The future of psychiatric genetics.


:Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing complex inheritance. In this article, we consider the difficulties that complex diseases pose to genetic research, discuss progress and make suggestions regarding future directions.


Ann Med


Annals of medicine


van den Bree MB,Owen MJ




Has Abstract


2003-01-01 00:00:00












  • Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.

    abstract:BACKGROUND:Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS:This is a retrospective mu...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Carrasco-Sánchez FJ,López-Carmona MD,Martínez-Marcos FJ,Pérez-Belmonte LM,Hidalgo-Jiménez A,Buonaiuto V,Suárez Fernández C,Freire Castro SJ,Luordo D,Pesqueira Fontan PM,Blázquez Encinar JC,Magallanes Gamboa JO,de la Peña Fernánde

    更新日期:2021-12-01 00:00:00

  • Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS).

    abstract:INTRODUCTION:Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS:A total of 2003 individuals from the Helsinki Birth C...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Eriksson JG,Sandboge S,Salonen M,Kajantie E,Osmond C

    更新日期:2015-03-01 00:00:00

  • The Caveolin genes: from cell biology to medicine.

    abstract::Caveolae are vesicular organelles (50-100-nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Williams TM,Lisanti MP

    更新日期:2004-01-01 00:00:00

  • Birthplace predicts risk for prehospital sudden cardiac death in middle-aged men who migrated to metropolitan area: The Helsinki Sudden Death Study.

    abstract:BACKGROUND:Eastern-born male Finns, irrespective of their place of residence, have high mortality from coronary heart disease (CHD), and half of such deaths are sudden. AIM:To study whether eastern birthplace alone or combined with life-style factors predicts risk for prehospital sudden cardiac death (SCD) in the new ...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Tyynela P,Goebeler S,Ilveskoski E,Mikkelsson J,Perola M,Loytonen M,Karhunen PJ

    更新日期:2009-01-01 00:00:00

  • Coenzyme Q10, alpha-tocopherol and free cholesterol in HDL and LDL fractions.

    abstract::Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Johansen K,Theorell H,Karlsson J,Diamant B,Folkers K

    更新日期:1991-12-01 00:00:00

  • Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.

    abstract::Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closel...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Johansson B,Mertens F,Mitelman F

    更新日期:2004-01-01 00:00:00

  • ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study.

    abstract:BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

    更新日期:2009-01-01 00:00:00

  • Depression is associated with the metabolic syndrome among patients with type 1 diabetes.

    abstract:BACKGROUND:Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated. METHODS:A total ...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Ahola AJ,Thorn LM,Saraheimo M,Forsblom C,Groop PH,Finndiane Study Group.

    更新日期:2010-10-01 00:00:00

  • Autologous hematopoietic cell transplantation: an update for clinicians.

    abstract::High-dose chemotherapy followed by transplantation of autologous hematopoietic progenitor cells has a proven track record of safety and efficacy in hematological malignancies and select solid tumors. The near-universal use of peripheral blood stem cells as source for autografts, routine growth factor support, and anti...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Hamadani M

    更新日期:2014-12-01 00:00:00

  • Sequence analysis of the genes encoding for H+/K+-ATPase in autoimmune gastritis.

    abstract:BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

    更新日期:2006-01-01 00:00:00

  • Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination.

    abstract:BACKGROUND:Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and wheth...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Liuba P,Aburawi EH,Pesonen E,Andersson S,Truedsson L,Ylä-Herttuala S,Holmberg L

    更新日期:2007-01-01 00:00:00

  • Mucosal immunity and viral infections.

    abstract::The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Freihorst J,Ogra PL

    更新日期:2001-04-01 00:00:00

  • Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.

    abstract::Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis. The 4-hydroxyproline residues generated by the endoplasmic reticulum (ER) luminal collagen P4Hs (C-P4Hs) are essential for the stability of the collagen triple helix. Vertebrate C-P4Hs are alpha2beta...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Myllyharju J

    更新日期:2008-01-01 00:00:00

  • Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study.

    abstract::Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,多中心研究


    authors: Pérez-Belmonte LM,Osuna-Sánchez J,Millán-Gómez M,López-Carmona MD,Gómez-Doblas JJ,Cobos-Palacios L,Sanz-Cánovas J,Barbancho MA,Lara JP,Jiménez-Navarro M,Bernal-López MR,Gómez-Huelgas R

    更新日期:2019-01-01 00:00:00

  • Sleep and cardiac rhythm in healthy men.

    abstract::Cardiac rhythm during sleep was analysed in 168 healthy men aged 19 to 30 (mean 21.8) years using continuous nocturnal ECG recordings. Thirty five of the subjects were endurance athletes; 99 were recorded at home and 69 at a garrison during military service. The number of short term (less than one min) accelerations o...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Viitasalo M,Halonen L,Partinen M,Iivanainen M,Kala R,Eisalo A

    更新日期:1991-04-01 00:00:00

  • Triggers of IgE class switching and allergy development.

    abstract::The prevalence of immunoglobulin E (IgE)-mediated allergic diseases has been increasing for the last four decades. In this review determinants for an increased IgE synthesis are discussed on both an epidemiological and on an immunological level with special emphasis on the differentiation of the B cell to an IgE-produ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Poulsen LK,Hummelshoj L

    更新日期:2007-01-01 00:00:00

  • Factors influencing children's food choice.

    abstract::Although food habits arc not stable and unchanging during a person's lifetime, a base for healthy food habits can be created in early childhood. Children's food habits can be assumed to be influenced by their parents' food habits and choices. The aim of this article is to review factors influencing food choice in chil...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Hursti UK

    更新日期:1999-01-01 00:00:00

  • Risk factors for rheumatoid arthritis.

    abstract::Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Aho K,Heliövaara M

    更新日期:2004-01-01 00:00:00

  • Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality.

    abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Rüegg C,Zaric J,Stupp R

    更新日期:2003-01-01 00:00:00

  • Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births.

    abstract::INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Donnez J,Silber S,Andersen CY,Demeestere I,Piver P,Meirow D,Pellicer A,Dolmans MM

    更新日期:2011-01-01 00:00:00

  • Dietary fats, antioxidants and blood pressure.

    abstract::Although obesity and alcohol intake as well as dietary sodium, potassium and magnesium are the major non-genetic determinants of blood pressure levels, interest has recently been stimulated in the function of fatty acids and antioxidants in the aetiology of hypertension. In the Kuopio Ischaemic Heart Disease Risk Fact...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Salonen JT

    更新日期:1991-08-01 00:00:00

  • The role of bronchoalveolar lavage in the microbiological diagnosis of pneumonia in patients with haematological malignancies.

    abstract::In the aetiological diagnosis of pulmonary infections in patients affected by haematological malignancies we evaluated the utility of bronchoalveolar lavage (BAL). One hundred and twenty-seven BAL were performed in 119 patients. In our series, we identified the agent of pneumonia in 53.5% of episodes with the best res...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Pagano L,Pagliari G,Basso A,Marra R,Sica S,Frigieri L,Morace G,Ardito F,Leone G

    更新日期:1997-12-01 00:00:00

  • Cardiovascular Risk in Young Finns Study: general outline and recent developments.

    abstract::The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Akerblom HK,Viikari J,Raitakari OT,Uhari M

    更新日期:1999-04-01 00:00:00

  • Serotonin in early onset, male alcoholics with violent behaviour.

    abstract::Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Virkkunen M,Linnoila M

    更新日期:1990-01-01 00:00:00

  • Detection of Helicobacter pylori infection: when to perform which test?

    abstract::This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Braden B,Caspary WF

    更新日期:2001-03-01 00:00:00

  • Atherosclerosis and innate immune signaling.

    abstract::Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Laberge MA,Moore KJ,Freeman MW

    更新日期:2005-01-01 00:00:00

  • Insight into the genetic epidemiology of coronary heart disease.

    abstract::The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribut...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Cambien F

    更新日期:1996-10-01 00:00:00

  • Euthanasia and physician-assisted suicide.

    abstract::In the Netherlands there are about 9700 explicit requests for euthanasia or physician-assisted suicide (EAS) each year, of which approximately 3600 are granted. Other countries have criticized the Dutch policy concerning EAS. It has been suggested that palliative care in the Netherlands is not adequate and that euthan...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Swarte NB,Heintz AP

    更新日期:1999-12-01 00:00:00

  • Distribution of interleukin-1 receptor antagonist genotypes in sudden unexpected death in infancy (SUDI); unexplained SUDI have a higher frequency of allele 2.

    abstract:AIMS:This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile site...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Highet AR,Berry AM,Goldwater PN

    更新日期:2010-01-01 00:00:00

  • Angiotensin receptor antagonists in patients with nephropathy due to type 2 diabetes.

    abstract::In the past few years diabetes has become the leading cause of end-stage renal disease in all Western countries. A correlation between blood pressure and rate of progression in diabetic nephropathy was noted very early, and increased local activity of the renin angiotensin system was identified as a major pathophysiol...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Eberhard R,Dikow R

    更新日期:2002-01-01 00:00:00