Annals of medicine

authors： Pérez-Belmonte LM,Osuna-Sánchez J,Millán-Gómez M,López-Carmona MD,Gómez-Doblas JJ,Cobos-Palacios L,Sanz-Cánovas J,Barbancho MA,Lara JP,Jiménez-Navarro M,Bernal-López MR,Gómez-Huelgas R

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome. METHODS:This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. ...

journal_title：Annals of medicine

authors： Ramos AR,Wallace DM,Pandi-Perumal SR,Williams NJ,Castor C,Sevick MA,Mcfarlane SI,Jean-Louis G

更新日期：2015-05-01 00:00:00

abstract：:Cardiac arrhythmias cause more than 300,000 sudden deaths each year in the USA alone. Long QT syndrome (LQT) is a cardiac disorder that causes sudden death from ventricular tachyarrhythmias, specifically torsade de pointes. Four LQT genes have been identified: KVLQT1 (LQT1) on chromosome 11p15.5, HERG (LQT2) on chromo...

journal_title：Annals of medicine

authors： Wang Q,Chen Q,Towbin JA

更新日期：1998-02-01 00:00:00

abstract：:Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na...

journal_title：Annals of medicine

authors： Ando K,Fujita T

更新日期：2012-06-01 00:00:00

abstract：:Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...

journal_title：Annals of medicine

authors： Ribacka C,Pesonen S,Hemminki A

更新日期：2008-01-01 00:00:00

abstract：:Atrial fibrillation is a common cardiac arrhythmia with rapid and irregular atrial activity. Instead of uniformly contracting as one chamber, the atrial compartment fibrillates. Several studies have demonstrated that this arrhythmia contributes substantially to cardiac morbidity and mortality. The purpose of this revi...

journal_title：Annals of medicine

authors： Miyazaki S,Shah AJ,Scherr D,Haïssaguerre M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...

journal_title：Annals of medicine

authors： Janatuinen T,Friberg J,Viljanen MK,Raitakari OT,Nuutila P,Vainionpää R,Oksi J,Peltonen R,Engblom E,Laine H,Knuuti J

更新日期：2002-01-01 00:00:00

abstract：:In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...

journal_title：Annals of medicine

authors： Kornitzer MD,Dramaix MM

更新日期：1989-06-01 00:00:00

abstract：:In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...

journal_title：Annals of medicine

authors： Wilhelmi de Toledo F,Grundler F,Sirtori CR,Ruscica M

更新日期：2020-08-01 00:00:00

abstract：:In three patients with attacks of acute intermittent porphyria we found markedly impaired functions of the left ventricle accompanied by ECG changes that returned to normal after administration of heme arginate or cytochrome C administration. In nine patients with other types of porphyria, and in one patient with acut...

journal_title：Annals of medicine

authors： Kordac V,Kozáková M,Martásek P

更新日期：1989-08-01 00:00:00

abstract：:The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecul...

journal_title：Annals of medicine

authors： Curtis AM,Fitzgerald GA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and wheth...

journal_title：Annals of medicine

authors： Liuba P,Aburawi EH,Pesonen E,Andersson S,Truedsson L,Ylä-Herttuala S,Holmberg L

更新日期：2007-01-01 00:00:00

abstract：:Regular presence and persistence of specific serum antibodies in Helicobacter pylori infection gives an excellent tool for diagnostic work. Eradication of the infection leads to gradual disappearance of the gastritis and decrease of specific serum antibodies. The fall of IgG and IgA antibody titres can be followed wit...

journal_title：Annals of medicine

authors： Kosunen TU

更新日期：1995-10-01 00:00:00