Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment.

abstract：:Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting w...

journal_title：Annals of medicine

authors： Rueda-Camino JA,Losada-Vila B,De Ancos-Aracil CL,Rodríguez-Lajusticia L,Tardío JC,Zapatero-Gaviria A

更新日期：2016-01-01 00:00:00

abstract：:Pancreatic beta-cell dysfunction and insulin resistance are two interrelated defects in the pathophysiology of type 2 diabetes. Defects in peripheral insulin action precede the development of glucose intolerance, as the pancreas compensates for insulin resistance by increasing insulin production and secretion. This ma...

journal_title：Annals of medicine

authors： Sesti G

更新日期：2002-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of idiopathic interstitial pneumonia. The disease, which occurs primarily in middle-aged and older adults, is thought to arise following an aberrant reparative response to alveolar epithelial cell injury characterized by secretion of excessive amou...

journal_title：Annals of medicine

authors： Spagnolo P,Sverzellati N,Rossi G,Cavazza A,Tzouvelekis A,Crestani B,Vancheri C

更新日期：2015-02-01 00:00:00

abstract：:The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...

journal_title：Annals of medicine

authors： Gutzwiller F

更新日期：1994-02-01 00:00:00

abstract：:The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribut...

journal_title：Annals of medicine

authors： Cambien F

更新日期：1996-10-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment stra...

journal_title：Annals of medicine

authors： Gaede P,Pedersen O

更新日期：2004-01-01 00:00:00

abstract：:Large granular lymphocytic (LGL) leukemia is an incurable chronic disease, characterized by clonal expansion of cytotoxic T- or NK-cells in blood and bone marrow. Cytopenias (anemia, neutropenia) and autoimmune disorders such as rheumatoid arthritis are the most common clinical manifestations of LGL leukemia. Recently...

journal_title：Annals of medicine

authors： Rajala HL,Porkka K,Maciejewski JP,Loughran TP Jr,Mustjoki S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...

journal_title：Annals of medicine

authors： Janatuinen T,Friberg J,Viljanen MK,Raitakari OT,Nuutila P,Vainionpää R,Oksi J,Peltonen R,Engblom E,Laine H,Knuuti J

更新日期：2002-01-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...

journal_title：Annals of medicine

authors： Rüegg C,Zaric J,Stupp R

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...

journal_title：Annals of medicine

authors： Baldassarre D,De Jong A,Amato M,Werba JP,Castelnuovo S,Frigerio B,Veglia F,Tremoli E,Sirtori CR

更新日期：2008-01-01 00:00:00

abstract：:Potatoes (Solanum tuberosum) are an important food crop worldwide and contribute key nutrients to the diet, including vitamin C, potassium, and dietary fiber. Potatoes and potato components have been shown to have favorable impacts on several measures of cardiometabolic health in animals and humans, including lowering...

journal_title：Annals of medicine

authors： McGill CR,Kurilich AC,Davignon J

更新日期：2013-11-01 00:00:00

abstract：:Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...

journal_title：Annals of medicine

authors： Rivera R

更新日期：1993-02-01 00:00:00

abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...

journal_title：Annals of medicine

authors： Taskinen MR

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and wheth...

journal_title：Annals of medicine

authors： Liuba P,Aburawi EH,Pesonen E,Andersson S,Truedsson L,Ylä-Herttuala S,Holmberg L

更新日期：2007-01-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：:The Benchmarking Controlled Trial (BCT) is a novel concept which covers all observational studies aiming to assess effectiveness. BCTs provide evidence of the comparative effectiveness between health service providers, and of effectiveness due to particular features of the health and social care systems. BCTs compleme...

journal_title：Annals of medicine

authors： Malmivaara A

更新日期：2015-06-01 00:00:00

abstract：:Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...

journal_title：Annals of medicine

authors： Ribacka C,Pesonen S,Hemminki A

更新日期：2008-01-01 00:00:00

abstract：AIMS:This investigation was designed to explore the role of IL-1RN genotype in unexplained infant deaths (including sudden infant death syndrome (SIDS)), non-infectious infant deaths, and infectious infant deaths, and to investigate whether IL-1RN genotype is related to the finding of organisms in normally sterile site...

journal_title：Annals of medicine

authors： Highet AR,Berry AM,Goldwater PN

更新日期：2010-01-01 00:00:00

abstract：:Exposures of human populations to pesticides and industrial pollutants, and to synthetic chemicals present in foods, beverages, and plastics, have raised concern that these substances can interfere with endogenous sex hormone function. Interference with sex hormone action can, in turn, result in a variety of developme...

journal_title：Annals of medicine

authors： Akingbemi BT,Hardy MP

更新日期：2001-09-01 00:00:00

abstract：:Steroids diffuse through polysiloxone at a constant rate, and steroids placed in the vagina rapidly pass through the vaginal epithelium into the circulation. Combining these principles led to the development of contraceptive vaginal rings (CVR) consisting of various progestins, with and without oestrogen, placed in fl...

journal_title：Annals of medicine

authors： Mishell DR Jr

更新日期：1993-04-01 00:00:00

abstract：:In a national Belgian nutritional study (the B.I.R.N.H. Study), the authors review how far the Belgian population is from the recommended nutritional goals and ideal serum cholesterol. They also make comparisons between genders and look at differences according to the linguistic background (French- or Dutch-speaking s...

journal_title：Annals of medicine

authors： Kornitzer MD,Dramaix MM

更新日期：1989-06-01 00:00:00

abstract：:Due to its varied and variable phenotypes, Andersen-Tawil syndrome (ATS) holds a unique place in the field of channelopathies. Patients with ATS typically present with the triad of periodic paralysis, cardiac arrhythmias, and developmental dysmorphisms. Although penetrance of ATS is high, disease expression and severi...

journal_title：Annals of medicine

authors： Donaldson MR,Yoon G,Fu YH,Ptacek LJ

更新日期：2004-01-01 00:00:00

abstract：:The term fibromyalgia describes a complex syndrome characterized by pain amplification, musculoskeletal discomfort, and systemic symptoms. Although its existence has been controversial, nearly all rheumatologists now accept fibromyalgia as a distinct diagnostic entity. In fact, in the United States it is the third or ...

journal_title：Annals of medicine

authors： Wallace DJ

更新日期：1997-02-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) represents the most common form of genetic predisposition to colon cancer. Even in kindreds with several affected members it is, however, difficult to rule out chance clustering and other nonhereditary factors since colon cancer is so common in the general population. ...

journal_title：Annals of medicine

authors： Peltomäki PT

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

journal_title：Annals of medicine

authors： Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

更新日期：2009-01-01 00:00:00

abstract：:In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...

journal_title：Annals of medicine

authors： Wilhelmi de Toledo F,Grundler F,Sirtori CR,Ruscica M

更新日期：2020-08-01 00:00:00

abstract：:With the last two decades, the importance of genetic factors in the aetiology of major mental illness has been firmly re-established and psychiatric research has now firmly embraced the era of molecular genetics. Despite a number of false starts in the study of schizophrenia and affective disorder, there have been suc...

journal_title：Annals of medicine

authors： O'Donovan MC,Owen MJ

更新日期：1992-06-01 00:00:00

abstract：:Although food habits arc not stable and unchanging during a person's lifetime, a base for healthy food habits can be created in early childhood. Children's food habits can be assumed to be influenced by their parents' food habits and choices. The aim of this article is to review factors influencing food choice in chil...

journal_title：Annals of medicine

authors： Hursti UK

更新日期：1999-01-01 00:00:00